A5006587170- HIV/AIDS drug development and treatment
- Pharmacological Effects and Toxicity Studies
- HIV Research and Treatment
- Antibiotics Pharmacokinetics and Efficacy
- Pharmaceutical studies and practices
- HIV/AIDS Research and Interventions
- HIV-related health complications and treatments
- Drug Transport and Resistance Mechanisms
- Diabetes Management and Research
- Pharmacovigilance and Adverse Drug Reactions
- Pneumocystis jirovecii pneumonia detection and treatment
- Diabetes Treatment and Management
- Thyroid Cancer Diagnosis and Treatment
- Epilepsy research and treatment
- Drug-Induced Adverse Reactions
- Neuroblastoma Research and Treatments
- Cardiovascular Function and Risk Factors
- Bariatric Surgery and Outcomes
- Diet and metabolism studies
- Antimicrobial Resistance in Staphylococcus
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Drug-Induced Hepatotoxicity and Protection
- Safe Handling of Antineoplastic Drugs
- Pneumonia and Respiratory Infections
- Cardiac pacing and defibrillation studies
Institut d'Investigació Biomédica de Bellvitge
2018-2025
Bellvitge University Hospital
2018-2025
Universitat de Barcelona
2019-2025
Centro de Investigación Biomédica en Red
2025
Hospital de Sant Pau
2025
Centro de Investigación en Red en Enfermedades Cardiovasculares
2025
Universitat Autònoma de Barcelona
2025
Hospital Universitario Son Espases
2020-2024
Hospital Clínico Universitario Virgen de la Victoria
2022
Hospital Universitario Severo Ochoa
2004-2022
ObjectivesThe objectives of this study were to characterize the population pharmacokinetics vancomycin in trauma patients and propose dosing schemes optimize therapy.
Objectives: To determine the pharmacokinetic parameters of gentamicin in a population 200 premature newborns and to investigate influence several clinical physiopathological covariates on pharmacokinetics drug. validate analysis performed another 50 newborns.
The choice of antiretroviral drugs has evolved over the last decade. Recognition trends and determinants changes may help to make predictions on prescription patterns.Longitudinal analyses were performed every 6 months from 1996 2006, all HIV-infected individuals who attended at one HIV/AIDS referral centre located in Madrid, Spain.A total 2602 different attending during study period examined 23 consecutive time-points. number proportion patients under therapy significantly increased...
Building on results from the AELIX-002 trial with HIVACAT T-cell immunogen (HTI)-based vaccines, AELIX-003 (NCT04364035) tested safety of combination ChAdOx1.HTI (C) and MVA.HTI (M), TLR7 agonist vesatolimod (VES), in a double-blind, placebo-controlled, randomized clinical 50 virally suppressed early-treated men HIV-1 infection. Secondary objectives included immunogenicity effects viral rebound kinetics during 24-week antiretroviral treatment interruption (ATI). The most common...
To assess the association between biomarkers of inflammation, coagulation and immune activation incidence non-AIDS-defining events in a contemporary, antiretroviral therapy (ART)-experienced virologically suppressed cohort people living with HIV (PLWH). Prospective, observational study. PLWH aged 30-70 years, undetectable viral load no history cardiovascular disease, randomly selected from outpatients were included. At baseline, plasma (high-sensitivity C-reactive protein [hs-CRP], sCD163,...
Pathophysiological changes involved in drug disposition critically ill patients should be considered order to optimize the dosing of vancomycin administered by continuous infusion, and certain strategies must applied reach therapeutic targets on first day treatment. The aim this study was develop a population pharmacokinetic model determine clinical covariates, including mechanical ventilation, that influence wide variability antimicrobial. Plasma concentrations from 54 were analyzed...
The aim of this study was to characterize and validate the population pharmacokinetics gentamicin in infants determine influences clinically relevant covariates explain inter- intraindividual variabilities associated with drug. Infants receiving intravenous routine therapeutic drug monitoring were consecutively enrolled study. Plasma concentration time data retrospectively collected from 208 (1 24 months old) Hospital Universitario Severo Ochoa (Spain), whom 44% males (mean age [± standard...
La determinación de las concentraciones plasmáticas antiepilépticos para el tratamiento y profilaxis la epilepsia es una estrategias que permiten mejorar los resultados clínicos, reduciendo efectos adversos aumentando efectividad. El objetivo este artículo revisar aspectos básicos en mediante un documento consenso realizado avalado por grupo trabajo farmacocinética farmacogenética Sociedad Española Farmacia Hospitalaria (PK.gen). Monitoring plasma levels of antiepileptic drugs for the...
Background: Obesity is associated with increased morbimortality cardiovascular. Individual metabolic syndrome (MS) are a high risk of developing cardiovascular disease (CVD). The aim this study was to determine the prevalence MS in morbidly obese patients enrolling bariatric surgery program and evaluate impact weigh loss induced by gastric bypass on predicted 10-year risk. Material methods: We studied 46 who underwent laparoscopic were followed for 2 years. defined following IDF 2005...
The aim of this study was to characterize the population pharmacokinetics amikacin in elderly patients by means nonlinear mixed effects modelling and propose initial dosing schemes optimize therapy based on PK/PD targets.A total 137 from 65 94 years receiving intravenous routine therapeutic drug monitoring at Hospital Universitario Severo Ochoa were included. Concentration-time data clinical information retrospectively collected; doses ranged 5.7 22.5 mg/kg/day each patient provided between...
We determined total and unbound concentrations of bictegravir (BIC) in cerebrospinal fluid (CSF) 15 asymptomatic, virologically suppressed patients. The median plasma CSF BIC were 1837.1 ng/mL (interquartile range [IQR], 1237.2-2586.7) 6.9 (IQR, 4.8-10.9), respectively. Median concentration was 2.48 1.6-3.7). Total above the half-maximal effective value all patients, subjects had human immunodeficiency virus viral suppression CSF. Bictegravir may contribute to inhibit replication this compartment.
The pharmacokinetics of bictegravir (BIC) and its association with the decay human immunodeficiency virus (HIV)-1 RNA in genital fluids rectum have not yet been addressed.
Objective To assess the effect of HIV infection and combined antiretroviral therapy (c-ART) on various proatherogenic biomarkers lipids to investigate their relationship with subclinical atherosclerosis in a cohort treatment-naive HIV-infected patients. Methods We performed prospective, comparative, multicenter study 2 groups patients (group A, CD4>500 cells/μL, not starting c-ART; group B, CD4<500 c-ART at baseline) healthy control group. Laboratory analyses carotid ultrasound were baseline...
This study assessed the penetration and efficacy of tenofovir alafenamide (TAF) in male genital tract (MGT) semen quality individuals infected with human immunodeficiency virus (HIV)-1 who were treated a TAF-containing regimen.
The purpose of the present study was to calculate cost-effectiveness inclusion bevacizumab (BVZ) + irinotecan (CPT-11) regimen in second-line treatment for primary glioblastoma multiforme. A retrospective cohort with a control group performed which course chemotherapy calculated based on survival time and incremental cost between two lines treatment. total 77 patients were included, 36 who formed BVZ/CPT-11 cohort. median non-BVZ 13.23 months [95% confidence interval (CI), 11.79-14.68],...