A5053695231- Cardiac, Anesthesia and Surgical Outcomes
- Antibiotic Resistance in Bacteria
- Yersinia bacterium, plague, ectoparasites research
- Vibrio bacteria research studies
- Cardiac Structural Anomalies and Repair
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Legionella and Acanthamoeba research
- Cardiac Arrest and Resuscitation
- Immune Response and Inflammation
- Cardiac Imaging and Diagnostics
- Pediatric health and respiratory diseases
- Case Reports on Hematomas
- Transplantation: Methods and Outcomes
- Mechanical Circulatory Support Devices
- Aortic Disease and Treatment Approaches
- Bacillus and Francisella bacterial research
- Cardiac pacing and defibrillation studies
- Spinal Fractures and Fixation Techniques
- Ultrasound in Clinical Applications
- Cardiac Valve Diseases and Treatments
- Congenital Heart Disease Studies
- Toxoplasma gondii Research Studies
- Cardiac Health and Mental Health
- Clostridium difficile and Clostridium perfringens research
- Acute Myocardial Infarction Research
Stanford Medicine
2024
Stanford University
2023
University of Pennsylvania
2014-2020
The innate immune system is critical for host defense against microbial pathogens, yet many pathogens express virulence factors that impair function. Here, we used the bacterial pathogen Legionella pneumophila to understand how successfully overcomes subversion mechanisms. L. replicates within macrophages by using a type IV secretion translocate effectors into cell cytosol. As consequence of effector delivery, protein synthesis blocked at several steps, including translation initiation and...
ABSTRACT Legionella pneumophila , an intracellular pathogen responsible for the severe pneumonia Legionnaires' disease, uses its dot/icm -encoded type IV secretion system (T4SS) to translocate effector proteins that promote survival and replication into host cell cytosol. However, by introducing bacterial products cytosol, L. also activates cytosolic immunosurveillance pathways, thereby triggering robust proinflammatory responses mediate control of infection. Thus, pulmonary types infects...
The use of ventricular assist devices (VADs) as a bridge to heart transplant (HT) is increasing, while HT volume remains stagnant. This may portend longer waiting times and an otherwise more competitive environment for all patients on the list. A retrospective analysis who were listed in United Network Organ Sharing (UNOS) database from 2000 2015 was conducted. Mean time, proportion reception (%HT), death (%death), list removal (%removal) calculated across three eras: Era 1 (2000-2007), 2...
Abstract The innate immune system responds to virulent pathogens, yet many pathogens manipulate host signaling pathways which should limit activation. To understand how the overcomes pathogenic manipulation we study intracellular bacterium Legionella pneumophila, cause of severe pneumonia Legionnaire’s disease. utilizes a type IV secretion inject bacterial proteins into cytosol infected cells. Several these effector inactivate cell factors involved in protein translation. Despite...
A 70-year-old woman who underwent mitral valve replacement for endocarditis in 2013 and redo recurrent 2014 presented with acute back pain attributable to a distal aortic occlusive thrombus. Chest radiography incidentally demonstrated retained epicardial pacing wire migrating through the left side of chest (Figure 1; white dots denote wire's 2 ends). Computed tomography angiography traversing hilum adjacent superior pulmonary vein main artery 2). Multiplanar reformation 2A) 3-dimensional...