A5077871794- biodegradable polymer synthesis and properties
- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- Advanced Polymer Synthesis and Characterization
- 3D Printing in Biomedical Research
- Biopolymer Synthesis and Applications
- Polymer Surface Interaction Studies
- Orthopaedic implants and arthroplasty
- Photopolymerization techniques and applications
- Additive Manufacturing and 3D Printing Technologies
- Synthesis and properties of polymers
- Silicone and Siloxane Chemistry
- Enzyme Catalysis and Immobilization
- Facial Trauma and Fracture Management
- Dental materials and restorations
- Injection Molding Process and Properties
- Polymer Foaming and Composites
- Polymer Science and PVC
- Graphene and Nanomaterials Applications
- Epoxy Resin Curing Processes
- Treatment of Major Depression
- Oral health in cancer treatment
- Carbon dioxide utilization in catalysis
- Tissue Engineering and Regenerative Medicine
- Canadian Identity and History
Aalto University
2011-2019
University of Helsinki
2002-2009
Three-dimensional printing (3DP) refers to a group of additive manufacturing techniques that can be utilized in tissue engineering applications. Fused deposition modeling (FDM) is 3DP method capable using common thermoplastic polymers. However, the scope materials applicable for FDM has not been fully recognized. The purpose this study was examine creation biodegradable porous scaffold structures different and determine compressive properties fibroblast cell response structures. To best our...
Copolymers of ε-CL/L-LA and ε-CL/DL-LA were allowed to age in a buffer solution pH 7 at 23 37°C. The effects time temperature on the rate hydrolysis examined by various techniques including weighing (water absorption weight loss), SEC (molecular polydispersity), DSC (thermal properties). For comparison, hydrolytic behavior PLLA, PDLLA, commercial PCL homopolymers was investigated same methods. measurements showed that molecular weights copolymers PLA started decrease during first week...
Conclusions: This study demonstrates proof of concept for controlled manufacturing methods that utilize novel tailored biopolymers (3D photocuring technology) or conventional bioresorbable polymers (fused deposition modeling, FDM) macroscopic and microscopic geometry control. The manufactured scaffolds could be suitable tissue engineering research. Objectives: To design trachea scaffold prototypes purposes, to fabricate them by additive manufacturing. Methods: A commercial 3D model CT scans...
A novel photo-curable polyurethane resin for stereolithography has been demonstrated herein.
Copolymers of ε-CL/L-LA and ε-CL/DL-LA for comparison homopolymers PLLA, PDLLA, PCL were allowed to age in a buffer solution pH 7 at 23 37°C studied the changes mechanical properties taking place as function hydrolysis time. Tensile modulus measurements showed copolymers retain their much longer than did PLA homopolymers. The became stiffer with hydrolysis, while elongation break decreased gradually. For amorphous P(CL60/L-LA40) copolymer, tensile yield stress values increased dramatically...
Abstract Crosslinking is a feasible way to prepare biodegradable polymers with potential in biomedical applications such as controlled release of active agents and tissue engineering. A synthesis route which functional telechelic aliphatic polyester oligomers are used precursors for the preparation crosslinked polyesters poly(ester anhydride)s described. Mechanical properties, degradation characteristics rate, bioactivity can be modified widely by controlling chemical composition...
Abstract Objectives To characterize biological response to subcutaneously implanted macroporous poly(ε‐caprolactone/D,L‐lactide)‐based scaffolds, and evaluate the effect of bioactive glass ( BAG ) filler osteogenic cells tissue ectopic bone formation. Material methods In first part this study, six different scaffold types were screened in a rat subcutaneous implantation model. The polymer scaffolds with 70/30 caprolactone/lactide ratio corresponding composites < 45 μm size chosen for...
Abstract Aliphatic polyesters, such as poly(lactic acids), need high molecular weight for acceptable mechanical properties. This can be achieved through ring-opening polymerization of lactides. The lactide route is, however, relatively complicated, and alternative routes are interest. In this paper we report the properties a polymer made by two-step process: first condensation lactic acid then an increase with diisocyanate. end product is thermoplastic poly(ester-urethane)....
Abstract Average scaffold pore sizes in the order of several hundred microns are generally required for efficient bone tissue ingrowth vivo , whereas culture large engineering constructs vitro can require bioreactor cultures to decrease diffusional constraints on cells. In this study, we prepared poly(ε‐caprolactone/ D,L ‐lactide)‐based scaffolds with continuous phase macroporosity using a novel CaCl 2 · 6H O porogen agent. Osteogenic differentiation and colonization rat marrow stromal cell...
Abstract This paper describes a straightforward and rapid on‐line characterization using high‐performance liquid chromatography/electrospray ionization tandem mass spectrometry (HPLC/ESI‐MS n ) of the enzymatic degradation products 2,2′‐bis(2‐oxazoline)‐linked poly‐ ε ‐caprolactone (PCL‐O). These new PCL‐O polymers are expected to be used in variety pharmaceutical biomedical applications since they degraded enzymatically by surface erosion. was polymerized three‐step reaction characterized 1...
Purpose . This study aimed to explore if initiation of biomimetic apatite nucleation can be used enhance osteoblast response biodegradable tissue regeneration composite membranes. Materials and Methods Bioactive thermoplastic composites consisting poly( ε -caprolactone/DL-lactide) bioactive glass (BAG) were prepared at different stages calcium phosphate deposition by immersion in simulated body fluid (SBF). The modulation the BAG dissolution osteogenic rat mesenchymal stem cells (MSCs)...
The purpose of this study was to evaluate bacterial adhesion and early colonization on a composite consisting bioactive glass (BAG) particles copolymer ε ‐caprolactone/D,L‐lactide. Materials were incubated with suspensions both type strains clinical isolates Streptococcus pneumoniae, Haemophilus influenzae , Pseudomonas aeruginosa for 30 minutes (adhesion) 4 hours (colonization). Clear differences exist in the microorganisms′ ability adhere experimental materials. However, presence BAG does...
A series of ceramic-polymer scaffolds were studied for bone tissue engineering applications. These applications require reactivity as well suitable scaffold properties and structure. Bioactive glass (BAG) sol-gel derived silicas chosen ceramic components the scaffolds, crosslinked poly(ε-caprolactone/D,L-lactide) copolymers with monomer ratios 90/10 70/30 used polymer matrices. Scaffolds prepared by photo-curing crosslinkable oligomers in presence component porosity producing salt. 60-80...