A5060570086- Bipolar Disorder and Treatment
- Schizophrenia research and treatment
- Adolescent and Pediatric Healthcare
- Pharmacological Effects and Toxicity Studies
- Epilepsy research and treatment
- Medication Adherence and Compliance
- Mental Health Treatment and Access
- Diabetes Management and Education
- Electroconvulsive Therapy Studies
- Attention Deficit Hyperactivity Disorder
- Family Caregiving in Mental Illness
- Child and Adolescent Psychosocial and Emotional Development
- Maternal Mental Health During Pregnancy and Postpartum
- Chronic Disease Management Strategies
- Diabetes Management and Research
- Health Systems, Economic Evaluations, Quality of Life
- Obsessive-Compulsive Spectrum Disorders
- Mental Health and Patient Involvement
- Family Support in Illness
- Complementary and Alternative Medicine Studies
- Primary Care and Health Outcomes
- Biomedical Text Mining and Ontologies
- Medicinal Plant Extracts Effects
- Perfectionism, Procrastination, Anxiety Studies
- Stuttering Research and Treatment
Case Western Reserve University
2014-2023
University Hospitals Cleveland Medical Center
2013-2023
Icahn School of Medicine at Mount Sinai
2023
Washington University in St. Louis
2023
University of Pittsburgh
2009-2023
National Institute of Mental Health
2023
University School
2009-2022
University Hospitals of Cleveland
2013-2021
The Centers
2021
The University of Texas Health Science Center at San Antonio
2021
Clinicians treating older patients with bipolar disorder mood stabilizers need evidence from age-specific randomized controlled trials. The authors describe findings a first such study of late-life mania.The compared the tolerability and efficacy lithium carbonate divalproex in 224 inpatients outpatients age 60 or I who presented manic, hypomanic, mixed episode. Participants were randomly assigned, under double-blind conditions, to treatment (target serum concentration, 0.80-0.99 mEq/L)...
Summary Objective Despite advances in care, many people with epilepsy have negative health events ( NHE s) such as accidents, emergency department visits, and poor quality of life. “ S elf‐ ma nagement fo r wi t h a history events” SMART ) is novel group format self‐management intervention. A community participatory approach informed the refinement , which was then tested 6‐month randomized controlled trial (n = 60) versus waitlist control WL n 60). Methods Participants were adults aged ≥18...
A 60-week randomized controlled trial assessed the effects of targeted training in illness management (TTIM) versus treatment as usual among 200 individuals with serious mental and diabetes mellitus.The study used Clinical Global Impression (CGI), Montgomery-Asberg Depression Rating Scale (MADRS), Brief Psychiatric (BPRS) to assess psychiatric symptoms; Assessment Functioning (GAF) Sheehan Disability (SDS) functioning; 36-Item Short-Form Health Survey (SF-36) general health, serum...
Article AbstractObjective: Bipolar disorder in older adult populations has gained increasing attention due to the growing proportion of elderly United States and worldwide. A continuing unmet need is identification agents that are generally well-tolerated effective later life bipolar disorder. Aripiprazole an atypical antipsychotic compound approved by U.S. Food Drug Administration for treatment mania long-term This study open-label, prospective trial aripiprazole therapy 20 patients with...
Sajatovic M, Gildengers A, Al Jurdi RK, Gyulai L, Cassidy KA, Greenberg RL, Bruce ML, Mulsant BH, Ten Have T, Young RC. Multisite, open-label, prospective trial of lamotrigine for geriatric bipolar depression: a preliminary report.Bipolar Disord 2011: 13: 294–302. © 2011 The Authors.Journal compilation John Wiley & Sons A/S. Aims: This is multisite, 12-week, open-label augmentation in 57 older adults (≥ 60 years; mean ± SD age = 66.5 6.7 years) with either type I or II depression. Methods:...
Article AbstractBackground: Treatment nonadherence in people with schizophrenia is associated relapse and homelessness. Building on the usefulness of long-acting medication our work psychosocial interventions to enhance adherence, we conducted a prospective uncontrolled trial customized adherence enhancement (CAE) plus injectable antipsychotic (LAI) using haloperidol decanoate 30 homeless or recently individuals DSM-IV-defined schizoaffective disorder.Method: Participants received monthly...
This randomized controlled study of 164 outpatients with bipolar disorder in a community mental health center who received standardized psychoeducation (Life Goals Program [LGP]) or treatment as usual sought to determine whether there were differences between the groups medication adherence attitudes and behaviors.Patients randomly assigned (N=80) plus LGP (N=84) assessed at baseline three-, six-, 12-month follow-up. Primary outcomes change score from on Drug Attitude Inventory (DAI)...
Sajatovic M, Levin J, Tatsuoka C, Micula‐Gondek W, Fuentes‐Casiano E, Bialko CS, Cassidy KA. Six‐month outcomes of customized adherence enhancement (CAE) therapy in bipolar disorder. Bipolar Disord 2012: 14: 291–300. © 2012 The Authors. Journal compilation John Wiley & Sons A/S. Background: There are few psychosocial interventions specifically focused on improved treatment people with disorder (BD). Customized is a needs‐based, manualized approach intended to improve medication...
In spite of growing numbers older people, there are few treatment studies on late-life bipolar disorder (BD). This was a 12-week prospective, open-label trial to assess efficacy and tolerability adjunct asenapine in non-demented adults (≥ 60 years) with sub-optimal previous response BD treatments.Asenapine initiated at 5 mg/day titrated as tolerated. Effects global psychopathology were measured Clinical Global Impression, version (CGI-BP), the Brief Psychiatric Rating Scale (BPRS). Mood...
Objectives This analysis of screening and baseline data from an ongoing trial examined self‐report versus automated adherence monitoring assessed the relationship between bipolar disorder (BD) symptoms in 104 poorly adherent individuals. Methods Adherence was measured with Tablets Routine Questionnaire (TRQ) Medication Event Monitoring System (MEMS). Symptoms were Montgomery–Åsberg Depression Rating Scale (MADRS), Young Mania (YMRS), Brief Psychiatric (BPRS). Results The mean age sample 46.3...
Medication nonadherence occurs in 20-60% of persons with bipolar disorder (BD) and is associated serious negative outcomes, including relapse, hospitalization, incarceration, suicide high healthcare costs. Various strategies have been developed to measure adherence BD. This descriptive paper summarizes challenges workable using electronic medication monitoring a randomized clinical trial (RCT) patients BD.Descriptive data from 57 nonadherent individuals BD enrolled prospective RCT evaluating...
Objective While previous work has demonstrated elevation of both comorbid anxiety disorders and diabetes mellitus type II in individuals with serious mental illness, little is known regarding the impact on outcomes illness populations. We analyzed baseline data from patients to examine relationships between anxiety, glucose control as measured by hemoglobin A1c score, overall burden. Methods Using an ongoing prospective treatment study involving 157 II, we compared without a disorder levels...
Treatment nonadherence is a leading cause of poor outcomes among populations with bipolar disorder (BD) and related to subjective experience illness treatment. This study examined gender differences in the treatment for those BD, specifically regards adherence. cross-sectional analysis pooled data from 3 BD studies. A semistructured qualitative instrument, Subjective Experience Medication Interview, elicited information on adherence between men women. Men women comparable levels stigma they...
Abstract Background By 2030, over 50% of individuals living with bipolar disorder (BD) are expected to be aged ≥50 years. However, older age (OABD) remains understudied. There limited large‐scale prospectively collected data organized in key dimensions capable addressing several fundamental questions about BD affecting this subgroup patients. Methods We developed initial recommendations for the essential OABD collection, based on (1) a systematic review measures used studies, (2) Delphi...
Objective: A three-month prospective trial of a psychosocial intervention—customized adherence enhancement (CAE)—was conducted with 43 medication-nonadherent individuals bipolar disorder. Methods: CAE modules were administered as indicated by screen that identifies reasons for nonadherence. The primary outcome was change in to mood-stabilizing medications measured the Tablet Routines Questionnaire and pill counts. Secondary outcomes included symptoms, Hamilton Rating Scale Depression...
Objective Serious mental illness and type II diabetes mellitus have a high comorbidity, both higher prevalence of anxiety disorders compared to the general population. Targeted Training in Illness Management is group-based self-management training approach which targets serious concurrently. This analysis examines data from randomized controlled trial intervention examine impact comorbid on baseline psychiatric symptomatology diabetic control, longitudinal treatment outcomes. Methods We...
Objective: This study evaluated the feasibility, acceptability, and preliminary efficacy of psychoeducation plus an automated text messaging intervention (Individualized Texting for Adherence Building–Cardiovascular [iTAB-CV]) to improve adherence antihypertensives bipolar disorder medication. Methods: After a program, iTAB-CV was administered 2 months. In month 1, participants received one educational-motivational mood rating daily. 2, medication reminders were added. Results: The sample...
To assess depressive symptom outcomes in a pooled sample of epilepsy self-management randomized controlled trials (RCTs) from the Managing Epilepsy Well (MEW) Network integrated research database (MEW DB).Five prospective RCTs involving 453 adults with compared intervention (n = 232) versus treatment as usual or wait-list control 221). Depression was assessed nine-item Patient Health Questionnaire. Other variables included age, gender, race, ethnicity, education, income, marital status,...