A5079216309- Urticaria and Related Conditions
- Contact Dermatitis and Allergies
- Allergic Rhinitis and Sensitization
- Drug-Induced Adverse Reactions
- Dermatology and Skin Diseases
- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- Autoimmune Bullous Skin Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Mast cells and histamine
- Occupational exposure and asthma
- Inflammatory mediators and NSAID effects
- Immunodeficiency and Autoimmune Disorders
- Pesticide Exposure and Toxicity
- Sinusitis and nasal conditions
- Nail Diseases and Treatments
- Respiratory and Cough-Related Research
- SARS-CoV-2 and COVID-19 Research
- Blood disorders and treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Eosinophilic Disorders and Syndromes
- Transgenic Plants and Applications
- Complement system in diseases
- Pharmaceutical studies and practices
University of Bari Aldo Moro
2016-2025
Azienda Universitaria Ospedaliera Consorziale - Policlinico Bari
2022-2023
John Wiley & Sons (United Kingdom)
2022
Oxfam
2022
John Wiley & Sons (United States)
2022
University of Turin
2018-2020
National Research Council
2020
Ospedale San Carlo
2020
Azienda Ospedaliero-Universitaria Careggi
2020
Azienda Ospedaliero Universitaria Ospedali Riuniti
2020
Abstract This evidence‐ and consensus‐based guideline was developed following the methods recommended by Cochrane Grading of Recommendations Assessment, Development Evaluation ( GRADE ) working group. The conference held on 1 December 2016. It is a joint initiative Dermatology Section European Academy Allergology Clinical Immunology EAACI ), EU ‐founded network excellence, Global Allergy Asthma Network GA ² LEN Forum EDF World Organization WAO with participation 48 delegates 42 national...
Chronic spontaneous urticaria (CSU) is defined as occurrence of wheals and/or angioedema for ≥6 weeks. Omalizumab a monoclonal anti-IgE antibody effective in refractory CSU, but its mechanism action and markers predictive response remain not completely defined.To correlate baseline levels two proposed biomarkers, total IgE (bIgE) d-dimer (bd-dimer), clinical parameters to omalizumab relapses after drug withdrawal.In this retrospective Italian multicentre study, data were collected 470 CSU...
Treatment of moderate-to-severe atopic dermatitis (AD) in the elderly may be challenging, due to side-effects traditional anti-inflammatory drugs and comorbidities often found this age group. Furthermore, efficacy safety innovative such as dupilumab are not yet well known.A multicentre retrospective, observational, real-life study on was conducted a group patients aged ≥65 years affected by severe AD. Their main clinical features were also examined.Data with (EASI ≥24) AD treated at label...
There is limited epidemiological evidence on outcomes associated with dupilumab exposure during pregnancy; monitoring pregnancy in large populations required.
Contact dermatitis is the most frequent occupational dermatosis and non-specific irritants in addition to specific Type IV sensitization are involved. We reviewed our database for data from 1994 1998 selected 360 consecutive patients working healthcare environments experiencing contact at their hands, wrists forearms. found that allergic irritant were considered be work-related 16.5% (72/436) 44.4% (194/436) of diagnoses, respectively. Occupational due exposure a wide range workplace, such...
Chronic urticaria (CU) is a common skin condition. It frequently disabling disease due to the persistency of clinical symptoms, unpredictable course and negative influence on quality life.The aim this study determine whether montelukast, LTD4 receptor antagonist, plus desloratadine, more efficacious than desloratadine alone in treatment chronic urticaria.A randomized, double-blind, placebo-controlled was conducted 81 patients with diagnosis CU. A 1-week single-blind placebo run-in period...
Background: Dupilumab has proven to be an effective treatment for patients with moderate-to-severe atopic dermatitis (AD) in clinical trials. However, real-world experience dupilumab a broader population is limited. Methods: The study comprised adult AD, defined as Eczema Area Severity Index (EASI) score of 24 or higher, treated at 10 Italian teaching hospitals. We analyzed physician-reported outcome measures (EASI), patient-reported (pruritus and sleep score, Dermatology Life Quality...
Moderate-to-severe atopic dermatitis (AD) in the adolescence is a high burden disease, and its treatment can be very challenging due to paucity of approved systemic drugs for this age their side-effects. Dupilumab was recently adolescent AD.A multicentre, prospective, real-world study on effectiveness safety dupilumab adolescents (aged from ≥12 <18 years) with moderate-to-severe AD conducted. The main clinical phenotypes were also examined.Data treated at label dosage 16 weeks collected....
Abstract Background Biologics are currently one of the main treatment options for a number diseases. The IgG4 monoclonal antibody dupilumab targets Interleukin-4 receptor alpha chain, thus preventing biological effects cytokines IL-4 and IL-13, that essential Th2 response. Several controlled trials showed is effective safe in patients with atopic dermatitis (AD), severe asthma chronic rhinosinusitis nasal polyps (CRSwNP), resulting approval by regulatory agencies. Aim study was to evaluate...
Abstract Background Eyelid dermatitis is a frequent reason of dermatological consultation. Its aetiology not univocal, being contact dermatitis, both allergic and irritant, the most frequent. The primary sources allergen exposure include cosmetics, metals, topical medications, from direct, indirect, or airborne contact. Objectives To define frequency positive patch test reactions to SIDAPA baseline series allergens, document precise final diagnosis in patients with eyelid involvement....
It has been established that there are type I and IV allergens in latex gloves.The purpose of the study was to establish prevalence rubber glove-induced skin symptoms among health care workers one Italian hospital.Health (n = 1584) were evaluated using a written questionnaire 295 respondents with tested. We performed: prick test glove extract commercial latex, environmental food allergens; use test; patch tests additive series; RASTs.Hospital employees who used or had gloves at work 1294....
Background The IgE response is directed against specific components from an allergenic source. traditional diagnostic methods use whole extracts, containing allergenic, nonallergenic and cross-reactive molecules. This may pose challenges in polysensitized patients. Microarray techniques detect multiple molecules, but their value term of additional information economic saving has not been yet defined. Objective We assessed the provided by allergen microarray a large population subjects....
Additional data supporting the findings of this manuscript are available on reasonable request to corresponding author.
In the field of severe asthma, concept disease control has recently been integrated by one clinical remission. With this new concept, we move on to analyze efficacy therapy multiple parameters simultaneously, starting with mandatory discontinuation systemic glucocorticoids, which is added effect exacerbations, respiratory function, and symptoms control. The Italian asthma registry SANI (Severe Asthma Network Italy) drafted criteria for definition remission, allowing patients be classified...
Urticaria is a common disorder that affects as many 20% of all people at some time during their lifetime.To analyse the prevalence various forms urticaria according to an aetiological and clinical classification, we carried out 4-year study in outpatient clinic.The was on 562 consecutive patients (178 males 384 females; mean age 35.4 +/- 16), who had been referred our unit for angio-oedema. Baseline investigations included: patient's family personal history allergy; duration symptoms,...
Natural rubber latex (NRL) allergy is a worldwide problem. Although prevention sufficient to reduce sensitization, prolonged avoidance needed prevent resensitization or adverse reactions on re-exposure.This double-blind, placebo-controlled study was conducted determine the efficacy of sublingual immunotherapy (SLIT) with latex.Forty patients NRL were enrolled. At diagnosis, 30 presented urticaria and 10 asthma. Patients evaluated their clinical history an allergological assessment: skin...
Summary Background Subcutaneous immunotherapy is effective for the treatment of respiratory allergy, and it largely used in Italy, but no systematic safety assessment has been carried out so far. Objective To assess prospectively injection a multicentre, real‐life survey. Methods Eleven Italian allergy departments recorded clinical characteristics systemic reactions (SRs) due to immunotherapy. Vaccines were prescribed according guidelines; only standardized depot extracts used. SRs graded...