A5092793211- Cancer Cells and Metastasis
- 3D Printing in Biomedical Research
- Advanced Breast Cancer Therapies
- Vitamin C and Antioxidants Research
- Cancer Genomics and Diagnostics
- Transgenic Plants and Applications
- Estrogen and related hormone effects
- Vitamin D Research Studies
- Endoplasmic Reticulum Stress and Disease
- Fibroblast Growth Factor Research
- Cancer, Stress, Anesthesia, and Immune Response
Gdańsk Medical University
2023-2024
An active form of vitamin D3 (1,25-dihydroxyvitamin D3) acts through D receptor (VDR) initiating genomic response, but several studies described also non-genomic actions 1,25-dihydroxyvitamin D3, implying the role PDIA3 in process. is a membrane-associated disulfide isomerase involved bond formation, protein folding, and remodeling. Here, we used transcriptome-based approach to identify changes expression profiles PDIA3-deficient squamous cell carcinoma line A431 after treatment. knockout...
Regardless of the unprecedented progress in malignant melanoma treatment strategies and clinical outcomes patients during last twelve years, this skin cancer remains most lethal one. We have previously documented that vitamin D its low-calcaemic analogues enhance anticancer activity drugs including a classic chemotherapeutic-dacarbazine-and an antiangiogenic VEGFRs inhibitor-cediranib. In study, we explored response A375 RPMI7951 lines to CPL304110 (CPL110), novel selective inhibitor...
Despite the recent development of improved methods treating melanoma such as targeted therapy, immunotherapy or combined treatment, number new cases worldwide is increasing. It well known that active metabolites vitamin D3 and lumisterol (L3) exert photoprotective antiproliferative effects on skin, while UV radiation a major environmental risk factor for melanoma. Thus, many natural synthetic analogs steroidal secosteroidal molecules have been tested various cancer cells in animal models. In...
Abstract Liquid biopsies developed into a range of sensitive technologies aiming to analyze for example, circulating tumor cells (CTCs) in peripheral blood, which significantly deepens understanding the metastatic process. Nevertheless, examination CTCs is mostly limited their enumeration and usually only 2–3 markers‐based phenotyping, not offering yet sufficient insight biology. In contrast, quantitative analysis morphological details might extend our knowledge about dissemination even...