A5090414207- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Venous Thromboembolism Diagnosis and Management
- Crystallography and molecular interactions
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- Hemophilia Treatment and Research
- Cardiac Structural Anomalies and Repair
- Shoulder Injury and Treatment
- Aldose Reductase and Taurine
- Musculoskeletal synovial abnormalities and treatments
- Carbohydrate Chemistry and Synthesis
- Immune Cell Function and Interaction
- Microbial metabolism and enzyme function
- Blood transfusion and management
- Biochemical Acid Research Studies
- Orthopaedic implants and arthroplasty
- Platelet Disorders and Treatments
- Total Knee Arthroplasty Outcomes
- Analytical Chemistry and Chromatography
- Respiratory viral infections research
- Vaccine Coverage and Hesitancy
- Immunotherapy and Immune Responses
- Insect and Arachnid Ecology and Behavior
- Enzyme Structure and Function
MedStar Union Memorial Hospital
2024
MedStar Franklin Square Medical Center
2023
CancerCare
2021
Kyung Hee University Hospital at Gangdong
2013-2016
National Centre for Biological Sciences
1994-2013
Cold Spring Harbor Laboratory
2013
Kyung Hee University
2011-2012
Beckman Coulter Foundation
2004
Florida State University
1998-2000
Rutgers, The State University of New Jersey
1998
Pfizer-BioNTech, Moderna, and Johnson & Johnson's Janssen are the 3 COVID-19 vaccines authorized for emergency use in United States. This study aims to analyze compare adverse events following immunization associated with these based on Vaccine Adverse Effect Reporting System data.We utilized data from January 1, 2021 April 30, characterize effects postvaccination US population.A total of 141,208 individuals suffered at least one 239.97 million doses vaccination. The frequency side was...
Execution of total knee arthroplasty (TKA) in end-stage haemophilic arthropathy is challenging because soft tissue fibrosis, flexion contractures, poor quality the bone, and altered bony anatomy. Restoring lower limb alignment achieving range motion (ROM) difficult. Robots have been used TKA to reduce chances malalignment improve accuracy precision. However, there has no report literature on use robots for arthropathy. The aim this study was evaluate whether robot-assisted can be...
The shared surface topology of two chemically dissimilar but functionally equivalent molecular structures has been analyzed. A carbohydrate moiety (α-D-mannopyranoside) and a peptide molecule (DVFYPYPYASGS) bind to concanavalin at common binding site. cross-reactivity the polyclonal antibodies (pAbs) was used for understanding topological relationship between these independent ligands. anti-α-D-mannopyranoside pAbs recognized various ligands A, anti-DVFYPYPYASGS ligands, providing direct...
We studied complete dose–response curves for 53 odorants in the third instar larvae of Drosophila melanogaster. All odorants, except one, elicited an attraction response. Some also a decrease from their peak response at higher concentrations. This concentration-dependent olfactory could be due to either desensitization or repulsion, 2 possibilities that we cannot distinguish our current assay. observed high variations factors like slopes, thresholds, and peaks responses that, agreement with...
The three-dimensional structure of Corynebacterium 2,5-diketo- d -gluconic acid reductase A (2,5-DKGR A; EC 1.1.1.-), in complex with cofactor NADPH, has been solved by using x-ray crystallographic data to 2.1-Å resolution. This enzyme catalyzes stereospecific reduction -gluconate (2,5-DKG) 2-keto- l -gulonate. Thus the now for a prokaryotic example aldo–keto superfamily. details binding NADPH help explain why 2,5-DKGR exhibits lower affinity than related human aldose does. Furthermore,...
Postoperative venous thromboembolism is one of the most serious complications following total joint arthroplasty. Pharmacological and mechanical prophylaxis methods are used to reduce risk postoperative symptomatic deep vein thrombosis pulmonary embolism. Use pharmacological requires a fine balance between efficacy drug in preventing adverse effects associated with use these drugs. In regions low prevalence such as Korea, there might be question whether benefits using outweigh risks...
Abstract CD1 proteins are unique in their ability to present lipid Ags T cells. Human CD1b shares significant amino acid homology with mouse CD1d1, which contains an unusual putative Ag-binding groove formed by two large hydrophobic pockets, A′ and F′. We investigated the function of residues that line F′ pockets engineering 36 alanine-substitution mutants analyzing mycobacterial glycolipid Ags. Two presented were studied, a naturally occurring glucose monomycolate (GMM) isolated from...
2,5-Diketo-D-gluconic acid reductase (2,5-DKGR; E.C. 1.1.1.-) catalyzes the Nicotinamide adenine dinucleotide phosphate (NADPH)-dependent stereo-specific reduction of 2,5-diketo-D-gluconate (2,5-DKG) to 2-keto-L-gulonate (2-KLG), a precursor in industrial production vitamin C (L-ascorbate). Microorganisms that naturally ferment D-glucose 2,5-DKG can be genetically modified express gene for 2,5-DKGR, and thus directly produce from D-glucose. Two occurring variants DKGR (DKGR A B) have been...
Total knee arthroplasty (TKA) in end-stage haemophilic arthropathy is complex and challenging due to the altered bony anatomy, arthrofibrosis muscle contractures. Computer navigation especially advocated patients with deformity or anatomy improve alignment assist ligament balancing. The objective of this study was evaluate results computer-navigated TKA arthropathy. A consecutive series computer-assisted for between February 2007 December 2009 were evaluated. total 27 performed 25 patients....
Summary The purpose of this study was to evaluate the efficacy and safety postoperative wound drain salvage autotransfusion system in haemophilic patients undergoing elective total knee arthroplasty (TKA). No literature exists on reinfusing drained blood patient with haemophilia TKA. Eighty‐eight knees 66 received cemented TKA due end‐stage arthropathy (group I; 59 knees, group II; without 29 knees). In I, shed transfused within 6 h after surgery. amount drainage reinfused blood, rate...
A 75-year-old man with history of paroxysmal atrial fibrillation developed acute pulmonary oedema immediately after permanent pacemaker insertion for symptomatic bradycardia and was transferred to our institution. Echocardiography prior showed normal left ventricle (LV) function mild mitral regurgitation (MR). single-chamber had been inserted the ventricular lead positioned in right apex. He treated diuretics improvement. Investigations failed reveal a cause cardiac failure. Patient...
SCAD (Spontaneous Coronary Artery Dissection) is a rare disorder which rarely recurs. It increasingly diagnosed as cause for acute coronary syndrome (ACS) with limited insight into its pathophysiology and treatment. Lack of randomized trials consensus guidelines make this unique challenging disease to manage. We describe complex case recurrent idiopathic prior history NSTE-ACS (Non-ST elevation Acute Syndrome) discuss management based on current clinical practices.
s for the 19th Annual Scientific Meeting of International Society Biological Therapy Cancer, San Francisco, California, November 4-7, 2004: Immune Monitoring