A5059863693- Sarcoma Diagnosis and Treatment
- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Orthopedic Surgery and Rehabilitation
- Cancer-related Molecular Pathways
- Bone fractures and treatments
- Foot and Ankle Surgery
- Ubiquitin and proteasome pathways
- Hip and Femur Fractures
- Pelvic and Acetabular Injuries
- Wound Healing and Treatments
- Musculoskeletal pain and rehabilitation
- Global Health Workforce Issues
- Parathyroid Disorders and Treatments
- Shoulder and Clavicle Injuries
- Cervical and Thoracic Myelopathy
- Musculoskeletal synovial abnormalities and treatments
- Elbow and Forearm Trauma Treatment
- Urologic and reproductive health conditions
- Tendon Structure and Treatment
- Medical Education and Admissions
- Spinal Hematomas and Complications
- Diversity and Career in Medicine
- Protein Degradation and Inhibitors
- Nerve Injury and Rehabilitation
Al-Balqa Applied University
2023-2024
Albert Einstein College of Medicine
2020-2024
Montefiore Medical Center
2020-2024
University of British Columbia
2023-2024
Copyright Licensing Agency
2023
University of Calgary
2022-2023
Montefiore Health System
2021
Hamad General Hospital
2017-2020
Hamad Medical Corporation
2017-2020
Ankara Spine Center
2020
Abstract Osteosarcoma(OS) is a highly aggressive bone cancer for which treatment has remained essentially unchanged decades. Although OS characterized by extensive genomic heterogeneity and instability, RB1 TP53 have been shown to be the most commonly inactivated tumor suppressors in OS. We previously generated mouse model with double knockout (DKO) of Rb1 Trp53 within cells osteoblastic lineage, largely recapitulates human nearly complete penetrance. SKP2 repression target pRb serves as...
Abstract Purpose The management of cervical facet dislocation injuries remains controversial. main purpose this investigation was to identify whether a surgeon’s geographic location or years in practice influences their preferred traumatic injuries. Methods A survey sent 272 AO Spine members across all regions and with variety experience. included clinical case scenarios asked responders select preferences among various diagnostic options. Results total 189 complete responses were received....
Osteosarcoma is a highly aggressive malignancy for which treatment has remained essentially unchanged years. Our previous studies found that the F-box protein SKP2 overexpressed in osteosarcoma, acting as proto-oncogene; p27Kip1 (p27) an inhibitor of cyclin-dependent kinases and downstream substrate SKP2-mediated ubiquitination. Overexpression underexpression p27 are common characteristics cancer cells. The SCFSKP2 E3 ligase ubiquitinates Thr187-phosphorylated proteasome degradation, can be...
Synovial sarcoma (SS) is an aggressive soft-tissue cancer with a poor prognosis and propensity for local recurrence distant metastasis. In this study, we investigated whether S phase kinase-associated protein (Skp2) plays oncogenic role in tumor initiation, progression, metastasis of SS. Our study revealed that Skp2 frequently overexpressed SS specimens SS18-SSX transgenic mouse tumors, as well correlated clinical stages. Next, identified genetic depletion reduced mesenchymal stemness...
We present two pediatric cases of nontraumatic myositis ossificans (MO), which initially mimicked infections, leading to unnecessary treatments. The first case involves an 11-year-old boy with acute left hip pain and swelling, misdiagnosed as a joint infection treated antibiotics before histology confirmed MO. second is two-year-old girl who presented limping restricted movement, suspected have septic arthritis. Following MRI clinical reassessment, her condition was diagnosed Both highlight...
Abstract Introduction Talus fractures are not uncommon and one of the serious in foot ankle. Peroneal tendon dislocation is commonly missed soft tissue injuries which may have significant impact on outcomes including persistent pain swelling. They been reported to be associated with calcaneum as well talus fractures. Aim To report incidence peroneal fracture significance fleck sign diagnosis dislocation. Methods We retrospectively reviewed 93 consecutive period between 1/1/2011 1/11/2018....
Abstract Objective: Osteosarcoma is a highly aggressive malignancy for which treatment has remained essentially unchanged years. Our previous studies found that the F-box protein SKP2 overexpressed in osteosarcoma, acting as proto-oncogene. p27Kip1 (p27) an inhibitor of cyclin-dependent kinases and downstream substrate SKP2. The present study focused on role SCF-SKP2-mediated ubiquitination degradation p27 osteosarcoma (OS) tumorigenesis. Methods: We generated genetically engineered mouse...
Phenomenon: Choosing a medical specialty is critical decision that significantly impacts students' future career. Understanding the factors influencing this decision-making process important for educators, policymakers, and healthcare providers to develop effective strategies support guide students in making informed decisions. Approach: We distributed an online self-administered questionnaire clinical-year (Years 4 6) interns from all faculties Jordan. The gathered demographic information,...
This case report presents a novel cause of rigid flatfoot caused by the entrapment Flexor Hallucis Longus (FHL) tendon within subtalar joint. A 19-year-old male with chronic right ankle and foot pain diagnosed deformity. MRI identified FHL entrapped joint, condition to our knowledge never previously reported. highlights importance thorough clinical evaluation advanced imaging techniques in diagnosing rare causes suggests that surgical options may still be valid for such presentations.
Category: Trauma Introduction/Purpose: Fibular fractures are one of the most common traumatic injuries treated by orthopaedic surgeons. These range from stable to unstable, and accordingly may be conservatively with immobilization or operatively open reduction internal fixation. Unstable Weber classification type B fibula at level syndesmosis. When stressed, they show an increased medial clear space widening. Recent studies have suggested these non-operatively. The purpose this study was...
# Abstract 57. Radiographic reporting in adolescent idiopathic scoliosis: Is there a discrepancy comparing radiologists’ reports and surgeons’ assessments? {#article-title-2} Cobb angle measurement is the standard method for quantification of scoliosis (AIS),
Paget's disease is a metabolic bone disorder characterized by abnormal patterns in remodeling, resulting variable degrees of chronic pain, deformation the long bones and rarely, pathologic fracture. These issues can pose difficult surgical challenges, particularly elderly frail population, where benefits orthopedic intervention must be balanced with minimizing inherent risks. Such considerations often include reducing operative time blood loss, allowing for early mobilization, stabilizing an...
Abstract Osteosarcoma(OS) is a highly aggressive bone cancer for which treatment has remained essentially unchanged decades. Although OS characterized by extensive genomic heterogeneity and instability, RB1 TP53 have been shown to be the most commonly inactivated tumor suppressors in OS. We previously generated mouse model with double knockout (DKO) of Rb1 Trp53 within cells osteoblastic lineage, largely recapitulates human nearly complete penetrance. SKP2 repression target pRb serves as...
Category: Trauma Introduction/Purpose: INTRODUCTION: Talus fractures are not uncommon and one of the serious in foot ankle. Peroneal tendon dislocation is commonly missed soft tissue injuries which may have significant impact on outcomes including persistent pain swelling. AIM: To report incidence peroneal talus fracture significance fleck sign diagnosis dislocation. Methods: We retrospectively reviewed 100 consecutive period between 1/1/2011 to 1/7/2017. Inclusion criteria were: The patient...