J. Patrick Mershon

ORCID: 0000-0003-1327-4134
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About
Contact & Profiles
Research Areas
  • Malaria Research and Control
  • Renal cell carcinoma treatment
  • Renal and related cancers
  • Mosquito-borne diseases and control
  • Pediatric Urology and Nephrology Studies
  • Bacteriophages and microbial interactions
  • Urologic and reproductive health conditions
  • Urinary Bladder and Prostate Research
  • Genital Health and Disease
  • Pelvic floor disorders treatments
  • Urinary Tract Infections Management
  • Urological Disorders and Treatments
  • Bacterial biofilms and quorum sensing
  • Surgical Simulation and Training
  • Kidney Stones and Urolithiasis Treatments
  • Coagulation, Bradykinin, Polyphosphates, and Angioedema
  • Maternal and fetal healthcare
  • Pancreatic and Hepatic Oncology Research
  • Artificial Intelligence in Healthcare and Education
  • Parasite Biology and Host Interactions
  • Urinary and Genital Oncology Studies
  • Bacterial Genetics and Biotechnology
  • Complement system in diseases
  • Clinical Nutrition and Gastroenterology
  • Simulation-Based Education in Healthcare

The Ohio State University Wexner Medical Center
2023-2024

The Ohio State University
2021-2024

University of Virginia
2019-2023

National Institute of Allergy and Infectious Diseases
2018-2021

National Institutes of Health
2018-2021

U.S. National Arboretum
2017

Agricultural Research Service
2017

Kenyon College
2012

Indiana University – Purdue University Indianapolis
1986

Indiana University School of Medicine
1986

ABSTRACT The ability of Escherichia coli and Bacillus subtilis to regulate their cytoplasmic pH is well studied in cell suspensions but poorly understood individual adherent cells biofilms. We observed the using ratiometric pHluorin. A standard curve equating fluorescence ratio with was obtained by perfusion at a range external 5.0 9.0, uncouplers that collapse transmembrane difference. Adherent were acid stressed switching medium from 7.5 5.5. E. fell value varied among (range 6.2 6.8),...

10.1128/aem.00354-12 article EN Applied and Environmental Microbiology 2012-03-17

Significance Artemisinin-based combination therapies (ACTs) are first-line antimalarial used worldwide. The artemisinin drug (ART) component clears the bulk of infection rapidly, but small numbers persistent parasites must be removed by partner drug. Longer parasite clearance t 1/2 values have been associated with a Kelch-propeller mutation (K13 C580Y), raising concerns increased ART resistance. We investigated effects C580Y using Plasmodium falciparum cross and monkey malaria model....

10.1073/pnas.1813386115 article EN Proceedings of the National Academy of Sciences 2018-11-19

Appropriately mixed, compatible solutions of glucose, amino acids and lipid have recently become available for clinical use. While a single hyperalimentation solution has several advantages over the conventional two‐bottle technique, its effect on infusion‐related septicemia is unknown. An in vitro, mock infusion system identical to that used our newborn intensive care unit was set up assess relative growth rates three microorganisms parenteral nutrition mixtures. Growth Staphylococcus...

10.1177/0148607186010005498 article EN Journal of Parenteral and Enteral Nutrition 1986-09-01

Unlike the case in Asia and Latin America, Plasmodium vivax infections are rare sub-Saharan Africa due to absence of Duffy blood group antigen (Duffy antigen), only known erythrocyte receptor for P. merozoite invasion ligand, binding protein 1 (DBP1). However, have been documented Duffy-negative individuals throughout Africa, suggesting that may use ligands other than DBP1 invade erythrocytes through receptors. To identify potential ligands, we compared parasite gene expression Saimiri Aotus...

10.1073/pnas.1818485116 article EN Proceedings of the National Academy of Sciences 2019-03-14

A filamentous bacteriophage, designated ϕRs551, was isolated and purified from the quarantine select agent phytopathogen Ralstonia solanacearum race 3 biovar 2 strain UW551 (phylotype IIB sequevar 1) grown under normal culture conditions. Electron microscopy suggested that ϕRs551 is a member of family Inoviridae, about 1200 nm long 7 wide. has genome 7929 nucleotides containing 14 open reading frames, first virion contains resolvase (ORF13) putative type-2 phage repressor (ORF14). Unlike...

10.1371/journal.pone.0185034 article EN public-domain PLoS ONE 2017-09-21

OpenAI's ChatGPT is a large language model-based artificial intelligence (AI) chatbot that can be used to answer unique, user-generated questions without direct training on specific content. Large models have significant potential in urologic education. We reviewed the primary data surrounding use of urology. also reported findings our study assessing performance renal cell carcinoma (RCC)

10.21037/tcr-23-2234 article EN Translational Cancer Research 2024-06-11

You have accessJournal of UrologyBladder & Urethra: Anatomy, Physiology Pharmacology (PD12)1 May 2024PD12-04 SGLT2 INHIBITORS ASSOCIATE WITH OVERACTIVE BLADDER SYMPTOMS J. Patrick Mershon, Taylor Weatherly, Erin Gill, Hafsa Asif, Dairon Denis-Diaz, Courtenay Moore, and Iryna Crescenze MershonJ. Mershon , WeatherlyTaylor Weatherly GillErin Gill AsifHafsa Asif Denis-DiazDairon Denis-Diaz MooreCourtenay Moore CrescenzeIryna View All Author...

10.1097/01.ju.0001008772.30001.48.04 article EN The Journal of Urology 2024-04-15

Abstract Background Plasmodium knowlesi is now the major cause of human malaria in Malaysia, complicating control efforts that must attend to elimination multiple species. Recent advances cultivation P. erythrocytic-stage parasites vitro, transformation with exogenous DNA, and infection mosquitoes gametocytes from culture have opened up studies this pathogen without need for resource-intensive costly non-human primate (NHP) models. For further understanding development methods parasite...

10.1186/s12936-021-03773-4 article EN cc-by Malaria Journal 2021-06-05

Introduction: Though urology attracts well-qualified applicants, students are not typically provided exposure to this smaller specialty until later in their medical education. While simulation-based training continues supplement education, there is a lack of programming teach specialty-specific procedural skills and those outside the specialty. We report half-day simulation didactic-based approach increase interested second-year students. Methods: A didactic- session was offered (N=57)....

10.5489/cuaj.8518 article EN Canadian Urological Association Journal 2023-11-20

You have accessJournal of UrologyCME1 Apr 2023MP47-16 MICROWAVE ABLATION VERSUS PARTIAL NEPHRECTOMY FOR SMALL RENAL MASSES Jessica Qiu, Emmett H. Kennady, Chris Ballantyne, Clinton Yeaman, John Morgan, Anthony Denovio, Matthew B. Clements, J. Patrick Mershon, Iman Richie, Tracey L Krupski, Noah S. Schenkman, and Jennifer M. Lobo QiuJessica Qiu More articles by this author , KennadyEmmett Kennady BallantyneChris Ballantyne YeamanClinton Yeaman MorganJohn Morgan DenovioAnthony Denovio...

10.1097/ju.0000000000003293.16 article EN The Journal of Urology 2023-03-23

Introduction: Percutaneous nephrolithotomy (PCNL) is the gold standard for treating large or complex renal stones. Renal drainage after procedure most commonly via nephrostomy tube indwelling ureteral stent, but optimal duration of stents PCNL unknown. This study describes post-operative events occurring with early stent removal on postoperative day one (POD1) in patients undergoing uncomplicated PCNL. Methods: We identified 336 from a single institution that underwent between 1/1/2020 and...

10.22374/jeleu.v6i2.159 article EN Journal of Endoluminal Endourology 2023-04-25

Despite a high prevalence of neurogenic bladder (NGB) in patients with spinal cord injury (SCI), clinicians are unable to predict long-term outcomes due variable phenotypes dysfunction. This study investigates if early events, infections, and characteristics during rehabilitation admission affect one year after SCI.This retrospective included SCI admitted tertiary center between 1 January 2016 2020. Data was collected on management, comorbidities, infections characteristics; level injury,...

10.1080/10790268.2023.2279271 article EN Journal of Spinal Cord Medicine 2023-12-13

Abstract Background Plasmodium knowlesi is now the major cause of human malaria in Malaysia, complicating control efforts that must attend to elimination multiple species. Recent advances cultivation P. erythrocytic-stage parasites vitro , transformation with exogenous DNA, and infection mosquitoes gametocytes from culture have opened up studies this pathogen without need for resource-intensive costly non-human primate (NHP) models. For further understanding development methods parasite...

10.1101/2021.03.30.437722 preprint EN cc-by-nc-nd bioRxiv (Cold Spring Harbor Laboratory) 2021-03-30
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