A5100385113- Toxoplasma gondii Research Studies
- RNA Interference and Gene Delivery
- Cancer-related gene regulation
- Herpesvirus Infections and Treatments
- Reproductive System and Pregnancy
- Oral Health Pathology and Treatment
- Cytomegalovirus and herpesvirus research
- Endodontics and Root Canal Treatments
- Renal and related cancers
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Virus-based gene therapy research
- Kruppel-like factors research
- Drilling and Well Engineering
- Immunotherapy and Immune Responses
- Galectins and Cancer Biology
- Xenotransplantation and immune response
- HIV/AIDS drug development and treatment
- Genetic factors in colorectal cancer
- Dialysis and Renal Disease Management
- Oral and Maxillofacial Pathology
- MicroRNA in disease regulation
- Oral and gingival health research
- HIV Research and Treatment
Tsinghua University
2025
Dalian Medical University
2023
King Abdullah University of Science and Technology
2021
Huazhong Agricultural University
2018-2020
First Affiliated Hospital of Harbin Medical University
2019
Harbin Medical University
2019
First Affiliated Hospital of Zhengzhou University
2016-2018
Targeted protein delivery with nanocarriers holds significant potential to enhance therapeutic outcomes by precisely directing proteins specific organs or tissues. However, the complex interactions between and biological environment pose considerable challenges in designing effective targeted vehicles. In this study, we address challenge leveraging DNA-barcoded high-throughput screening. We construct a nanocapsule library via in-situ polymerization, incorporating various monomers create...
Toxoplasma gondii is an apicomplexan protozoan parasite that can cause serious clinical illnesses in both humans and animals. microRNAs (miRNAs) are non-protein-coding RNAs regulate the expression of target genes. A previous study found many miRNAs were differentially expressed after T. infection exert significant effects revealed host survival virulence different strains be regulated by miRNAs. Macrophages play important role infection, but few studies have investigated relationship between...
We recently demonstrated that a co-culture system of human umbilical vein endothelial cells (HUVECs) and dental pulp stem (hDPSCs) could enhance angiogenesis ability in vitro. However, whether tumor necrosis factor α (TNF-α) promote blood vessel formation during regeneration remained unknown. The aim this study was to investigate the effects TNF-α on tubules vascular networks hDPSCs HUVECs. were co-cultured with HUVECs at ratio 1:5. Matrigel assay performed detect total tubule branching...
Abstract Oral lichen planus (OLP) is a severe T cell–mediated disorder of the mucosa, which causes chronic inflammation. Forkhead box P3 (Foxp3) regulates immune response and plays an important role in immunological diseases. The current study aimed to determine Foxp3 microRNA (miR)‐146a OLP. Western blot analysis quantitative real‐time polymerase chain reaction assay showed that expression miR‐146a was upregulated OLP tissues lipopolysaccharide (LPS)‐incubated HaCaT cells, compared with...
Toxoplasma gondii is a protozoan parasite, occurring worldwide, endangers human health and causes enormous economic losses to the Ministry of Agriculture. A safe effective vaccination needed handle these problems. In addition, ideal vaccine production challenge in future. this study, we knocked out adenylosuccinate lyase (ADSL) gene found that reduces growth rate T. tachyzoites vitro under standard conditions by plaque or replication experiments. Furthermore, mice were immunized with...
Embryo implantation into the uterus is gateway for successful pregnancy. Proper migration and invasion of embryonic trophoblast cells are key embryo implantation, dysfunction causes pregnancy failure. Protein glycosylation plays crucial roles in reproduction. However, it remains unclear whether trophoblasts involved processes during By Lectin array, we discovered decreased α1,3-fucosylation, especially difucosylated Lewis Y (LeY) glycan, villus tissues miscarriage patients when compared with...
Toxoplasma gondii (T. gondii) is a zoonotic parasite that severely harms the health of host. The cysts T. can reactivate from bradyzoites to tachyzoites, if individual develops low or defective immunity, causing lethal toxoplasmosis. host resists infection by mediating Th1-type cellular immunity generate pro-inflammatory cytokines. Tumor necrosis factor (TNF) an important cytokine, which induce lysosomal fusion parasitophorous vacuole kill parasites. Etanercept soluble TNF receptor protein,...
The Nef protein of human and simian immunodeficiency viruses boosts viral pathogenicity through its interactions with host cell proteins. By combining the polyvalency large unstructured regions binding selectivity strength folded core domain, can associate many different proteins, thereby disrupting their functions. For example, combination a linear proline-rich motif hydrophobic domain surface allows to bind tightly specifically SH3 domains Src family kinases. We investigated whether...
Abstract Embryonic trophoblast implanting into the uterus is gateway for successful pregnancy. Dysfunctions of cause pregnancy failure. Protein glycosylation plays crucial roles in reproduction process. However, it remains unclear if trophoblasts involves embryo implantation. By glycomics, proteomics combined with translatomics, our results revealed that decreased α1,3-fucosylation, especially difucosylated Lewis Y (LeY) glycan, villus miscarriage patients compared normal women....