A5002767630- NMR spectroscopy and applications
- Analytical Chemistry and Chromatography
- Advanced MRI Techniques and Applications
- Polymer Synthesis and Characterization
- Advanced Neuroimaging Techniques and Applications
- Fluorine in Organic Chemistry
- Metabolomics and Mass Spectrometry Studies
- Computational Drug Discovery Methods
- Drug Solubulity and Delivery Systems
- Extraction and Separation Processes
- Analytical Methods in Pharmaceuticals
- Eicosanoids and Hypertension Pharmacology
- Renal function and acid-base balance
- Synthesis and Reactions of Organic Compounds
- Synthesis and Characterization of Pyrroles
- Chemical synthesis and pharmacological studies
- Dendrimers and Hyperbranched Polymers
- Molecular Sensors and Ion Detection
- Thermodynamic properties of mixtures
- Chromatography in Natural Products
- Molecular spectroscopy and chirality
- Chemical Thermodynamics and Molecular Structure
- Synthesis and Catalytic Reactions
- Diffusion Coefficients in Liquids
- Synthesis and Biological Evaluation
Ministry of Health of the Russian Federation
2013-2021
Federal State Budgetary Institution "Center for Expertise and Quality Control of Medical Care"
2015-2018
Military Academy of Radiation, Chemical and Biological Protection
2005-2006
INTRODUCTION . Polymyxin B is a natural multicomponent antibiotic used in its sulfate form for the treatment of infections caused by multidrug-resistant Gram-negative bacteria. Pharmacopoeial standards polymyxin medicinal products include limits sum polymyxins B1, B2, B3, and B1-I individual B3 B1-I. Since B1 B2 differ their nephrotoxicity, it important to establish content products. Establishing requires determining component composition various samples. However, high-performance liquid...
Near-infrared spectrometry (NIRS) is a new pharmacopoeial method. It widely used in the pharmaceutical industry for quality control of medicinal products at various production stages (control raw materials and finished products), detection substandard counterfeit drugs. The aim study was to assess feasibility using NIRS as an identification test active ingredients during pre-marketing products. Materials methods: 327 drugs samples represented solid semisolid dosage forms were tested by...
Scientific relevance. Hypromellose phthalate is used in enteric coatings for oral medicinal products. The proportion of groups the polymer standardised because it has a significant effect on solubility. Whereas, molecular mass hypromellose not controlled, and its impact solubility media with different pH values understudied. Aim . study aimed to employ NMR spectroscopy investigate may have dissolution kinetics at value declared by manufacturer. Materials methods. analysed isolated from...
The work is a continuation of the research on use NMR spectroscopy in quality control natural peptide hormone-based active substances and their synthetic analogues. aim paper was to develop identification test methods for triptorelin acetate goserelin using that does not require reference standards ‒ with newly developed pharmacopoeial analysis. Materials methods: procedure two-dimensional ( 1 H- H gCOSY, 13 C gHSQC, gHMBC). Results: thestudy made it possible assign signals specific...
The number, shape and position of NMR spectral lines depend on dynamic processes, this creates certain difficulties in identification pharmaceutical substances by spectroscopy. aim the paper was to study instances manifestation intramolecular processes that affect organic compounds NMR, illustrate potential methods used for their reduction, as well associated problems. Materials : 1 H 13 C spectra following substances: «buserelin acetate», «valsartan», «goserelin «iopromide», «clopidogrel...
Gentamicin sulfate is a broad-spectrum bactericidal aminoglycoside antibiotic produced by Micromonospora purpurea and used in clinical practice as an active substance containing mixture of gentamicins C 1 2 . content standardised parameter controlled part pharmaceutical product review. Currently, the quality control gentamicin involves use high-performance liquid chromatography (HPLC) for indirect identification component composition comparison with reference standard its quantification...
Scientific relevance. Hypromellose phthalate is a component of enteric coatings used to modify active substance release from oral medicinal products in the small intestine. The rate directly depends on non-stoichiometric composition polymer, first all, proportion groups macromolecule. It therefore necessary develop reliable analytical procedures for determining structure hypromellose evaluate dissolution containing polymer. Aim. study aimed an procedure quantifying samples using NMR...
The ongoing development of the Pharmacopoeia Eurasian Economic Union and current trend for harmonisation Russian with world leading pharmacopoeias suggest necessity studying how different use nuclear magnetic resonance (NMR) quality control medicinal products. aim study was to compare extent medicine characteristics assessed by NMR in foreign pharmacopoeias. review summarises experience various national using method medicines certification pharmacopoeial reference materials. comparative...