A5016312625- CRISPR and Genetic Engineering
- Pluripotent Stem Cells Research
- Genomics and Chromatin Dynamics
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- T-cell and B-cell Immunology
University of Copenhagen
2025
Novo Nordisk Foundation
2025
Technical University of Munich
2019
T cell maintenance in chronic infection and cancer follows a hierarchical order. Short-lived effector CD8 cells are constitutively replaced from proliferation-competent Tcf1-expressing progenitor population. This occurs spontaneously at low levels increases magnitude upon blocking PD-1 signaling. We explore how CD4 help controls transition survival of the progenitors their progeny by utilizing single-cell RNA sequencing. Unexpectedly, absence caused reductions numbers only among terminally...
Abstract Development and lineage choice are driven by interconnected transcriptional, epigenetic metabolic changes. Specific metabolites, such as α-ketoglutarate (αKG), function signalling molecules affecting the activity of chromatin-modifying enzymes. However, how metabolism coordinates cell-state changes, especially in human pre-implantation development, remains unclear. Here we uncover that inducing naive embryonic stem cells towards trophectoderm results considerable rewiring,...