A5046776364- RNA modifications and cancer
- Sarcoma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- interferon and immune responses
- Cytokine Signaling Pathways and Interactions
- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- Management of metastatic bone disease
- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- MicroRNA in disease regulation
- Immune Cell Function and Interaction
- Bone health and treatments
- Orthopedic Infections and Treatments
- Oral microbiology and periodontitis research
- Medical Imaging and Analysis
- Scientific and Engineering Research Topics
- Pelvic and Acetabular Injuries
- Cancer Diagnosis and Treatment
- Dental Radiography and Imaging
Albert Einstein College of Medicine
2021-2025
Montefiore Medical Center
2021-2025
University of Alabama at Birmingham
2024
National University Health System
2022
The Bronx Defenders
2022
Peking University People's Hospital
2022
University Health System
2022
Peking University
2022
Gautam Buddha University
2022
Abstract Osteosarcoma(OS) is a highly aggressive bone cancer for which treatment has remained essentially unchanged decades. Although OS characterized by extensive genomic heterogeneity and instability, RB1 TP53 have been shown to be the most commonly inactivated tumor suppressors in OS. We previously generated mouse model with double knockout (DKO) of Rb1 Trp53 within cells osteoblastic lineage, largely recapitulates human nearly complete penetrance. SKP2 repression target pRb serves as...
Osteosarcoma is a highly aggressive malignancy for which treatment has remained essentially unchanged years. Our previous studies found that the F-box protein SKP2 overexpressed in osteosarcoma, acting as proto-oncogene; p27Kip1 (p27) an inhibitor of cyclin-dependent kinases and downstream substrate SKP2-mediated ubiquitination. Overexpression underexpression p27 are common characteristics cancer cells. The SCFSKP2 E3 ligase ubiquitinates Thr187-phosphorylated proteasome degradation, can be...
The pelvis is one of the most common locations for metastatic bone disease. While many publications that describe surgical treatments focus on periacetabular lesions (Enneking zone II), there a lack investigation into in non-periacetabular areas (zones I, III, and IV). We recently described minimally invasive percutaneous screw application zone-II with excellent results. In present study, we aimed to extend this approach other pelvic areas.Twenty-two consecutive patients painful cancer were...
Osteosarcoma is an aggressive bone malignancy with a poor prognosis. One putative proto-oncogene in osteosarcoma SKP2, encoding substrate recognition factor of the SCF E3 ubiquitin ligase. We previously demonstrated that Skp2 knockout murine improved survival and delayed tumorigenesis. Here, we performed RNA sequencing (RNA-seq) on tumors from transgenic mouse model conditional Trp53 Rb1 knockouts osteoblast lineage ("DKO": Osx1-Cre;Rb1lox/lox;p53lox/lox) triple-knockout additional germline...
The effect of post-operative patella tilt on functional outcomes after total knee arthroplasty remains unclear. Our study aimed to analyze the relationship patellar with outcome scores arthroplasty.
The percutaneous screw reconstruction technique, known as the "Tripod Technique," has demonstrated favorable clinical outcomes in management of metastatic periacetabular lesions, evidenced by our prior investigations and corroborated independent studies. Nevertheless, there is a steep learning curve handling this with possible complications such intraarticular placement.
Osteosarcoma (OS) is an aggressive bone malignancy with a poor prognosis. One putative proto-oncogene in OS
Abstract Objective: Osteosarcoma is a highly aggressive malignancy for which treatment has remained essentially unchanged years. Our previous studies found that the F-box protein SKP2 overexpressed in osteosarcoma, acting as proto-oncogene. p27Kip1 (p27) an inhibitor of cyclin-dependent kinases and downstream substrate SKP2. The present study focused on role SCF-SKP2-mediated ubiquitination degradation p27 osteosarcoma (OS) tumorigenesis. Methods: We generated genetically engineered mouse...
<p>Pan-cancer TCGA analysis of macrophage infiltration correlation with SKP2 and survival via TIMER2.0</p>
<p>Macrophage polarization marker derivation from reanalysis of MacSpectrum single-cell RNA-seq data.</p>
<p>Transcription factor and oncogene signature overrepresentation analysis in TKO vs DKO</p>
<div>Abstract<p>Osteosarcoma is an aggressive bone malignancy with a poor prognosis. One putative proto-oncogene in osteosarcoma <i>SKP2</i>, encoding substrate recognition factor of the SCF E3 ubiquitin ligase. We previously demonstrated that <i>Skp2</i> knockout murine improved survival and delayed tumorigenesis. Here, we performed RNA sequencing (RNA-seq) on tumors from transgenic mouse model conditional <i>Trp53</i> <i>Rb1</i>...
<p>SKP2 KO signature is associated with macrophages and improved survival in Kuijjer 2012 OS cohort</p>
<p>Gene set enrichment analysis (GSEA) indicates upregulation of interferon response and downregulation unfolded protein in TKO.</p>
<p>Pan-cancer TCGA analysis of macrophage infiltration correlation with SKP2 and survival via TIMER2.0</p>
<p>Osteoclast and osteoblast marker expression principal component analysis of TKO DKO samples.</p>
<p>Gene set overrepresentation analysis of genes significantly correlated with SKP2 in the NCI TARGET OS cohort</p>
<p>Osteoclast and osteoblast marker expression principal component analysis of TKO DKO samples.</p>
<p>Immunohistochemistry of endothelial marker Cd31</p>
<div>Abstract<p>Osteosarcoma is an aggressive bone malignancy with a poor prognosis. One putative proto-oncogene in osteosarcoma <i>SKP2</i>, encoding substrate recognition factor of the SCF E3 ubiquitin ligase. We previously demonstrated that <i>Skp2</i> knockout murine improved survival and delayed tumorigenesis. Here, we performed RNA sequencing (RNA-seq) on tumors from transgenic mouse model conditional <i>Trp53</i> <i>Rb1</i>...
<p>DESeq2 results and DESEq2 size-factor normalize counts for TKO vs DKO bulk RNAseq samples</p>
<p>Macrophage polarization marker derivation from reanalysis of MacSpectrum single-cell RNA-seq data.</p>
<p>Immunohistochemistry of endothelial marker Cd31</p>
<p>Gene set overrepresentation analysis of genes significantly correlated with SKP2 in the NCI TARGET OS cohort</p>