A5060899930- Genital Health and Disease
- Cervical Cancer and HPV Research
- Urologic and reproductive health conditions
- Urological Disorders and Treatments
- Cancer and Skin Lesions
- Nonmelanoma Skin Cancer Studies
- Colorectal and Anal Carcinomas
- Reproductive tract infections research
- Cutaneous Melanoma Detection and Management
- Endometrial and Cervical Cancer Treatments
- Cancer-related Molecular Pathways
- Advances in Oncology and Radiotherapy
- COVID-19 and healthcare impacts
- Autoimmune Bullous Skin Diseases
- HIV, Drug Use, Sexual Risk
- HIV/AIDS Research and Interventions
- Skin and Cellular Biology Research
- Cancer Genomics and Diagnostics
- Fetal and Pediatric Neurological Disorders
- Microbial infections and disease research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cancer Diagnosis and Treatment
- Global Cancer Incidence and Screening
- Histiocytic Disorders and Treatments
- Ovarian cancer diagnosis and treatment
Ikazia Ziekenhuis
2019-2024
Vrije Universiteit Amsterdam
2022
Amsterdam University Medical Centers
2022
Radboud University Nijmegen
2005-2011
Radboud University Medical Center
2005-2011
Zero to Three
2008
Two separate pathways leading to vulvar carcinoma have been suggested. First, a human papillomavirus (HPV)-dependent pathway, in which premalignant stages of cancer are the classic intraepithelial neoplasia (VIN) lesions. Second, an HPV-independent associated with differentiated VIN III lesions and/or lichen sclerosus. To obtain insight into mechanisms underlying these pathways, we determined relationship between HPV DNA and expression p14(ARF) p16(INK4A) non- (pre)malignant Seventy-three...
Abstract Purpose: Biomarker detection in urine offers a potential solution to increase effectiveness of cervical cancer screening programs by attracting nonresponders. In this prospective study, the presence high-risk human papillomavirus (hrHPV) DNA and performance methylation analysis was determined for high-grade intraepithelial neoplasia (CIN2/3) urine, compared with paired cervicovaginal self-samples clinician-taken scrapes. Experimental Design: A total 587 samples were included from...
Two pathways leading to vulvar squamous cell carcinoma (SCC) exist. The expression of proliferation- and cell-cycle-related biomarkers the presence high-risk (hr) HPV might be helpful distinguish premalignancies in both pathways. Seventy-five differentiated intra-epithelial neoplasia (VIN)-lesions with adjacent SCC 45 usual VIN-lesions (32 solitary 13 SCC) were selected, tested for hr-HPV DNA, using a broad-spectrum detection/genotyping assay (SPF(10)-LiPA), immunohistochemical MIB1,...
The COVID-19-pandemic caused drastic healthcare changes worldwide. To date, the impact of these on gynecological cancer is relatively unknown. This study aimed to assess surgical gynecological-oncology healthcare.This population-based cohort included all procedures with curative intent for malignancies, registered in Dutch Gynecological Oncology Audit, 2018-2020. Four periods were identified based COVID-19 hospital admission rates: 'Pre-COVID-19', 'First wave', 'Interim period', and 'Second...
Vulvar lichen sclerosus (VLS) occurs in at least one 900 girls. There is limited knowledge as to what extent the disease persists adulthood and repercussions may be. The aim of this study evaluate long-term consequences VLS diagnosed childhood or adolescence.The population females histologically with adolescence Netherlands between 1991 2015 was identified through national pathology database. Histological specimens were retrieved re-evaluated. Potential participants for whom diagnosis...
The effectiveness of cervical cancer screening is hampered by low attendance rates. collection a urine sample hypothesized to engage non-attenders in screening. aim this prospective cohort study was evaluate experiences women on and cervicovaginal self-sampling home-based setting preferences for future This included 140 women, with median age 40 years, who were planned large loop excision the transformation zone (LLETZ) procedure. All collected using conventional cups self-sample prior LLETZ...
Objectives Studies on the consequences of juvenile vulvar lichen sclerosus (JVLS) in adulthood are limited. A number measuring tools available for analyzing adult (VLS), but these have not been applied studies JVLS. The aim is to study physical findings, quality life, sexual well-being, and self-image women with a history VLS. Materials Methods Adult biopsy proven JVLS were recruited be examined surveyed using standardized measurement tools. This took place an outpatient setting by...
Genital lichen sclerosus (LS), a chronic noninfectious dermatosis, is not rare in pediatric dermatology. The histopathological diagnosis children and adults both genital nongenital LS considered to be the same encompasses broad range of possible characteristics. Clinical manifestations treatment options are different depending on gender. vast majority boys treated with circumcision, making for larger amount information histopathology boys, whereas substantial juvenile vulvar lacking. In...
Taking a biopsy is standard procedure to make the correct diagnosis in patients with suspicious premalignant vulvar lesions. The use of less invasive diagnostic tool as triage instrument determine whether necessary may improve patient comfort especially chronic disorders that warrant consecutive biopsies. This study was conducted investigate brush cytology feasible and be used detect (pre)malignant lesions.A pilot performed having clinically normal skin, lichen sclerosus (LS), usual or...
To compare the treatment and follow-up of patients with lichen sclerosus (LS) at departments Gynaecology Dermatology Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, to evaluate need for a multidisciplinary vulvar clinic.Treatment data all women histologically proven (between January 1995 2001) anogenital LS visiting outpatient clinics Obstetrics & were collected (last date follow-up: 2008).Eighty-four included in this study, 10 (12%) which treated by both specialties. At...
With great interest we read the review article by Sim et al1 recently published online in Skin Health and Disease on relation of genital lichen sclerosus (LS) to melanoma. We would like bring attention readers your journal our recent scoping population study2 juvenile vulvar melanocytic lesions including There are some striking differences between two reviews, especially regarding conclusions recommendations made. al included 5 cases childhood melanoma with concomitant LS, all girls 12 years...
Abstract Background Vulvar lichen sclerosus (VLS) is a chronic remitting condition that affects the genital skin of females all ages. Although qualitative studies have been conducted focused on women with VLS in mid-life or beyond, less known about experiences individuals from childhood adolescence onward. Objectives To gain an understanding history juvenile (JVLS) regard to impact disease their personal lives, and needs regarding care guidance. Methods A study was consisting 27 in-depth...