Intra-articular injection of adipose mesenchymal stem cells (ADSCs) is a potential alternative to the treatment osteoarthritis (OA) and has aroused great interest clinical researchers. However, hostile microenvironment in joint cavity, characterized by reactive oxygen species (ROS) accumulation excessive inflammation, disturbs bioactivity transplanted cells. The (-)-epigallocatechin-3-O-gallate (EGCG), green tea catechin, attracted researchers’ attention owing its powerful ROS-scavenging...

Brain anatomical age is an effective feature to assess the status of brain, such as atypical development and aging. Although some deep learning models have been developed for estimating infant brain age, performance these was unsatisfactory because few them considered developmental characteristics anatomy during perinatal period-the most rapid complex stage across lifespan. The present study proposed attention-based hemispheric relation inference network (HRINet) that takes advantage nature...

This study aims to investigate the implementation strategy, unintended consequences, and underlying barriers mandatory antimicrobial stewardship (AMS) programs in China. Face-to-face, in-depth qualitative interviews were conducted 16 public hospitals eastern, central, western Hospitals purposely selected with full consideration represent both economically developing developed areas secondary tertiary care hospitals. A total of 111 respondents interviewed, including 38 doctors, 28 clinical...

An atmospheric pressure plasma jet is generated by dual sinusoidal wave (50 kHz and 2 MHz). The dual-frequency exhibits the advantages of both low frequency radio plasmas, namely, long plume high electron density. ignition voltage can be reduced significantly using excitation compared to conventional without aid source. A larger operating range α mode discharge obtained which important obtain homogeneous low-temperature plasma. controllable gas temperature could also excitation.

Abstract Background Antimicrobial stewardship (AMS) programs have been widely adopted and proven to be effective optimize antibiotic use. After a decade of efforts in mandatory AMS implementation, inappropriate prescribing antimicrobial resistance are still disproportionately prevalent China. We aim investigated the underlying barriers from multidisciplinary health system perspective Chinese context. Example quotes interview transcripts that illustrate validate themes Methods Face-to-face,...

SUMMARY OBJECTIVES HOXB2 is a new prognostic indicator for lung cancer. But it unclear whether holds an effect in glioblastoma (GBM) progression. The purpose of this article was to probe the influences on GBM pathogenesis. METHODS expression level and power patients were analyzed. Then mRNA protein levels cell lines tested by qRT-PCR western blotting. Cell proliferation, invasion, migration determined CCK8 transwell assay, severally. PI3K/AKT-pathway associated proteins analyzed RESULTS...

Abstract Background Little previous research has been conducted outside of major cities in China to examine how physicians currently perceive palliative care, and identify specific goals for training as care access expands. This study explored physicians’ perceptions integration advanced cancer patients Changsha, China. Methods We semi-structured qualitative interviews with (n = 24) specializing hematology or oncology at a tertiary hospital. Results Most viewed equivalent end-of-life while...

Glioblastoma (GBM) is one of the most common and malignant types primary cancer in central nervous system; however, clinical outcomes patients with GBM remain poor. Circular RNAs (circRNAs) have been revealed to serve important roles diverse biological processes, such as regulating cell proliferation, epithelial‑mesenchymal transition tumor development. However, underlying function circRNA filamin A (circFLNA) its potential role be determined. The present study aimed identify differentially...

Attention-deficit/hyperactivity disorder (ADHD) is one of the most common disorders in child and adolescent psychiatry, with a prevalence more than 5%. Despite extensive research on ADHD last 10 to 20 years, effective treat-ments are still lacking. Instead, concept seems have become broader heterogeneous. Therefore, diagnosis treatment remains challenging for clinicians.To investigate effects multimodal integrated intervention children ADHD.Between March 2019 September 2020, total 100 who...

Streptococcus suis serotype 2 (SS2) is a serious zoonotic pathogen; it can lead to symptoms of streptococcal toxic shock syndrome (STSS) in humans and sepsis pigs, poses great threat public health. The SS2 MetQ gene deletion strain has attenuated antiphagocytosis, although the mechanism antiphagocytosis pathogenesis remained unclear. In this study, stable isotope labeling by amino acids cell culture (SILAC) based liquid chromatography-mass spectrometry (LC-MS) subsequent bioinformatics...

Herein, a new heterogeneous CoSe2-x@N-C material with abundant selenium vacancies is synthesized via an in-situ carbonization-selenization process from cobaltic metal organic framework (Co-MOF). The obtained has unique electronic structure and rich active sites, which can activate peroxymonosulfate (PMS) to degrade carbamazepine (CBZ) superior catalytic performance stability. quenching experiments EPR test show that SO4•− the dominant reactive oxidation species (ROSs) for CBZ degradation....

Tuberculosis (TB) among women and infants during the perinatal period is not rare, particularly in countries with a high TB burden. And risk would increase significantly following vitro fertilization-embryo transfer (IVFET). Worse still, this stage apt to develop into severe forms neonates, such as disseminated or tuberculous meningitis (TBM). On other hand, adverse effects (SAEs) of anti-tuberculosis (ATB) agents neonates were common but difficult diagnose early manage well.

Objective To study the significance of application intraoperative neurophysiological monitoring in endovascular treatment for intracranial aneuryms with vasospasm or stenosis.Methods Intraoperative was performed during 28 patients stenosis.The in-time adjustments,such as capacity enlargement,blood pressure increasing,spasmolysis even stopping procedure,were according to variation so make procedure successfully and reduce post-operative complications.Results There were 10 stenosis 18...

Abstract Background: The use of electronic informed consent (eIC) in clinical research is trending China. Nevertheless, even as Chinese medical researchers implement eIC, little known about their knowledge the technology or perspectives on its use. Ours first study to assess and attitudes toward eIC This aims better advance application development Methods: A cross-sectional survey was conducted. Using stratified random sampling, we recruited from six provincial hospitals two municipal Hunan...

Abstract AIM To explore the changes in microstructure and blood supply of outer retina eyes at high risk progression to age–related macular degeneration (AMD). METHODS Forty-seven patients unilateral neovascular AMD (nAMD) were enrolled, twenty-two healthy contralateral considered (Group1), other twenty-five dry (Group2). Fifty subjects (50 eyes) enrolled as control. Swept-source optical coherence tomography equipped with angiovue was used obtain three-dimensional retinal thickness maps,...