Na segodnyashnij den' aktualen analiz riska razvitiya serdechno-sosudistyh oslozhnenij u pacientov s gipertonicheskoj bolezn'yu (GB) posle perenesennoj novoj koronavirusnoj infekcii (COVID-19). Pokazana znachimost' lejkemiya-ingibiruyushchego faktora (LIF) i ego rastvorimogo receptora (sLIFr) v progressirovanii GB aktual'nost' cirkadiannyh podhodov ocenke vklada provospalitel'nyh citokinov patogenez ostrogo narusheniya mozgovogo krovoobrashcheniya (ONMK). Cel'yu issledovaniya bylo...

Today, the analysis of risk developing cardiovascular complications in patients with essential hypertension (EH) following recovery from novel coronavirus infection (COVID-19) is relevant. The value leukemia inhibitory factor (LIF) and its soluble receptor (sLIFr) EH progression has been shown, along relevance circadian approaches to assessment contribution pro-inflammatory cytokines pathogenesis acute cerebrovascular accidents (CVA). study aimed compare alterations LIF sLIFr levels during...

The purpose of the study is to analyze and substantiate relationship mucosal immunity oral mucosa senior schoolchildren indicator cytokines their correlation with inclusion fish in school meals for prevention seasonal acute respiratory diseases (ARI) 2nd half year. immune system an autonomous subsystem immunity. It has its own characteristics different departments. most studied is: esophagus, stomach, small intestine (CALT).The necessity developing a high-quality diet mandatory it...

The purpose of this research is to study the characteristics change in circadian rhythm macrophage colony-stimulating factor (M-CSF) content peripheral blood serum patients with stage II essential hypertension (EH) based on 5 time points (8:00, 14:00, 20:00, 2:00, and 8:00) analyze its connection frequency cardiovascular events.Identified levels M-CSF 60 EH, before after 1 year antihypertensive therapy using enzyme-linked immunoassays (at 8:00, 8:00).The demonstrated that EH a medical case...

The article presents modern scientific data on long-term clinical and pathogenetic effects of the antiviral drug Areplivir (Favipiravir) in patients with metabolic syndrome post-COVID period. aim is to study cytokine-mediated (IL-6/sIL6r LIF/sLIFr) favipiravir (Areplivir®) based incidence complications Material methods. With approval local ethics committee at N.P. Ogarevs Mordovia State University (Protocol No. 5 dated May 17, 2020) “An open prospective comparative Areplivir® effectiveness...

Essential hypertension (EH) is one of the most common modifiable risk factors for cardiovascular diseases and death. The aim this study was to investigate a correlation between levels some cytokines (interleukins, adhesion molecules, tumor necrosis growth factors, etc.) in peripheral blood patients with stage II EH rate complications (myocardial infarction, acute cerebrovascular events, transient ischemic attacks) occurring 5-year follow-up period. Twenty-eight were measured using ELISA,...

In this paper, the erythrocytes of healthy donors and people with a confirmed diagnosis COVID-19 were tested by Raman spectroscopy laser interference microscopy. We argue that (red blood cells) in patients have an irregular shape, their morphometric characteristics are impaired comparison to red cells. also allows us detect decreased oxygen transport function these erythrocytes. The combination methods—Raman microscopy—is highly effective method for SARS-CoV-2.

In many ways, arterial hypertension and obesity determine the likelihood of a severe course lethal outcomes in COVID-19. This fact justifies expediency an early use drugs with direct antiviral action, analysis their efficacy not only acute, but also postcovid period. The aim research was to analyze outpatient cards case histories COVID-19 patients study effect (up 5 th day after onset first symptoms disease) drug based on favipiravir, frequency patients’ hospitalizations obesity, as well...

Currently, there are data that make it possible to speak about a high clinical efficacy of the use succinic salt tyrosyl-D-alanyl-glycyl-phenylalanyl-leucyl-arginine (hexapeptide succinate) for COVID-19 treatment. This article is devoted results trials original Russian drug based on it. The aim study was evaluate efficacy, safety and tolerability intramuscular inhalation hexapeptide succinate in complex therapy comparison with standard patients moderate COVID-19. Materials methods. research...

The aim of the study was to evaluate efficacy and safety an RNA double-stranded sodium salt drug, a lyophilisate for solution preparation intramuscular subcutaneous administration, as means post-exposure COVID-19 prophylaxis in comparison with placebo. Material methods. A double-blind, placebo-controlled, multicenter, randomized phase III clinical trial conducted drug (RADAMIN ® VIRO), preparing administration COVID-19. 10 research centers Russian Federation from May 31, 2022 January 17,...

УДК 616-092.12ЦИРКАДИАННЫЕ РИТМЫ ЦИТОКИНОВ Радаева О.А. 1 , Костина Ю.А. Солодовникова Г.А. Анашкина Е.В. Искандярова М.С. Негоднова Машнина

Nesmotrya na bol'shoe chislo issledovanij, posvyashchennyh kolichestvennym harakteristikam citokinovogo profilya pacientov s razlichnymi zabolevaniyami, net tochnyh referensnyh intervalov, i chto ne menee vazhno, ogranicheno analiziruyushchih cirkadiannye ritmy sinteza citokinov u lic arterial'noj gipertenziej. Cel'yu raboty bylo proanalizirovat' osobennosti cirkadiannyh ritmov soderzhaniya (IL18, IL18 BP, LIF, sLIFr, M-CSF, MCSFR) v krovi essencial'noj gipertenziej II stadii vydelit'...

Primary immunodeficiencies (PIDs) are a group of hereditary diseases in which individual parts the immune system do not function properly. Most often, patients first present with clinical symptoms childhood, but some defects may be recognized until later life, such as common variable deficiency (CVID). The desire to have child people suffering from PID accompanied by fear complications mother and birth immunodeficiency. Management pregnancy women is recommended joint participation an...

The search for predictors of the severe course COVID-19 was relevant both during pandemic and at present time. aim study to analyze relationship cytokine levels in patients with EН before SARS-CoV-2 infection incidence coronavirus pneumonia. Materials methods. From database 290 stage II EAG who have been under observation 8–12 years annual blood sampling determine levels, survivors were selected (mild without pneumonia moderate severe, CT 1–2, CT-3). Anamnestic IL-1β, IL-1α, IL-1ra, IL-18,...

The COVID-19 pandemic, caused by the SARS-CoV-2 virus, had a profound impact on global health, and society become one of deadliest in history. Knowledge risk factors for mortality is critically important formation organizational, methodological clinical decisions to limit disease progression reduce number fatal outcomes. However, it still unclear whether generally accepted can be equally useful identifying groups diverse population patients small cities. Aim: To evaluate utility demographic,...

Since the beginning of pandemic, repeated attempts have been made to develop etiotropic therapy for a novel coronavirus infection. Hydroxychloroquine, lopinavir/ritonavir, etc. derivatives were used as antiviral agents, however, they demonstrated low efficiency and an insufficient safety. In this connection, other groups drugs with more effective safe pharmacological profile are currently being actively used. The aim study was analyze literature references on efficacy safety COVID-19...

Background . Primary agammaglobulinemia is the result of specific changes in B-cells that lead to low antibody production. A preliminary diagnosis established if there a history frequent bacterial infections (otitis media, sinusitis, skin abscesses), including severe course, some cases caused by opportunistic flora and atypical mycobacteria; levels immunoglobulins. The main symptoms primary immunodeficiency child from this clinical example were recidivating bronchial obstruction with...

Understanding changes in the cytokine-mediated mechanisms immunopathogenesis of essential hypertension (EH) after COVID-19 poses a pressing scientific issue. SARS-CoV-2 exerts direct effects on macrophages with high probability altering regulatory M-CSF-VEGF-A-IL-34 axis, thereby accounting for change patterns progression. Immunopathogenesis complications infection and role M-CSF EH pathogenesis justify study objective – to compare serum VEGF-A, IL-34 levels stage II patients prior one month...

Pathogenetic progression mechanisms in the SARS-CoV-2–essential hypertension (EAH) system are more complex than interaction at level of angiotensinconverting enzyme 2 (ACE2). The study was aimed to assess dynamic changes IL1 members (IL1β, IL1α, IL1ra, IL18, IL18BP, IL37) blood levels patients with EAH 10, 30, and 180 days after having COVID-19 order define cytokine-mediated during period following infection. involved four groups patients: a history (pneumonia/no pneumonia), pneumonia) no...

Журнал для непрерывного медицинского образования врачей Анализ данных о механизме действия и эффективности препаратов

Today, increasing attention is being paid to the role of circadian rhythms in pathology. There are time-of-day-dependent immune markers that provide valuable information about disease progression. The aim this study was measure evening and morning concentrations a few cytokines (interleukins, adhesion molecules, tumor necrosis/growth factors, etc.) peripheral blood patients with stage II essential hypertension investigate how they correlate nocturnal pressure decline. Blood samples were...