A5103113944- Cancer-related molecular mechanisms research
- Arsenic contamination and mitigation
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Retinoids in leukemia and cellular processes
- Circular RNAs in diseases
- RNA modifications and cancer
- Lung Cancer Research Studies
- Immune Cell Function and Interaction
- Parkinson's Disease Mechanisms and Treatments
- Heavy Metal Exposure and Toxicity
- Gastric Cancer Management and Outcomes
- Selenium in Biological Systems
- Ovarian cancer diagnosis and treatment
- 14-3-3 protein interactions
- Glioma Diagnosis and Treatment
- Toxin Mechanisms and Immunotoxins
- Esophageal and GI Pathology
- Neonatal Respiratory Health Research
- Esophageal Cancer Research and Treatment
- Retinal Development and Disorders
- Vascular Tumors and Angiosarcomas
- Hippo pathway signaling and YAP/TAZ
- Biliary and Gastrointestinal Fistulas
- Colorectal Cancer Screening and Detection
Fujian Provincial Hospital
2024-2025
Fuzhou University
2024-2025
Fujian Medical University
2024-2025
Third Affiliated Hospital of Zhengzhou University
2024
Guangxi Medical University
2020-2024
Fudan University
2010-2023
Zhongshan Hospital
2023
First People's Hospital of Foshan
2020-2021
Sun Yat-sen University
2020-2021
Tumor Hospital of Guangxi Medical University
2020
Abstract Aims BACH1 is up-regulated in hypertrophic hearts, but its function cardiac hypertrophy remains largely unknown. This research investigates the and mechanisms of regulation hypertrophy. Methods results Male cardiac-specific knockout mice or transgenic (BACH1-Tg) their respective wild-type littermates developed induced by angiotensin II (Ang II) transverse aortic constriction (TAC). Cardiac-specific protected hearts against Ang II- TAC-induced fibrosis, preserved function....
SPTBN1 plays an anticancer role in many kinds of tumors and participates the chemotherapeutic resistance epithelial ovarian cancer (EOC).Here, we reported that lower expression was significantly related to advanced EOC stage shorter progression-free survival.SPTBN1 also higher less invasive cell lines.Moreover, decreased migration ability cells A2780 HO8910 inhibited growth vitro tumor xenografts vivo.SPTBN1 suppression increased mesenchymal transformation marker Vimentin while decreasing...
Purpose Gastric cancer (GC) is associated with rapid disease progression and poor patient prognosis, highlighting the pressing need for new biomarkers to facilitate management. Exosomes are released by all cells ubiquitous in body fluids, thus giving them great potential as diagnostic therapeutic targets. MicroRNAs (miRNAs) can be transported exosomes, a common target regulation cancer. Methods Our screen of miRNAs Gene Expression Omnibus The Cancer Genome Atlas databases identified...
NK cells play a vital role in tumor immune resistance. Various factors affect cell activity. While dysfunction has been observed numerous malignancies, the underlying mechanisms gastric cancer remain unclear. Flow cytometry was used to identify phenotypic distribution and expression of activated receptors on cells. ELISA determine cytokines. We examined cell-related genes explored their association with survival prognosis. Additionally, we conducted PCR detection miR-552-5p levels plasma...
Loss of Spectrin beta, non-erythrocytic 1 (SPTBN1) plays an important role in the carcinogenesis hepatocellular carcinoma (HCC); however, mechanisms underlying its involvement remain poorly understood. Defects autophagy contribute to hepatic tumor formation. Hence, this study, we explored and mechanism SPTBN1 stem cells (HSCs) HCC cells.Expansion, autophagy, malignant transformation HSCs were detected injured liver Sptbn1+/- mice induced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine...
Gastric cancer (GC) is one of the most common malignant tumors. More and more evidences support role microRNAs (miRNAs) in tumor progression. However, miRNAs human GC remains largely unknown.Based on published gastric expression profile data, combined with bioinformatics analysis, potential process were screened. The miR-199b-5p cells patients' plasma was detected by RT-PCR. effects vitro EdU proliferation assay, colony formation Transwell assay wound healing assay. Western blot used to...
Abstract Tumor‐associated macrophages (TAMs) are the most abundant immune cells in tumor microenvironment, and M2‐type TAMs can promote growth, invasion angiogenesis, suppress antitumor responses. It has been reported that spectrin beta, non‐erythrocytic 1 (SPTBN1) may inhibit infiltration of Sptbn1 +/− mouse liver, but whether SPTBN1 affects polarization remains unclear. This study investigated effect mechanism cell on migration hepatoma breast cancer. By analyzing databases, we found a...
Background: Long non-coding RNAs (lncRNAs) reportedly play important roles in biomarker and tumorigenesis of gastric cancer (GC). This study aimed to determine the potential application prognostic lncRNA signature identified role LINC01614 carcinogenesis GC. Material Methods: Data accessed from Cancer Genome Atlas database was used construct a signature. Joint effect analysis clinical parameters performed verify value Co-expression conducted for lncRNAs protein-coding genes. Moreover,...
Gastric cancer (GC) is among the most common forms of affecting digestive system. This study sought to identify hub genes regulating early GC (EGC) in order explore their potential for diagnosis and prognosis patients.We utilized a publically available dataset from Gene Expression Omnibus database (GSE55696). Differences between EGC LGIN with respect gene expression were compared using limma software. Identified differentially expressed (DEGs) subjected ontology (GO) pathway enrichment...
A 33-year-old woman presented with a 3-month history of upper abdominal pain, which was exacerbated by bending or twisting. Blood tests revealed no abnormalities, and pharmacological interventions failed to alleviate symptoms. Gastroscopy at local hospital had shown 0.6-cm firm protrusion on the greater curvature gastric antrum, without discoloration texture changes, that suspicious for submucosal tumor (SMT) ([Fig. 1] a). However, gastroscopy our center lesion shrunk in size compared...
Peripheral neurotoxicity is a disturbing issue for cancer patients who are treated with chemotherapy. Several medications have been developed preventing chemotherapy-induced chronic (CICNT) however; their relative efficacies not yet studied. In this study, we conducted network meta-analysis to give intervention recommendations. The literature was searched in variety of databases and eligible studies were chosen based on predefined criteria. Data extraction statistical analysis performed the...
Abstract Arsenic is a proven human carcinogen. Although the mechanism of its carcinogenicity still largely unknown, methylation thought to have an important role play in arsenic toxicity. In this study, urinary profiles were investigated female C57BL/6J black mice given drinking water containing 500 μg arsenate (As V )/L, 250 As /L, or 100 /L as sodium for 2 months. The concentrations chosen reflected those often encountered arsenic‐endemic areas. Urine samples collected from at end exposure...
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide and third leading cause cancer-related death. MicroRNAs transcription factors (TFs) cooperate to regulate same target gene, thus affecting progression HCC.Differentially expressed miRNAs mRNAs were screened. Functional enrichment analysis these HCC-related was performed, a protein-protein interaction network constructed. TFs that hub genes also screened.Ten differentially upregulated 5 downregulated Additionally,...
<title>Abstract</title> <bold>Objective</bold> NK cells play a vital role in tumor immune resistance. Various factors affect cell activity. While dysfunction has been observed numerous malignancies, the underlying mechanisms gastric cancer remain unclear.<bold>Method</bold> Flow cytometry was used to identify phenotypic distribution and expression of activated receptors on cells. ELISA determine cytokines. We examined cell-related genes explored their association with survival prognosis....