A5001408402- Acute Ischemic Stroke Management
- Venous Thromboembolism Diagnosis and Management
- Cerebrovascular and Carotid Artery Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Stroke Rehabilitation and Recovery
- Peripheral Artery Disease Management
- Healthcare Systems and Practices
- Radiomics and Machine Learning in Medical Imaging
- Clinical practice guidelines implementation
- Medical Imaging and Analysis
- Medical and Biological Sciences
- Air Quality and Health Impacts
- Advanced X-ray and CT Imaging
- Artificial Intelligence in Healthcare and Education
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Cardiac, Anesthesia and Surgical Outcomes
- Mental Health Research Topics
- Occupational exposure and asthma
- Dementia and Cognitive Impairment Research
- Cannabis and Cannabinoid Research
- Physical Activity and Health
- Heavy Metal Exposure and Toxicity
- Health, Environment, Cognitive Aging
- Frailty in Older Adults
- Impulse Buying and Technology Impacts
Southern University Law Center
2023
University of Calgary
1984-2022
University of Basel
2022
Health Net
2022
University Hospital of Basel
2022
Western Research Institute
2022
University Health Network
2022
Toronto Western Hospital
2022
University of Toronto
2022
University of New Mexico
2021
<h3>BACKGROUND AND PURPOSE:</h3> Thrombus characteristics identified on non-contrast CT (NCCT) are potentially associated with recanalization intravenous (IV) alteplase in patients acute ischemic stroke (AIS). Our aim was to determine the best radiomics-based features of thrombus NCCT and angiography IV AIS proximal intracranial thrombi. <h3>MATERIALS METHODS:</h3> With a nested case-control design, 67 ICA/M1 MCA segment treated were included this analysis. Three hundred twenty-six radiomics...
Background and Purpose— Little is known about the real-life factors that clinicians use in selection of patients would receive endovascular treatment (EVT) real world. We sought to determine patient, practitioner, health system associated with therapeutic decisions around treatment. Methods— conducted a multinational cross-sectional web-based study comprising 607 interventionalists from 38 countries who are directly involved acute stroke care. Participants were randomly allocated 10 pool 22...
Small iatrogenic brain infarcts are often seen on diffusion-weighted MRI (DWI) following surgical or endovascular procedures, but there few data their clinical effects. We examined the association of with outcomes in ENACT (Evaluating Neuroprotection Aneurysm Coiling Therapy) randomized controlled trial nerinetide patients undergoing repair intracranial aneurysms.In this post hoc analysis, we used multivariable models to evaluate presence and number DWI neurologic impairment (NIH Stroke...
We know without doubt that ‘time is brain’. How do we this? It a combination of data, logic, biological plausibility, and experience. Now endovascular treatment the standard care,1–5 have an obligation to focus on process improvement maximize patient benefit. As go down pathway improving these processes, it important understand idea bottlenecks. What are bottlenecks? In any complex process, not all parts flow-limiting, especially when one considers parallel processing. For instance,...
The Southwestern United States has a legacy of industrial mining due to the presence rich mineral ore deposits. relationship between environmental inhaled particulate matter (PM) exposures and neurological outcomes within an autoimmune context is understudied. aim this study was compare two regionally-relevant dusts from high-priority abandoned mine-sites, Claim 28 PM, Blue Gap Tachee, AZ St. Anthony mine Pueblo Laguna, NM expose autoimmune-prone mice (NZBWF1/J). Mice were randomly assigned...
Background and purpose Ischemic stroke patients must be transferred to comprehensive centers for endovascular treatment, but this transfer can interpreted post hoc as "futile" if do not ultimately undergo the procedure or have a poor outcome. We posit that decisions instead evaluated in terms of appropriateness at time decision-making. Methods propose classification schema Appropriateness Transfer Endovascular Thrombectomy based on patient, logistic, center characteristics. Results The...
Background and Purpose- The American Heart Association the Stroke guidelines for early management of patients with ischemic stroke offer guidance to physicians involved in acute care clarify endovascular treatment indications. purpose this study was assess concordance physicians' decision-making current using a survey-approach explore how absence guideline recommendations is approached. Methods- In an international cross-sectional survey (UNMASK-EVT), were randomly assigned 10 22 case...
Background and Purpose— The mobile stroke unit (MSU) brings imaging thrombolysis to patients in the field. MSU has potential decrease time from onset thrombolysis; however, this depends on location of patient, MSU, hospital. will only be able treat a small subset it is dispatched to. Using conditional probability modeling, we evaluate which scenarios exhibits clear benefit over direct-to-mothership method. Methods— Previously published models for drip-and-ship versus mothership transport...
ABSTRACT: Objective: Decisions to treat large-vessel occlusion with endovascular therapy (EVT) or intravenous alteplase depend on how physicians weigh benefits against risks when considering patients’ comorbidities. We explored EVT/alteplase decision-making by stroke experts in the setting of comorbidity/disability. Methods: In an international multi-disciplinary survey, chose treatment approaches under current resources and assumed ideal conditions for 10 22 randomly assigned case...
<h3>SUMMARY:</h3> The concept of Nash equilibrium, developed by John Forbes Jr, states that an equilibrium in noncooperative games is reached when each player takes the best action for himself or herself, taking into account actions other players. We apply this to provision endovascular thrombectomy treatment acute ischemic stroke and suggest collaboration among hospitals a health care jurisdiction could result practices such as shared call pools neurointervention teams, leading better...
The decision to proceed with endovascular thrombectomy should ideally be made independent of inconvenience factors, such as daytime. We assessed the influence patient presentation time on therapy making under current local resources and assumed ideal conditions in acute ischemic stroke level 2B evidence for treatment. In an international cross sectional survey, 607 physicians from 38 countries were asked give their treatment decisions 10 out 22 randomly assigned case scenarios. Eleven...
The hyperdense sign is a marker of thrombus in non-contrast computed tomography (NCCT) datasets. aim this work was to determine optimal Hounsfield unit (HU) thresholds for segmentation thin-slice CT and use these generate 3D models. Patients with baseline NCCT (≤2.5 mm) MCA-M1 occlusions were included. CTA registered NCCT, three regions interest (ROIs) placed the including: thrombus, contralateral brain tissue, patent artery. Optimal HU differentiating from non-thrombus tissue voxels...
ISEE-367 Introduction: During and after the Gulf War in 1991, burning of more than 700 oil wells caused a severe air pollution episode Kuwait neighboring countries. The Kuwaiti civilian population experienced heavy exposures to fine particles over period about 9 months following fires. To characterize exposure likely mortality risks from fires, we conducted detailed atmospheric modeling, location survey, formal elicitation expert judgment on particulate matter mortality-response. Methods:...
Differences in the treatment practice of female and male physicians have been shown several medical subspecialties. It is currently not known whether this also applies to endovascular stroke treatment. The purpose study was explore there are differences decisions made by neurointerventionalists.In an international survey, neurointerventionalists were randomly assigned 10 case scenarios asked how they would treat patient: (A) assuming no external constraints (B) given their local working...
<h3>BACKGROUND AND PURPOSE:</h3> With increasing use of endovascular therapy, physicians' attitudes toward intravenous alteplase in therapy–eligible patients may be changing. We explored current treatment practices physicians therapy– and alteplase-eligible with acute stroke using prespecified case scenarios compared how their local differ an assumed ideal environment. <h3>MATERIALS METHODS:</h3> In international multidisciplinary survey, 607 involved care were randomly assigned 10 22...