A5014945635- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Global Cancer Incidence and Screening
- Advances in Oncology and Radiotherapy
- Health Systems, Economic Evaluations, Quality of Life
- Palliative Care and End-of-Life Issues
- Global Health and Surgery
- Adolescent and Pediatric Healthcare
- Ethics and Legal Issues in Pediatric Healthcare
- COVID-19 and healthcare impacts
- Pharmaceutical studies and practices
- Neuroblastoma Research and Treatments
- Neutropenia and Cancer Infections
- Cervical Cancer and HPV Research
- Glioma Diagnosis and Treatment
- Child and Adolescent Health
- Medication Adherence and Compliance
- Healthcare cost, quality, practices
- Pharmaceutical Economics and Policy
- Cancer therapeutics and mechanisms
- Global Public Health Policies and Epidemiology
- Ocular Oncology and Treatments
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Research Studies
- Family Support in Illness
St. Jude Children's Research Hospital
2016-2025
Huntsman Cancer Institute
2025
University of Utah
2025
Erasmus University Rotterdam
2023
Erasmus MC
2023
University of Tennessee Health Science Center
2014-2020
University of Tennessee at Knoxville
2016-2018
Children's Hospital of Philadelphia
2018
Baptist Hospital
2017
Moi University
2017
Background Understanding and addressing treatment abandonment (TxA) is crucial for bridging the pediatric cancer survival gap between high-income (HIC) low-and middle-income countries (LMC). In childhood cancer, TxA defined as failure to start or complete curative therapy known be a complex phenomenon. With rising interest on causes consequences of in LMC, this study aimed establish lay-of-the-land regarding determinants globally, perform promote comparative research, raise awareness...
Background Treatment abandonment (TxA) is recognized as a leading cause of treatment failure for children with cancer in low-and-middle-income countries (LMC). However, its global frequency and burden have remained elusive due to lack data. This study aimed obtain an estimate using survey population Methods Childhood clinicians (medical oncologists, surgeons, radiation therapists), nurses, social workers, psychologists involved care were approached through online February-May 2012. Incidence...
Neuroblastoma is the most common extracranial solid tumor in childhood high‐income countries (HIC), where consistent treatment approaches based on clinical and biological risk stratification have steadily improved outcomes. However, low‐ middle‐ income (LMIC), suboptimal diagnosis, stratification, may occur due to limited resources unavailable infrastructure. The practice guidelines outlined this manuscript are current published evidence expert opinions. Standard explicitly adapted graduated...
Abstract Many children with cancer in low‐ and middle‐income countries are treated hospitals lacking key infrastructure, including diagnostic capabilities, imaging modalities, treatment components, supportive care, personnel. Childhood regimens adapted to local conditions provide an opportunity cure as many possible the available resources, while working improve services care. This paper from Adapted Treatment Regimens Working Group of Pediatric Oncology Developing Countries committee...
Intravenous immunoglobulin (IVIg) is an adjunctive therapy for juvenile dermatomyositis (JDM) patients with poor response to first-line (corticosteroid resistant; SR) or who are corticosteroid dependent (SD). Patients requiring IVIg generally expected have poorer outcomes, leading confounding by indication in observational studies. Few studies evaluated efficacy JDM.Compared similar matched controls, determine if JDM recipients achieve quiescence sooner and less disease activity. For SD...
Abstract Tuberous sclerosis complex (TSC) is associated with hamartomatous growths including subependymal giant cell astrocytomas (SEGAs). Since chemo‐radiation therapies offer scant benefit, oncologists had traditionally been little involved in managing SEGAs. Recent evidence demonstrating rapamycin efficacy adults and children TSC‐associated tumors foresee a practice change. We summarize our institutional experience literature review that highlight potential benefits hazards of therapy,...
Purpose The clinical features, pathogenesis, and outcomes in children with adrenocortical tumors (ACTs) without germline TP53 mutations have not been systematically studied. Herein, we describe these correlates analyze their association outcome. Patients Methods Genomic DNA was analyzed for TP53, CTNNB1, CDKN1C, ATRX, chromosome 11p15 abnormalities. β-catenin expression Ki-67 labeling index (LI) were evaluated by immunostaining. Primary end points progression-free (PFS) overall survival....
Abstract Objective To determine the relative discriminant validity of 3 new versions Childhood Health Assessment Questionnaire (CHAQ) and to concordance between children their parents. Methods The parents 48 with musculoskeletal disability 101 nondisabled controls were given CHAQ revised in random order. Children older than 5 years also completed questionnaires. Results All more sensitive at differentiating patients from (relative efficiency 1.35–1.65); 8 added items even 1.79–2.32)....
Background In El Salvador, about 200 new cases of pediatric cancer are diagnosed each year, and survival rates approach 70%. Although treatment is available at no cost, abandonment therapy has remained a steady yearly rate 13% during the past decade. A time sensitive adherence tracking procedure (TS‐ATP) was recently implemented to detect missed appointments, identify their causes, intervene promptly. Procedure The study team informed daily patient/family failure attend medical appointments...