A5103183093- Pediatric health and respiratory diseases
- COVID-19 Clinical Research Studies
- Immune responses and vaccinations
- SARS-CoV-2 and COVID-19 Research
- Sinusitis and nasal conditions
- Respiratory viral infections research
- Long-Term Effects of COVID-19
- Antimicrobial Peptides and Activities
- Tryptophan and brain disorders
- Immune Response and Inflammation
- Asthma and respiratory diseases
- Inflammasome and immune disorders
- Mental Health and Psychiatry
- Psychotherapy Techniques and Applications
- Biochemical effects in animals
- Salivary Gland Disorders and Functions
- Angiogenesis and VEGF in Cancer
- Redox biology and oxidative stress
- Allergic Rhinitis and Sensitization
- Psychiatric care and mental health services
- Diagnosis and Treatment of Venous Diseases
- Wound Healing and Treatments
- Immunodeficiency and Autoimmune Disorders
- Synthesis and Biological Evaluation
- Eicosanoids and Hypertension Pharmacology
State Research Institute of Highly Pure Biopreparations
2014-2025
First Pavlov State Medical University of St. Petersburg
2024
Saint Petersburg Pasteur Institute
2024
Federal Medical-Biological Agency
2015-2021
The leading factors in the pathogenesis of chronic polyposis rhinosinusitis (CRSwNP) are dysfunction epithelial barrier nasal and sinus mucosa dysregulation immune system, both at systemic local levels. A Th2-mediated response plays a central role development disease patients with CRSwNP CRPS, is often associated bronchial asthma (BA). At present time, for conservative treatment CRSwNP+BA, preference given to drug therapy aimed correction mucosal immunity. use interferon α2β (IFN α2β)...
Novel coronavirus disease 2019, caused by the SARS-CoV-2, initiate humoral and cellular immune responses against diverse virus antigens. The assessment of SARS-CoV-2-specific is mainly carried out in routine practice determining specific immunoglobulins. However, high variability S-protein structure new genovariants SARS-CoV-2 lack correlation between antibodies CD8+ T-lymphocytes underlie false negative responses, mass immunity complicated due to complexity applying ELISPOT cytofluorometry...
Objective: to study the dynamics of local and systemic cytokine production in children with different clinical forms acute respiratory viral infections (ARVI), including COVID-19, assess effectiveness interferon-based therapy. Patients methods: The included 180 patients aged from 1 month 17 years сonfirmed COVID-19. were divided into 2 groups (main control) 90 people each. In main group received intranasal medicine Grippferon ® addition basic therapy, control only status was assessed by...
Treatment of chronic wounds is a difficult problem contemporary surgery. An opportunity curing these by means cytokines, such as interleukin-1 (IL-1), an issue great interest. A clinical trial IL-1β was performed in the patients with different origin. Recombinant human applied six ointment compositions containing active drug (0.05 to 5000 ng/ml) using hydrophobic vehicle. The preparations were used treat non-healing and trophic ulcers diseases lower extremities complicated venous...
The search for predictors of the severe course COVID-19 was relevant both during pandemic and at present time. aim study to analyze relationship cytokine levels in patients with EН before SARS-CoV-2 infection incidence coronavirus pneumonia. Materials methods. From database 290 stage II EAG who have been under observation 8–12 years annual blood sampling determine levels, survivors were selected (mild without pneumonia moderate severe, CT 1–2, CT-3). Anamnestic IL-1β, IL-1α, IL-1ra, IL-18,...
Known methods of treating chronic polypous rhinosinusitis do not have a significant effect on the progressive nature disease. Recently, anticytokine therapy has been developed and introduced. However, high cost drugs complexity their production make it necessary to search for other with similar mechanisms action. Such immunotropic can be recombinant IFNα-2b γ-D-glutamyl-L-tryptophan. The aim study is mechanism action evaluate effectiveness local application γ-D-glutamyl-L-tryptophan in...
Here, we present the results of a limited, blind, placebo-controlled study examining effect multi-component preparation Glucaferon consisting primarily beta-glucans obtained from edible Oyster mushroom, and biologically active substances with verified antioxidant anti-inflammatory activity on effectiveness routine therapy for moderate-to-severe acute SARS-CoV-2-caused infection. There were enrolled 60 subjects (males females) aged 18 to 75 years, who received 10-day-long in accordance...
The task in treating acute nasopharyngitis (ANP) deals with reducing the disease symptoms and risk of complications. lack reliable antiviral drugs makes it important to search for appropriate medicines among other pharmacotherapeutic groups. study involves a comparative analysis efficiency estimates potential: recombinant interferon α2b compound containing fungal β-D-glucans used treat ANP studies involved patients from 18 55 years old. As many as 152 people were examined including...
Pathogenetic progression mechanisms in the SARS-CoV-2–essential hypertension (EAH) system are more complex than interaction at level of angiotensinconverting enzyme 2 (ACE2). The study was aimed to assess dynamic changes IL1 members (IL1β, IL1α, IL1ra, IL18, IL18BP, IL37) blood levels patients with EAH 10, 30, and 180 days after having COVID-19 order define cytokine-mediated during period following infection. involved four groups patients: a history (pneumonia/no pneumonia), pneumonia) no...
Abstract. Features of IgG and IgE immune response for opportunistic microbes pharynx biotope in children with pharyngeal lymphoid hypertrophy recurrent acute respiratory infections have been studied (base group). The ob tained data were compared similar results healthy children. It was shown that base group prevailed S. pyogenes, pneumoniae, mutans, P. vulgaris C. albicans. demonstarted the mainly induced by B. catharrhalis H. influenzae; — aureus influenzae. role polyclonal induction to...
Abstract. Several endogenic and synthetic peptides were investigated in order to reveal their antibacterial activity. The study of dose-depended effects activity the immunotropic peptide ZP-2, which is included GM-CSF active center, shown significant ZP-2 by action range rate bactericidal case low concentration. Combined application substance derived from supernatant CD34+CD45-cells enhances significantly actions each other. Probably, this effect connected with various mechanisms influence...
.
Development of angiogenesis depends on the functional state endothelial cells, as well balanced secretion cytokines, growth factors and chemokines by cells microenvironment. Macrophages represent an essential component microenvironment take part in formation blood vessels both due to production cytokines contact interactions with cells. VEGF is among most important that control at all its stages. Currently, role intercellular macrophages not described. The aim our study was investigate...
To explore the dynamics of admission patients for repeated compulsory treatment to a medical setting providing general and specialized psychiatric care.The in «Moscow Psychiatric clinical hospital No5» period 1991-2019 was analyzed based on records two groups patients: main group (n=1325) comparison (n=15 100).Over past 5 years, there is decrease admissions who have committed new socially dangerous act. This positive dynamic due compliance with principles continuity phasing between inpatient...