A5068758430- Advanced biosensing and bioanalysis techniques
- Genetics, Aging, and Longevity in Model Organisms
- Adipose Tissue and Metabolism
- Biosensors and Analytical Detection
- Dietary Effects on Health
- Cardiovascular Health and Disease Prevention
- Adipokines, Inflammation, and Metabolic Diseases
- Reproductive Physiology in Livestock
- Diet and metabolism studies
- Blood properties and coagulation
- Regulation of Appetite and Obesity
- Elasticity and Material Modeling
- MicroRNA in disease regulation
- SARS-CoV-2 detection and testing
- Molecular Junctions and Nanostructures
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer-related molecular mechanisms research
- Receptor Mechanisms and Signaling
- Coronary Interventions and Diagnostics
- Advanced Sensor and Energy Harvesting Materials
- Nitric Oxide and Endothelin Effects
- Muscle activation and electromyography studies
- Genetic and phenotypic traits in livestock
- Intracranial Aneurysms: Treatment and Complications
- Antioxidant Activity and Oxidative Stress
Yeditepe University
2016-2025
Hormel (United States)
2020-2022
Maltepe University
2020-2022
New York University Press
2022
Cambridge University Press
2022
Ghent University
2022
University of Minnesota
2020
Huazhong University of Science and Technology
2020
Orient-Institut Istanbul
2019
Amsterdam UMC Location University of Amsterdam
2011-2015
Blood is a vital reservoir housing numerous disease-related metabolites and cellular components. Thus, it also of interest for cancer diagnosis. Surface-enhanced Raman spectroscopy (SERS) widely used molecular detection due to its very high sensitivity multiplexing properties. Its real potential diagnosis not yet clear. In this study, using silver nanoparticles (AgNPs) as substrates, number experimental parameters scenarios were tested disclose the technique The discrimination serum samples...
Summary Transmissible venereal tumour (TVT) is a coitally transmitted neoplasm of dogs and common among sexually active dogs, where sexual behaviour not under control. Several treatment options are available for the tumour, with chemotherapy being most commonly employed. In this study, we investigated clinical cytological changes after weekly vincristine sulphate administration in 38 cases naturally occurring TVT. Tumours totally regressed 31 two to seven doses (mean 3.54 ± 1.01)...
Diagnostic biomarkers based on epigenetic changes such as DNA methylation are promising tools for early cancer diagnosis. However, there significant difficulties in directly and specifically detecting methylated regions. Here, we report an electrochemical sensing system magnetic nanoparticles that enable a quantitative selective analysis of the septin9 (mSEPT9) gene, which is considered diagnostic marker stage colorectal (CRC). Methylation levels SEPT9 CRC samples were successfully followed...
While inward remodeling of small arteries in response to low blood flow, hypertension, and chronic vasoconstriction depends on type 2 transglutaminase (TG2), the mechanisms action have remained unresolved. We studied regulation TG2 activity, its (sub) cellular localization, substrates, specific mode during artery remodeling. found that isolated mouse mesenteric by exogenous required presence a reducing agent. The effect depended cross-linking as indicated lack mutant TG2. cell-permeable...
Proteolytic enzymes serve important functions during dental enamel formation, and mutations in the kallikrein 4 ( KLK4) enamelysin MMP20) genes cause autosomal-recessive amelogenesis imperfecta (ARAI). So far, only 1 KLK4 3 MMP20 have been reported ARAI kindreds. To determine whether a family with hypomaturation-type defect is caused by encoding proteolytic enzymes, we performed mutational analysis on candidate genes. Mutational haplotype analyses revealed an ARAI-causing point mutation...
G protein‐coupled receptors (GPCRs) are a large family of cell surface that play critical role in nervous system function by transmitting signals between cells and their environment. They involved many, if not all, processes, dysfunction has been linked to various neurological disorders representing important drug targets. This overview emphasises the GPCRs system, which research focus members ERNEST COST action (CA18133) working group ‘Biological roles signal transduction’. First,...
Associations between the gut microbiome and colorectal cancer (CRC) have been uncovered, but larger more diverse studies are needed to assess their potential clinical use. We expanded upon 12 metagenomic datasets of patients with CRC (n = 930), adenomas 210) healthy control individuals 976; total n 2,116) 6 new cohorts 1,625) providing granular information on stage anatomic location tumors. improved prediction accuracy based solely metagenomics (average area under curve 0.85) highlighted...
<title>Abstract</title> The effects of calorie restriction (CR) on age-related epigenetic modifications have recently been exposed, yet there is a road ahead in explaining the CR regulations. Although exact mechanism(s) underlying beneficial healthy brain aging still unclear, increasing evidence suggests that are promising regulators may be involved this phenomenon. Here, we assessed long-term two different types DNA methylation levels nutrient and related <italic>Igf1r</italic>,...
The present study was carried out to search whether organophosphate pesticides affect the mechanical properties of thoracic aorta. Wistar female rats (aged 6-8 weeks) were assigned randomly a control group and groups treated with either dichlorvos or chlorpyriphos for 90 days at dose 5 mg/kg/day. After that period, animals killed aorta strips in longitudinal direction isolated. stress, strain elastic modulus obtained from strips. Our results showed chronic administration caused downward...
Abstract Calorie restriction (CR) is one of the most effective methods to prevent many diseases including cancer in preclinical models. However, molecular mechanism how CR prevents unclear. The aim this study was understand role oxidative stress (OS) preventive effects different types aging mouse mammary tumor virus‐transforming growth factor‐alpha (MMTV‐TGF‐α) female mice. Mice were enrolled ad libitum (AL), chronic (CCR, 15% CR) or intermittent [ICR, 3 weeks AL (ICR‐Refeed, ICR‐RF) and 1...
When e-textile EMG electrodes are integrated into clothing, the fit of clothing on body, and therefore its pattern cut become important factors affecting signal quality in relation to seamless contact between skin electrode. The research so far these effects was conducted commercially available or tubular sleeve forms for arms. There is no study that investigated different conditions their effect electrode performance. This investigates applications using onto sleeves custom drafted t-shirts...
While matrix remodeling plays a key role in vascular physiology and pathology, the underlying mechanisms have remained incompletely understood. We studied of collagen matrices by individual smooth muscle cells (SMCs), clusters monolayers. In addition, we focused on contribution transglutaminase 2 (TG2), which an important small arteries. Single SMCs displaced fibers at distances up to least 300 μm course 8-12 h. This process involved both 'hauling up' local compaction distance from cells,...
Adropin is a peptide hormone that has been implicated in insulin resistance and as potential regulator of growth. The aim this study to determine the effect calorie restriction on circulating levels adropin MMTV-TGFα breast cancer mouse model investigate effects viability MCF-7 MDA-231 cells culture. Ten-week-old mice were assigned either ad libitum-fed (AL), chronic calorie-restricted, or intermittent calorie-restricted groups. Concentrations serum measured using an enzyme-linked...