Swapnil Singh

ORCID: 0000-0003-1432-1318
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About
Contact & Profiles
Research Areas
  • RNA modifications and cancer
  • Sarcoma Diagnosis and Treatment
  • Cancer-related molecular mechanisms research
  • interferon and immune responses
  • Cytokine Signaling Pathways and Interactions
  • Ubiquitin and proteasome pathways
  • Cancer-related Molecular Pathways
  • Management of metastatic bone disease
  • Orthopaedic implants and arthroplasty
  • Total Knee Arthroplasty Outcomes
  • MicroRNA in disease regulation
  • Immune Cell Function and Interaction
  • Bone health and treatments
  • Orthopedic Infections and Treatments
  • Oral microbiology and periodontitis research
  • Medical Imaging and Analysis
  • Scientific and Engineering Research Topics
  • Pelvic and Acetabular Injuries
  • Cancer Diagnosis and Treatment
  • Dental Radiography and Imaging

Albert Einstein College of Medicine
2021-2025

Montefiore Medical Center
2021-2025

University of Alabama at Birmingham
2024

National University Health System
2022

The Bronx Defenders
2022

Peking University People's Hospital
2022

University Health System
2022

Peking University
2022

Gautam Buddha University
2022

Abstract Osteosarcoma(OS) is a highly aggressive bone cancer for which treatment has remained essentially unchanged decades. Although OS characterized by extensive genomic heterogeneity and instability, RB1 TP53 have been shown to be the most commonly inactivated tumor suppressors in OS. We previously generated mouse model with double knockout (DKO) of Rb1 Trp53 within cells osteoblastic lineage, largely recapitulates human nearly complete penetrance. SKP2 repression target pRb serves as...

10.1038/s41388-024-02942-4 article EN cc-by Oncogene 2024-02-14

Osteosarcoma is a highly aggressive malignancy for which treatment has remained essentially unchanged years. Our previous studies found that the F-box protein SKP2 overexpressed in osteosarcoma, acting as proto-oncogene; p27Kip1 (p27) an inhibitor of cyclin-dependent kinases and downstream substrate SKP2-mediated ubiquitination. Overexpression underexpression p27 are common characteristics cancer cells. The SCFSKP2 E3 ligase ubiquitinates Thr187-phosphorylated proteasome degradation, can be...

10.1111/nyas.14578 article EN Annals of the New York Academy of Sciences 2021-02-16

The pelvis is one of the most common locations for metastatic bone disease. While many publications that describe surgical treatments focus on periacetabular lesions (Enneking zone II), there a lack investigation into in non-periacetabular areas (zones I, III, and IV). We recently described minimally invasive percutaneous screw application zone-II with excellent results. In present study, we aimed to extend this approach other pelvic areas.Twenty-two consecutive patients painful cancer were...

10.2106/jbjs.21.00518 article EN Journal of Bone and Joint Surgery 2022-02-09

Osteosarcoma is an aggressive bone malignancy with a poor prognosis. One putative proto-oncogene in osteosarcoma SKP2, encoding substrate recognition factor of the SCF E3 ubiquitin ligase. We previously demonstrated that Skp2 knockout murine improved survival and delayed tumorigenesis. Here, we performed RNA sequencing (RNA-seq) on tumors from transgenic mouse model conditional Trp53 Rb1 knockouts osteoblast lineage ("DKO": Osx1-Cre;Rb1lox/lox;p53lox/lox) triple-knockout additional germline...

10.1158/1535-7163.mct-23-0173 article EN Molecular Cancer Therapeutics 2023-10-23

The effect of post-operative patella tilt on functional outcomes after total knee arthroplasty remains unclear. Our study aimed to analyze the relationship patellar with outcome scores arthroplasty.

10.1007/s43465-023-01077-0 article EN cc-by Indian Journal of Orthopaedics 2024-02-19

The percutaneous screw reconstruction technique, known as the "Tripod Technique," has demonstrated favorable clinical outcomes in management of metastatic periacetabular lesions, evidenced by our prior investigations and corroborated independent studies. Nevertheless, there is a steep learning curve handling this with possible complications such intraarticular placement.

10.3389/fbioe.2024.1404937 article EN cc-by Frontiers in Bioengineering and Biotechnology 2024-07-29

Abstract Objective: Osteosarcoma is a highly aggressive malignancy for which treatment has remained essentially unchanged years. Our previous studies found that the F-box protein SKP2 overexpressed in osteosarcoma, acting as proto-oncogene. p27Kip1 (p27) an inhibitor of cyclin-dependent kinases and downstream substrate SKP2. The present study focused on role SCF-SKP2-mediated ubiquitination degradation p27 osteosarcoma (OS) tumorigenesis. Methods: We generated genetically engineered mouse...

10.1158/1538-7445.am2021-2008 article EN Cancer Research 2021-07-01

<div>Abstract<p>Osteosarcoma is an aggressive bone malignancy with a poor prognosis. One putative proto-oncogene in osteosarcoma <i>SKP2</i>, encoding substrate recognition factor of the SCF E3 ubiquitin ligase. We previously demonstrated that <i>Skp2</i> knockout murine improved survival and delayed tumorigenesis. Here, we performed RNA sequencing (RNA-seq) on tumors from transgenic mouse model conditional <i>Trp53</i> <i>Rb1</i>...

10.1158/1535-7163.c.7054216.v1 preprint EN 2024-02-01

<div>Abstract<p>Osteosarcoma is an aggressive bone malignancy with a poor prognosis. One putative proto-oncogene in osteosarcoma <i>SKP2</i>, encoding substrate recognition factor of the SCF E3 ubiquitin ligase. We previously demonstrated that <i>Skp2</i> knockout murine improved survival and delayed tumorigenesis. Here, we performed RNA sequencing (RNA-seq) on tumors from transgenic mouse model conditional <i>Trp53</i> <i>Rb1</i>...

10.1158/1535-7163.c.7054216 preprint EN 2024-02-01
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