A5078174122- Glioma Diagnosis and Treatment
- Parasites and Host Interactions
- Radiomics and Machine Learning in Medical Imaging
- Gut microbiota and health
- Educational Research and Methods
- Statistical Methods in Clinical Trials
- Ferroptosis and cancer prognosis
- Cancer Genomics and Diagnostics
- Statistical Methods and Bayesian Inference
- Cervical Cancer and HPV Research
- Pharmacovigilance and Adverse Drug Reactions
- Vitamin D Research Studies
- Colorectal and Anal Carcinomas
- Epigenetics and DNA Methylation
- Influenza Virus Research Studies
- Bayesian Methods and Mixture Models
- Parasite Biology and Host Interactions
- Advanced Causal Inference Techniques
- Genital Health and Disease
- Microtubule and mitosis dynamics
- SARS-CoV-2 and COVID-19 Research
- Vocational and Entrepreneurial Education
- Education Systems and Policies
- Clostridium difficile and Clostridium perfringens research
- Survey Sampling and Estimation Techniques
University Medical Center Utrecht
2024-2025
The University of Texas MD Anderson Cancer Center
2025
Amsterdam University Medical Centers
2021-2024
University of Amsterdam
2024
Tergooi
2022
Vrije Universiteit Amsterdam
2021
Parahyangan Catholic University
2015-2019
Leiden University Medical Center
2015-2019
Hospital Universitario Virgen Macarena
2019
Abstract Purpose: Biomarker detection in urine offers a potential solution to increase effectiveness of cervical cancer screening programs by attracting nonresponders. In this prospective study, the presence high-risk human papillomavirus (hrHPV) DNA and performance methylation analysis was determined for high-grade intraepithelial neoplasia (CIN2/3) urine, compared with paired cervicovaginal self-samples clinician-taken scrapes. Experimental Design: A total 587 samples were included from...
Background Microbiome studies suggest the presence of an interaction between human gut microbiome and soil-transmitted helminth. Upon deworming, a complex anthelminthic drug, helminths composition might occur. To dissect this, we analyse changes that take place in bacteria profiles samples from double blind placebo controlled trial conducted area endemic for soil transmitted Indonesia. Methods Either or albendazole were given every three months period one half years. Helminth infection was...
Abstract Colorectal cancer (CRC) is the second leading cause for cancer-related death globally. Clinically, there an urgent need non-invasive CRC detection. This study assessed feasibility of detection by analysis tumor-derived methylated DNA fragments in urine. Urine samples, including both unfractioned and supernatant urine fractions, 92 patients 63 healthy volunteers were analyzed methylation levels 6 CRC-associated markers ( SEPT9 , TMEFF2 SDC2 NDRG4 VIM ALX4 ). Optimal marker panels...
Emerging evidence suggests that helminth infections are associated with lower insulin resistance (IR). Current deworming programs might remove this helminth-associated protective effect. Therefore, we evaluated the anthelmintic treatment effect on changes in IR.We conducted a double-blind, household-cluster-randomized, placebo-controlled clinical trial Flores island, Indonesia, an area endemic for soil-transmitted helminths (STHs). All subjects received 4 rounds of albendazole or matching...
Insulin resistance is a strong predictor of the development type 2 diabetes mellitus. Chronic helminth infections might protect against insulin via caloric restriction state and indirectly T-helper-2 polarization immune system. Therefore elimination helminths remove this beneficial effect on resistance. To determine whether soil-transmitted are associated with better whole-body sensitivity protection reversible by anthelmintic treatment, household-based cluster-randomized, double blind,...
Abstract Esophageal adenocarcinoma is a prevalent and serious disease, ranking eighth globally, with low survival rate of 15-25% rising incidence in the United States. However, occurrence brain metastasis esophageal (EAC) rare, affecting only approximately 2-6%. Despite its rarity, EAC associated poor prognosis, compounded by limited availability effective treatment options. Due to infrequent patients, our understanding tumor composition these cases how they differ from those primary sites...
Background: Soil-transmitted helminths have been shown to the immune regulatory capacity, which they use enhance their long term survival within host. As these parasites reside in gastrointestinal tract, might modulate system through altering gut bacterial composition. Although relationships between helminth infections or microbiome with studied separately, combined interactions are largely unknown. In this study we aim analyze relationship communities cytokine response presence absence of...
Anal cancer has increasing incidence and is preceded by high-grade anal intraepithelial neoplasia (HGAIN; AIN2-3). Previously, we identified validated several methylation markers for accurate detection of HGAIN with risk in HIV-positive (HIV+) men who have sex (MSM). This study aimed to evaluate these HIV-negative groups. A cross-sectional series 176 tissue samples cancer, AIN3, AIN2, AIN1 control biopsies obtained women was tested six (ASCL1, LHX8, SST, WDR17, ZIC1 ZNF582). Accuracy AIN3...
Clustered overdispersed multivariate count data are challenging to model due the presence of correlation within and between samples. Typically, first source needs be addressed but its quantification is less interest. Here, we focus on time points. In addition, effects covariates counts distribution need assessed. To fulfill these requirements, a regression based Dirichlet‐multinomial for association categorical extended by using random deal with additional clustering. This mixed model....
1 Abstract To study the evolutionary processes that drive malignant progression of IDH-mutant astrocytomas, we performed multi-omics on a large cohort matched initial and recurrent tumor samples. The overlay genetic, epigenetic, transcriptomic proteomic data, combined with single-cell analysis, have identified overlapping features associated progression. These are derived from three molecular mechanisms provide rationale underlying biology malignancy: cell-cycling, cell (de-)differentiation...
The aim of this study was to assess the possible extent bias due violation a core assumption (event-dependent exposures) when using self-controlled designs analyse association between COVID-19 vaccines and myocarditis.
Abstract Emerging evidence suggests that helminths might confer protection against the development of type 2 diabetes. We aimed to assess role adipokines in mediating effect on insulin resistance. Serum samples were obtained from a randomized-controlled trial anthelmintic treatment an area endemic for soil-transmitted (STH), Flores Island, Indonesia. In STH-infected subjects, significantly increased ratio leptin adiponectin (treatment factor (95% confidence interval (CI)), P -value...
<title>Abstract</title> To study the evolutionary processes that drive malignant progression of IDH-mutant astrocytomas, we performed multi-omics on a large cohort matched initial and recurrent tumor samples. The overlay genetic, epigenetic, transcriptomic proteomic data, combined with single-cell analysis, have identified overlapping features associated progression. These are derived from three molecular mechanisms provide rationale underlying biology malignancy: cell-cycling, cell...
To study the evolutionary processes that drive malignant transformation in IDH-mutant astrocytomas, we performed multi-omics on a large cohort of matched initial and recurrent tumor samples. We find genome-wide DNA-methylation levels decreased over time, mainly patients with high-grade recurrences. DNA-demethylation was lifted from specific loci associated DNA replication, upregulation cell cycling genes. Upregulation genes occurred predominantly proliferating cells, grade. Temporal were...
<title>Resumen</title> El cáncer de páncreas (CP) es la cuarta causa muerte por en el mundo occidental. La única opción supervivencia a largo plazo resección quirúrgica radical seguida quimioterapia adyuvante, cual puede ser realizada alrededor del 20% los pacientes momento diagnóstico. interés una cirugía para lograr completa R0 y mejorar sometidos pancreatectomía adenocarcinoma ductal ha sido renovado. Esta incluye resecciones arteriales venosas sincrónicas combinación con estrategias...
Abstract INTRODUCTION. Diffuse gliomas are the most frequent and devastating primary CNS tumors in adults. Standard treatment has limited efficacy without exception these recur. The evolutionary processes that drive progression glioma of IDH-mutant astrocytoma subgroup, remain unclear. GLASS-NL consortium was initiated to gain insight into molecular mechanisms underlying evolution identify markers astrocytomas. Such can ultimately assist clinical decision making. Here, we present results...
Abstract BACKGROUND The evolutionary processes that drive progression in patients with IDH-mutant astrocytoma remain unclear. GLASS-NL consortium, as part of the larger worldwide GLASS was initiated to gain insight into molecular mechanisms underlying glioma evolution and identify markers astrocytomas. Such can ultimately assist clinical decision making. Here, we present first results genome wide methylation profiling samples included study. MATERIAL AND METHODS 110 adult were identified an...