A5073312106- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Pediatric health and respiratory diseases
- Lung Cancer Research Studies
- Neonatal Respiratory Health Research
- Lung Cancer Treatments and Mutations
- Asthma and respiratory diseases
- Gut microbiota and health
- Respiratory viral infections research
- Cancer Immunotherapy and Biomarkers
- Respiratory and Cough-Related Research
- Lung Cancer Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Gastric Cancer Management and Outcomes
- Bacteriophages and microbial interactions
- Vitamin D Research Studies
- RNA modifications and cancer
- Pancreatic and Hepatic Oncology Research
- Smoking Behavior and Cessation
- Diet and metabolism studies
- Education, Healthcare and Sociology Research
- Esophageal Cancer Research and Treatment
- Phagocytosis and Immune Regulation
- Fatty Acid Research and Health
- Cancer Genomics and Diagnostics
Haukeland University Hospital
2015-2025
University of Bergen
2013-2025
St Olav's University Hospital
2020
Kirkelig Pedagogisk Senter
2020
Vestre Viken Hospital Trust
2020
Introduction COPD patients may be at increased risk for vitamin D (25(OH)D) deficiency, but factors deficiency among have not been extensively reported. Methods Serum 25(OH)D levels were measured by liquid chromatography double mass spectrometry in subjects aged 40–76 years from Western Norway, including 433 (GOLD stage II-IV) and 325 controls. Levels <20 ng/mL defined deficiency. Season, sex, age, body index (BMI), smoking, GOLD stage, exacerbation frequency, arterial oxygen tension (PaO2),...
The aim of the present study was to analyse interaction between asthma and smoking in risk adult airway obstruction, accounting for atopy. In European Community Respiratory Health Survey, 15 668 persons aged 20-56 years underwent spirometry 1991-1993 9 later (n=8916). Risk obstruction lung function decline associated with early-onset (<10 age) late-onset (>10 were analysed generalised estimating equation models random-effect linear models, adjusting covariates. Interaction expressed as...
COPD exacerbations accelerate disease progression.To examine if characteristics and systemic inflammatory markers predict the risk for acute exacerbation (AECOPD) frequency duration.403 patients, GOLD stage II-IV, aged 44-76 years were included in Bergen Cohort Study 2006/07, followed 3 years. Examined baseline predictors sex, age, body composition, smoking, AECOPD last year, stage, Charlson comorbidity score (CCS), hypoxemia (PaO2<8 kPa), cough, use of inhaled steroids, leucocytes,...
Antimicrobial peptides (AMPs) are effectors of host defence against infection, inflammation and wound repair. We aimed to study AMP levels in stable chronic obstructive pulmonary disease (COPD) during acute exacerbations COPD (AECOPD), examine their relation clinical parameters inflammatory markers. The 3-year Bergen Cohort Study included 433 patients 325 controls. Induced sputum was obtained analysed for the AMPs human cathelicidin (hCAP18/LL-37) secretory leukocyte protease inhibitor...
The 6-min walk test (6MWT) is an exercise that measures functional status in chronic obstructive pulmonary disease (COPD) patients and provides information on oxygen desaturation. We investigated desaturation during 6MWT as a risk factor for important COPD outcomes: mortality, frequency of exacerbations, decline lung function lean body mass. 433 were included the Bergen Cohort Study 2006–2009, followed-up 3 years. Patients characterised using spirometry, bioelectrical impedance measurements,...
Exacerbations are major contributors to morbidity and mortality in patients with chronic obstructive pulmonary disease (COPD), respiratory bacterial viral infections an important trigger. However, using conventional diagnostic techniques, a causative agent is not always found. Metagenomic next-generation sequencing (mNGS) allows analysis of the complete virome, but has yet been applied COPD exacerbations.To study virome nasopharyngeal samples during exacerbations mNGS.88 swabs from 63 Bergen...
The ongoing coronavirus disease 2019 (COVID-19) pandemic has led to the initiation of unprecedented research efforts understand pathogenesis mediated by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). More knowledge is needed regarding cell type-specific cytopathology and its impact on cellular tropism. Furthermore, novel SARS-CoV-2 mutations tropism, alternative routes entry, co-infections, virus replication kinetics along respiratory tract remains be explored in improved...
Activation of the blood coagulation system is a common observation in inflammatory diseases. The role COPD underexplored.The study included 413 patients and 49 controls from 3-year Bergen Cohort Study (BCCS). One hundred forty-eight were also examined during AECOPD. plasma markers activation, TAT complex, APC-PCI complex D-dimer, measured at baseline exacerbations by enzyme immunoassays. Differences levels between stable controls, AECOPD examined. associations later mortality negative...
Background Associations between Vitamin D3 [25(OH)D], vitamin D binding protein (VDBP) and chronic obstructive pulmonary disease (COPD) are previously reported. We aimed to further investigate these associations on longitudinal outcomes. Methods 426 COPD patients from western Norway, GOLD stage II-IV, aged 40–76, were followed every six-month 2006 through 2009 with spirometry, bioelectrical impedance measurements registration of exacerbation frequency. Serum 25(OH)D VDBP levels determined at...
The aim was to evaluate susceptibility of oropharyngeal contamination with various bronchoscopic sampling techniques. 67 patients obstructive lung disease and 58 control subjects underwent bronchoscopy small-volume lavage (SVL) through the working channel, protected bronchoalveolar (PBAL) bilateral specimen brush (PSB) sampling. Subjects also provided an oral wash (OW) sample, negative samples were gathered for each procedure. DNA encoding bacterial 16S ribosomal RNA sequenced...
Disturbances in onset and resolution of inflammation chronic obstructive pulmonary disease (COPD) are incompletely understood. Dietary polyunsaturated fatty acids (PUFAs) can be converted into lipid mediators here collectively named oxylipins. These include classical eicosanoids, but also pro-resolving mediators. A balanced production pro-inflammatory oxylipins is importance for adequate inflammatory responses subsequent return to homeostasis.Here we investigated if PUFA metabolism disturbed...
Sputum induction is a non-invasive method for obtaining measurements of inflammation in the airways. Whether spontaneously sampled sputum can be valid surrogate unknown. The aim this study was to compare levels six inflammatory markers pairs consisting induced and spontaneous on same consultation either stable state or during exacerbations chronic obstructive pulmonary disease (COPD). 433 COPD patients aged 40-76, Global initiative Obstructive Lung Disease (GOLD) stage II-IV were enrolled...
Induced and spontaneous sputum are used to evaluate the airways microbiota. Whether types can be interchangeably in microbiota research is unknown. Our aim was compare induced from COPD patients sampled during same consultation. Bergen, Norway, were followed between 2006/2010, examined stable state exacerbations. 30 delivered 36 sample pairs. DNA extracted by enzymatic mechanical lysis methods. The V3-V4 region of 16S rRNA gene PCR-amplified prepared for paired-end sequencing. Illumina Miseq...
Background Exacerbations of chronic obstructive pulmonary disease (COPD) are debilitating events and spur progression. Infectious causes frequent; however, it is unknown to what extent exacerbations caused by larger shifts in the airways' microbiota. The aim current study was analyse changes microbial composition between stable state during exacerbations, corresponding immune response. Methods sample included 36 COPD patients examined at exacerbation from Bergen Cohort studies, one patient...
Introduction AXL receptor expression is proposed to confer immune-checkpoint inhibitor (ICI)-resistance in non-small cell lung cancer (NSCLC) patients. We sought interrogate conjunction with mutational and tumor-microenvironmental features uncover predictive mechanisms of resistance ICI-treated NSCLC Methods Tumor samples from 111 patients treated ICI-monotherapy were analyzed by immunohistochemistry for tumor- immune-AXL expression. Subsets whole-exome sequencing (n = 44) imaging mass...
8011 Background: Durvalumab consolidation after chemoradiotherapy (CRT) has improved clinical outcomes in patients with unresectable stage III non-small cell lung cancer (NSCLC). Despite durvalumab treatment, a substantial proportion of relapse, while up to 20% achieve long-term survival without durvalumab. Circulating tumor DNA (ctDNA)-based minimal residual disease (MRD) detection shown promise as tool for risk-adaptive and personalized treatment strategies resectable NSCLC but is still...
Background: Organoid cultures have received much attention in recent years due to the promise of patient-derived organoid for exploration personalized cancer treatment strategies. been established from a variety malignancies; however, lack thorough histopathological analysis has limited acceptance models as translational tools. Methods: Here, we aimed establish tumor-organoid (PDTO) human non-small-cell lung (NSCLC) resection specimens and provide evaluation cultures. Results: We show that...
LBA8005 Background: A majority of patients with LS SCLC relapse after potentially curative CRT and better treatment is needed. Immunotherapy prolongs survival in extensive stage non-small cell lung cancer. We investigated whether atezolizumab (“atezo”) SCLC. Methods: Patients PS 0-2 non-progression (PD) platinum/etoposide chemotherapy concurrent twice-daily thoracic radiotherapy (TRT) 45 Gy/30 or 60 Gy/40 fractions were randomized 1:1 to observation atezo 1200 mg Q3W for 1 year, until PD...
Background The lower airway microbiota in patients with chronic obstructive pulmonary disease (COPD) are likely altered compared the healthy individuals. Information on how is affected by smoking, use of inhaled corticosteroids (ICS) and COPD severity still scarce. Methods In MicroCOPD Study, participant characteristics were obtained through standardised questionnaires clinical measurements at a single centre from 2012 to 2015. Protected bronchoalveolar lavage samples 97 controls paired-end...
Knowledge about predictors for developing hypoxemia in the course of chronic obstructive pulmonary disease (COPD) progression is limited. The objective present study was to investigate overall PaO2, a potential change PaO2 over time, and first occurrence hypoxemia.419 patients aged 40-76 years with COPD GOLD stages II-IV underwent clinical function measurements, including repeated arterial blood gases three years. Airway obstruction, lung hyperinflation, markers systemic inflammation...
BackgroundDecreased diffusing capacity of the lung for carbon monoxide (DLCO) is associated with emphysema. DLCO also related to decreased arterial oxygen tension (PaO2), but there are limited data on associations between PaO2 and computed tomography (CT) derived measures emphysema airway wall thickness.ObjectiveTo examine whether CT thickness level beyond that provided by measurements diffusion spirometry.MethodsThe study sample consisted 271 smoking or ex-smoking COPD patients from Bergen...