Known methods of treating chronic polypous rhinosinusitis do not have a significant effect on the progressive nature disease. Recently, anticytokine therapy has been developed and introduced. However, high cost drugs complexity their production make it necessary to search for other with similar mechanisms action. Such immunotropic can be recombinant IFNα-2b γ-D-glutamyl-L-tryptophan. The aim study is mechanism action evaluate effectiveness local application γ-D-glutamyl-L-tryptophan in...

Chronic rhinosinusitis (CRS) affects 5-12% of the world’s adult population. with nasal polyps (CRSwNP) accounts for 25-30% all cases CRS. CRSwNP-associated inflammatory process in mucosa and paranasal sinuses depends on characteristics local immunity, including expression a number cytokines. The aim this work was to investigate parameters immunity various clinical forms CRSwNP. In work, concentrations pro-inflammatory cytokines, i.e., interleukin-1β (IL-1β) IL-8, antimicrobial function...

The criteria for «odontogenic sinusitis» (OS) with the highest values of specificity and sensitivity were identified. An integral odontogenicity sinusitis index (OSI) was developed based on identified criteria. To measure criteria, a group 261 patients selected (113 women (43.29%), 148 men (56.70%), average age 36 years), consisting 150 known to have OS 111 who be without OS. As result data analysis, obtained all 13 Based values, combined into an divided «minor» «major». “large” assigned...

Objective. To evaluate melatonin (MT) excretion patterns in patients with polymorbid cardiovascular diseases (coronary artery disease, hypertension, metabolic syndrome), anxiety and depressive disorders, to determine the targets for therapeutic intervention this group of patients. Design methods . The study included 40 men (mean age — 37,11 ± 6,93 years) 10 healthy 37,5 4,95 years). We used complex psychological test methods, laboratory tests instrumental evaluation system....

Objective. To evaluate the lipid disorders and expression of fibroblast growth factor 21 in young middleaged men with multiple cardiovascular co-morbidities. Design methods. The study included 40 diseases (CVD) 10 healthy men. All participants underwent complex psychological tests, laboratory instrumental assessment. Fibroblast (FGF21) was measured by ELISA using BCM Diagnostics SK00145–01 kits (BCM Diagnostics, USA). Results. level FGF21 3‑fold higher patients CVD (269,02 ± 27,4 ng/l)...

Evaluate melatonin (MT) patterns excretion at multimorbid cardiovascular pathology (MCVP) (coronary artery disease (CAD), hypertension, metabolic syndrome (MS)) with non-psychot- ic mental disorders (NPMD) anxiety/ depressive type. Identify the effectiveness of visual-auditory ef- fects in treatment these pathologies. Design and methods: The study included 70 men (mean age 37,46±6,74) MCVP divided into 4 groups by simple random sampling, 20 healthy 38,3±6,73 g). Patients Group 1 (n = 22)...

Evaluate (FGF) 21 at multimorbid cardiovascular pathology (MCVP) (coronary artery disease (CAd), hypertension, metabolic syndrome (MS)) with non-psychotic mental disorders (NPMd) anxiety/ depressive type. Identify the effectiveness of visual-auditory effects in treatment these pathologies. design and methods: The study included 70 men (mean age 37,46±6,74) MCVP divided into 4 groups by simple random sampling, 20 healthy 38,3±6,73 g). Patients Group 1 (n = 22) received standard therapy CAd,...

Hyperostosis is a common consequence of chronic rhinosinusitis with nasal polyps (CRSwNP) and other rhinosinusitis, affecting mainly structures the ethmoid labyrinth, frontal maxillary sinuses. These neo-bones are found in advanced stages causes exacerbation because ostia outflow blockage. Frequent relapses disease due to hyperostosis restenosis, represent problem treatment sinusitis. We report our cases experience about sinusitis frontoethmoidal area hyperostosis, treated by modified...

Long-term persistence of inflammation is the main factor pathogenesis in chronic polypous rhinosinusitis (CRSwNP). Prospectives current clinical otorhinolaryngology include modification drugs containing topical glucocorticosteroids order to increase local bioavailability, reduce concentration glucocorticosteroids, and alleviate inflammatory response. The aim our work was evaluate effect urea, magnesium sulfate, mannitol on concentrations mometasone furoate IL-5 tissue patients with CRSwNP....

Objective: Identify the diagnostic signs for chronic rhinosinusitis with nasal polyps (CRSwNP & resistant forms) multimorbid cardiovascular pathology (MCVP) (coronary artery disease (CAd), hypertension, metabolic syndrome (MS). effectiveness of photodynamic therapy in CRSwNP treatment. Design and methods: The study included 75 patients (mean age 35,8±7,93, 39,2% - female,60,8% male) MCVP divided into 3 groups by simple random sampling. Patients group 1 (n = 27) received standard CRSwNP,...

Objective: To study the activity of apoptosis and premature aging in individuals middle age with polymorbidity cardiovascular disease non-psychotic mental disorders.Design methods: The included 78 men MCVP 20 healthy men. used study: complex psychological test methods laboratory-instrumental evaluation system. definition p53 protein was performed by ELISA using kits BMS eBioscience BMS256 (BenderMedSys- tems, uSA). Results: n group patients (PTS) level 4,89 uI / ml control group, 0,93 ml. In...

Parietal edema/edematous syndrome, appearing in isolation the paranasal sinuses, is most common radiographic finding. However, transformation of syndrome into polypous tissue, relationship with formation clinical forms rhinosinusitis are poorly understood. Objective. To reveal edematous mucous membrane sinuses meteorological elements (humidity, temperature, precipitation, wind speed). Describe mechanism pathogenetic between increased water vapor pressure and sinuses. Materials methods. The...