A5014360452- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Retinal Diseases and Treatments
- Ophthalmology and Eye Disorders
- Ocular Surface and Contact Lens
- Retinal Imaging and Analysis
- Cerebral Venous Sinus Thrombosis
- Intraocular Surgery and Lenses
- Neurological Disorders and Treatments
- Retinal Development and Disorders
- Optical Coherence Tomography Applications
- Ocular Oncology and Treatments
- Proteoglycans and glycosaminoglycans research
- Ophthalmology and Visual Impairment Studies
- Connexins and lens biology
- Neurological Disease Mechanisms and Treatments
- Sympathectomy and Hyperhidrosis Treatments
- Bacterial Identification and Susceptibility Testing
- Cancer-related Molecular Pathways
- Facial Rejuvenation and Surgery Techniques
- Dermatologic Treatments and Research
- Urticaria and Related Conditions
- Medicinal plant effects and applications
- Traumatic Ocular and Foreign Body Injuries
- NF-κB Signaling Pathways
The University of Tokyo
2015-2025
University of Tokyo Hospital
2018-2024
Yotsuya Medical Cube
2022-2024
Ophthalmology Associates (United States)
2024
Tokyo Metropolitan Geriatric Hospital
2012-2018
Miyata Eye Hospital
2015
To investigate the effects of prostaglandin (PG) analogues on adipogenesis so as to clarify mechanism a side effect topical PG analogues: deepening upper eyelid sulcus (DUES), which has been reported in this decade.The 3T3-L1 preadipocytes were treated promote differentiation into mature adipocytes. During early and late stages (days 0, 2, 7), 1 1000 nM latanoprost acid (LAT-A), travoprost (TRA-A), tafluprost (TAF-A), bimatoprost (BIM), (BIM-A), unoprostone (UNO), or F2a (PGF2α) was applied...
To investigate the prognostic factors responsible for progression of visual field defects (VFDs) in patients with normal-tension glaucoma (NTG) treated topical antiglaucoma medications.A total 92 eyes NTG only medications ≥ 5 years were retrospectively analyzed. identify subfield-based factors, central 30-degree (Humphrey Field Analyzer) was divided into 6 subfields: upper and lower arcuate, paracentral, cecocentral subfields. Factors related to (age, refraction, mean intraocular pressure...
Aims To apply a deep learning model for automatic localisation of the scleral spur (SS) in anterior segment optical coherence tomography (AS-OCT) images and compare reproducibility chamber angle (ACA) width between located SS (DLLSS) manually plotted (MPSS). Methods In this multicentre, cross-sectional study, test dataset comprising 5166 AS-OCT from 287 eyes (116 healthy with open angles 171 primary angle-closure disease (PACD)) subjects were recruited four ophthalmology clinics. Each eye...
To evaluate the cross-sectional configurations of peripapillary atrophy (PPA)-alpha and -beta in ophthalmologically normal subjects using spectral domain-optical coherence tomography (SD-OCT).One hundred twenty had a complete ophthalmic examination including axial length measurement, standard automated perimetry, fundus imaging with photography, SD-OCT (3D OCT-1000; Topcon Inc., Tokyo, Japan). PPA-alpha were identified color photographs optic disc. Cross-sectional B-mode images retina...
Purpose.: We investigated the correlation between 24-hour IOP in habitual (sitting during day and supine night) position (H24h-IOP) after a postural-change test (PCT-IOP) water-drinking (WDT-IOP). also ocular systemic factors related with them patients normal tension glaucoma (NTG). Methods.: Japanese NTG underwent H24h-IOP, PCT-IOP, WDT-IOP measurements period. Correlations among WDT-IOP, contributing ocular/systemic were using regression analysis. Results.: There 33 included. Peak H24h-IOP...
Abstract This study investigated the effects of omidenepag (OMD), a novel selective EP2 receptor agonist, on human trabecular meshwork (HTM) cells, monkey Schlemm’s canal endothelial (SCE) and porcine ciliary muscle (CM) to clarify mechanism intraocular pressure (IOP) reduction involving conventional outflow pathway. In HTM SCE OMD transforming growth factor-β2 (TGF-β2)-induced changes were examined. The expression actin cytoskeleton extracellular matrix (ECM) proteins, myosin light chain...
Glutamate excitotoxicity is involved in retinal ganglion cell (RGC) death various degenerative diseases, including ischemia-reperfusion injury and glaucoma. Excitotoxic RGC caused by both direct damage to RGCs indirect through neuroinflammation of glial cells. Omidenepag (OMD), a novel E prostanoid receptor 2 (EP2) agonist, recently approved intraocular pressure-lowering drug. The second messenger EP2 cyclic adenosine monophosphate (cAMP), which activates protein kinase A (PKA) exchange...
Trabecular meshwork constitutes the conventional outflow pathway and controls intraocular pressure by regulating aqueous outflow. Mechanical stimulation has been studied as one of triggers to regulate in trabecular meshwork, but it is not well understood. We investigated that how transient receptor potential cation channel subfamily V member 4 (TRPV4) functions human cells (HTMC) affects (IOP). HTMC were treated with TRPV4 siRNA, followed incubation for 24 hours. confirmed suppression mRNA...
Visual acuity (VA) outcomes after phacoemulsification cataract surgery in the very elderly (≥90 years) compared to those younger patients remain unclear till date.We retrospectively investigated 138 (group 1) and 152 2) eyes aged ≥90 < 80 years, respectively, with senile cataracts who underwent intraocular lens implantation between 2014 2016. Four highly experienced ophthalmic surgeons performed procedures. Intra- post-operative complications were two groups. To investigate effectiveness of...
The purpose of this study was to evaluate the structure function relationship circumpapillary vessel density (cpVD) with visual field sensitivity (VFS) and compare its characteristics retinal nerve fiber layer thickness (cpRNFLT) in early glaucomatous (EG) normal eyes without high myopia (HM).Seventy-five EG (mean deviation > -6 dB) 7 HM (axial length [AL] >26.5 mm) 111 11 were enrolled retrospective cross-sectional study. All patients underwent optical coherence tomography (OCT) OCT...
Purpose: It is reported that nonsteroidal anti-inflammatory drug (NSAID) ophthalmic solution affected the therapeutic efficacy of prostaglandin (PG) analog by inhibiting endogenous PG production. However, whether NSAID interferes with its conjunctival hyperemia unknown. We investigated effect on hyperemia. Materials and Methods: This was a prospective, randomized, double-blind, placebo-controlled 1-month trial. Benzalkonium chloride-free travoprost 0.004% used as administered once daily...
The purpose of the study was to evaluate 12-month surgical outcome and prognostic factors stand-alone ab interno trabeculotomy. changes in intraocular pressure (IOP) medication score success rate surgery were analyzed. Thirty-four eyes 29 patients with primary open-angle glaucoma (POAG; n = 16) or pseudoexfoliation (PEG; 18) a follow-up period included study. decreases IOP from baseline all-time-point statistically significant ( P < 0.001). rates 97.1%, 76.5%, 44.0% at 3 months (90 days),...