A5015493240- Microfluidic and Bio-sensing Technologies
- Microfluidic and Capillary Electrophoresis Applications
- 3D Printing in Biomedical Research
- Biosensors and Analytical Detection
- Microbial Inactivation Methods
- Innovative Microfluidic and Catalytic Techniques Innovation
- Advanced Sensor and Energy Harvesting Materials
- Electrohydrodynamics and Fluid Dynamics
- Cell Image Analysis Techniques
- Muscle activation and electromyography studies
- Transgenic Plants and Applications
- Nanofabrication and Lithography Techniques
- Advanced biosensing and bioanalysis techniques
- Single-cell and spatial transcriptomics
- Algal biology and biofuel production
- Tactile and Sensory Interactions
- Advanced Biosensing Techniques and Applications
- Cellular Mechanics and Interactions
- Blood properties and coagulation
- Electrowetting and Microfluidic Technologies
- Neurofibromatosis and Schwannoma Cases
- Erythrocyte Function and Pathophysiology
- Prosthetics and Rehabilitation Robotics
- Nanopore and Nanochannel Transport Studies
- Neuroscience of respiration and sleep
Kyung Hee University
2015-2024
Kosin University Gospel Hospital
2019-2023
Kosin University
2017-2022
Yong In University
2017-2020
Government of the Republic of Korea
2016-2020
Kangwon National University Hospital
2019
Samsung Medical Center
2016
Sungkyunkwan University
2016
Gyeonggi Research Institute
2016
Massachusetts Institute of Technology
2009-2011
Point-of-care (POC) diagnostics is playing an increasingly important role in public health, environmental monitoring, and food safety analysis. Smartphones, alone or conjunction with add-on devices, have shown great capability of data collection, analysis, display, transmission, making them popular POC diagnostics. In this article, the state-of-the-art advances smartphone-based diagnostic technologies their applications past few years are outlined, ranging from <italic...
In this article, we describe an approach to generate microporous cell-laden hydrogels for fabricating biomimetic tissue engineered constructs. Micropores at different length scales were fabricated in by micromolding fluidic channels and leaching sucrose crystals. Microengineered created within hydrogel precursors containing agarose solution mixed with The rapid cooling of the was used gel form micropores place process generated homogeneously distributed gels, while enabling direct...
We describe a microfluidic device for generating nonlinear (exponential and sigmoidal) concentration gradients, coupled with microwell array cell storage analysis. The has two inputs coflowing multiple aqueous solutions, main coflow channel an asymmetrical grid of fluidic channels that allows the solutions to combine at intersection points without fully mixing. Due this asymmetry diffusion species in channel, varying amounts enter each path. This induces exponential sigmoidal gradients low...
Abstract Here we present a new method for automatic and objective monitoring of ingestive behaviors in comparison with other facial activities through load cells embedded pair glasses, named GlasSense. Typically, activated by subtle contraction relaxation temporalis muscle, there is cyclic movement the temporomandibular joint during mastication. However, such muscular signals are, general, too weak to sense without amplification or an electromyographic analysis. To detect these oscillatory...
In conventional hanging drop (HD) methods, embryonic stem cell aggregates or embryoid bodies (EBs) are often maintained in small inverted droplets. Gravity limits the volumes of these droplets to less than 50 microL, and hence such cultures can only be sustained for a few days without frequent media changes. Here we present new approach performing long-term HD methods (10-15 days) that provide larger reservoirs format maintain more consistent culture conditions. To implement this approach,...
Microstructures that generate shear-protected regions in microchannels can rapidly immobilize cells for cell-based biosensing and drug screening. Here, a two-step fabrication method is used to double microgrooves with various depth ratios achieve controlled double-level cell patterning while still providing shear protection. Six microgroove geometries are fabricated different groove widths ratios. Two modes of docking observed: docked upstream sufficiently deep narrow grooves, downstream...
We presented a benchtop technique that can fabricate reconfigurable, three-dimensional (3D) microfluidic devices made from soft paper–polymer composite. This fabrication approach produce microchannels at minimal width of 100 μm and be used to prototype 3D by simple bending stretching. The entire process finished in 2 hours on laboratory bench without the need for special equipment involved lithography. Various functional (e.g., droplet generator reconfigurable electronic circuit) were...
Circulating tumor DNA (ctDNA) detection has found widespread applications in diagnostics and treatment, where the key is to obtain accurate quantification of ctDNA. However, this remains challenging due issue background noise associated with existing assays. In work, we developed a synthetic gene circuit-based assay multilevel switch (termed CATCH) for background-free absolute The combining small transcription activating RNA toehold was designed simultaneously regulate translation processes...
Continuous culture for the production of ethanol from wood hydrolysate was carried out in an internal membrane-filtration bioreactor. The medium sterilized at a relatively low temperature 60 °C with intention reducing formation inhibitory compounds during sterilization. maximum concentration and productivity obtained this study were 76.9 g/L 16.9 g/L-h, respectively, which much higher than those (57.2–67 0.3–1.0 g/L-h) batch cultures using media °C. also found to be that (6.7 continuous cell...
This paper presents a novel method for an on-chip erythrocyte deformability test under optical pressure, especially to enhance the level of sensitivity with respect detection cancerous diseases. To demonstrate performance and combined method, we introduce concept transit velocity, modified elongation index, shape recovery time individual erythrocytes in strictly confined region (2 µm deep, 4 wide, 100 long). Finally, investigate synergy or convergence effect due combination these parameters...
This paper presents direct visualization of uptake directionality for cell-membrane impermeant fluorescent molecules and fluorescence-doped nanoparticles at a single-cell level during electroporation. To observe directly the direction, we used microchannel-type electroporation that can generate relatively symmetric uniform electric field. For all image frames electroporation, fluorescence intensities occurred cell membranes in both directions toward electrodes have been sequentially recorded...