A5070353529- Osteoarthritis Treatment and Mechanisms
- Trace Elements in Health
- Total Knee Arthroplasty Outcomes
- Atherosclerosis and Cardiovascular Diseases
- Inflammatory mediators and NSAID effects
- Systemic Lupus Erythematosus Research
- Heavy Metal Exposure and Toxicity
- Cell Adhesion Molecules Research
- Bone health and treatments
- Rheumatoid Arthritis Research and Therapies
- Protease and Inhibitor Mechanisms
- COVID-19 Clinical Research Studies
- Tendon Structure and Treatment
- Systemic Sclerosis and Related Diseases
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Iron Metabolism and Disorders
- Proteoglycans and glycosaminoglycans research
- Advanced Glycation End Products research
- SARS-CoV-2 and COVID-19 Research
- Vasculitis and related conditions
- Long-Term Effects of COVID-19
- Medical Imaging Techniques and Applications
- Connective tissue disorders research
- Metalloenzymes and iron-sulfur proteins
- Psoriasis: Treatment and Pathogenesis
Hospital Del Mar
2015-2025
Hospital del Mar Research Institute
2015-2024
Municipal Institute for Medical Research
2013-2024
MemorialCare Health System
2021
Parc de Salut
2018
Center for Rheumatology
2018
Universitat Autònoma de Barcelona
2010
Universitat de Barcelona
2004-2009
Institut de Biomedicina de la Universitat de Barcelona
2009
We conducted a large-scale genetic analysis on giant cell arteritis (GCA), polygenic immune-mediated vasculitis. A case-control cohort, comprising 1,651 case subjects with GCA and 15,306 unrelated control from six different countries of European ancestry, was genotyped by the Immunochip array. also imputed HLA data previously validated imputation method to perform more comprehensive this genomic region. The strongest association signals were observed in region, rs477515 representing highest...
Although several heavy metal toxins are delivered to the kidney on carrier protein metallothionein (MT), uncertainty as how MT enters proximal tubular cells limits treatment strategies. Prompted by reports that MT-I interferes with renal uptake of megalin ligand beta(2)-microglobulin in conscious rats, we tested hypothesis binds and mediates its uptake. Three lines evidence suggest binding is critical MT-bound metals. First, megalin, but not cubilin, direct surface plasmon resonance studies....
Aging | doi:10.18632/aging.104117. Josep Blanch-Rubió, Natalia Soldevila-Domenech, Laura Tío, Jone Llorente-Onaindia, Manuel Ciria-Recasens, Luciano Polino, Alba Gurt, Rafael de la Torre, Maldonado, Jordi Monfort, the Covidmar Study Group
A sulfide surprise: The analysis of ZnII–, CdII–, and CuI–MT recombinant preparations metallothioneins (MTs) from many organisms provides clear evidence that ions are present in nearly all their physiologically stable ZnII–MT CdII–MT complexes (see picture), but none the species. features MT good correlation with those reported for plant yeast ZnII–or CdII–γ-glutamyl peptides. Supporting information this article is available on WWW under...
This paper reports on the characterization of metal binding abilities mammalian MT4 and their comparison with those well known MT1. Heterologous Escherichia coli expression in cultures supplemented zinc, cadmium, or copper was achieved for its separate αMT4 βMT4 domains as MT1 αMT1 domain cadmium-enriched medium. The vivo conformed complexes vitro substituted zinc/cadmium zinc/copper aggregates were characterized. Biosynthesis Cd(II)-supplemented medium revealed that these peptides failed to...
Knee osteoarthritis (KOA) has a complex, multifactorial nature with well-established risk factors which may influence treatment decisions. Here we want to identify distinctive characteristics between patients receiving conservative versus total knee replacement (TKR), analyzing both patient-specific and knee-specific features. This case-control study compared assigned TKR management, examining subjects aged 60-75 years radiographically confirmed KOA (Kellgren-Lawrence grades 2-3), all...
Advanced glycation end-products (AGEs) may play a relevant role as inducers in the chronic inflammatory pathway present immune-mediated diseases, such systemic lupus erythematosus (SLE). AGEs concentrations have been associated, with discrepant results to date, some parameters disease activity or accrual damage, suggesting their potential usefulness biomarkers of disease. Our objectives are confirm differences levels measured by cutaneous autofluorescence between SLE patients and healthy...
Abstract Brain injury and neuroinflammation are pathophysiologic contributors to acute chronic neurologic disorders, which progressive diseases not fully understood. Mammalian metallothioneins I II (MT‐I&II) have significant neuroprotective functions, but the precise mechanisms underlying these effects still unknown. To gain insight in this regard, we evaluated whether a distant, most likely single‐domain MT ( Drosophila MTN) functions similarly mammalian MT‐I&II (recombinant mouse...
Partial meniscectomy is one of the most common surgical strategy for a meniscal injury, but sometimes, patients complain knee pain due to an overload in ablated compartment. In these cases, implantation tissue engineering scaffold could be indicated. Currently, two commercial scaffolds, based on collagen or polycaprolactone-polyurethane (PCL-PU), are available meniscus scaffolding. short term follow-up assessments, both showed clinical improvement and formation. However, long-term studies...
Abstract In osteoarthritis (OA), chondrocyte metabolism dysregulation increases relative catabolic activity, which leads to cartilage degradation. To enable the semiquantitative interpretation of intricate mechanisms OA progression, we propose a network-based model at level that incorporates complex ways in inflammatory factors affect structural protein and protease expression nociceptive signals. Understanding such interactions will leverage identification new potential therapeutic targets...
Chicken metallothionein (ckMT) is the paradigm for study of metallothioneins (MTs) in Aves class vertebrates. Available literature data depict ckMT as a one‐copy gene, encoding an MT protein highly similar to mammalian MT1. In contrast, system mammals consists four‐member family exhibiting functional differentiation. This scenario prompted us analyse apparently distinct evolutionary patterns followed by MTs birds and mammals, at both structural levels. Thus, this work, metal binding...
Introduction: 
 Advanced glycation end-products (AGEs) may play a relevant role as inducers in the chronic inflammatory pathway present immune-mediated diseases, such systemic lupus erythematosus (SLE). AGEs concentrations have been associated, with discrepant results to date, some parameters disease activity or accrual damage, suggesting their potential usefulness biomarkers of disease.
 Objectives: To confirm differences levels measured by cutaneous autofluorescence between SLE...
It has been postulated that advanced glycation end products (AGEs) and their soluble receptor (sRAGE) may play a relevant role as inducers in the chronic inflammatory pathway various conditions, among them, immune-mediated diseases such systemic lupus erythematosus (SLE). However, previous studies show conflicting results about association with SLE characteristics usefulness disease biomarkers. We aimed to study of specific serum AGEs (pentosidine, Nξ-(carboxymethyl)lysine (CML),...
Objective: The objective of this study was to investigate the relationship between choice clinical treatment, gait functionality, and kinetics in patients with comparable knee osteoarthritis. Design: This an observational case-control study. Setting: conducted a university biomechanics laboratory. Participants: Knee osteoarthritis were stratified into following groups: treatment (conservative/total replacement (TKR) planned), sex (male/female), age (60–67/68–75), body mass index (BMI)...