A5018144501- Heavy Metal Exposure and Toxicity
- Mercury impact and mitigation studies
- Oral microbiology and periodontitis research
- Dental Erosion and Treatment
- Dental Health and Care Utilization
- Bone and Dental Protein Studies
- Fluoride Effects and Removal
- Neuroinflammation and Neurodegeneration Mechanisms
- Dental materials and restorations
- Neuroscience and Neuropharmacology Research
- Aluminum toxicity and tolerance in plants and animals
- Trace Elements in Health
- Anesthesia and Neurotoxicity Research
- Salivary Gland Disorders and Functions
- Endodontics and Root Canal Treatments
- Dental Radiography and Imaging
- Dental Anxiety and Anesthesia Techniques
- Air Quality and Health Impacts
- dental development and anomalies
- Selenium in Biological Systems
- Oral and Maxillofacial Pathology
- Alcohol Consumption and Health Effects
- Biochemical effects in animals
- Temporomandibular Joint Disorders
- Sesquiterpenes and Asteraceae Studies
Universidade Federal do Pará
2016-2025
Hospital de Clínicas Universidade Federal do Paraná
2024
Institut des Sciences Biologiques
2017-2023
Amazon Research Foundation
2017-2018
In-Q-Tel
2018
Mercury is a toxic metal that can be found in the environment three different forms – elemental, organic and inorganic. Inorganic mercury has lower liposolubility, which results organism absorption reduced passage through blood–brain barrier. For this reason, exposure models use inorganic rats order to evaluate its effects on central nervous system are rare, especially adult subjects. This study investigated if chronic low doses of chloride (HgCl2), an form mercury, capable promoting motor...
The delayed healing of wounds among people with diabetes is a severe problem worldwide. Hyperglycemia and increased levels free radicals are the major inhibiting factors wound in diabetic patients. Plant extracts rich source polyphenols, allowing them to be an effective agent for healing. Drying temperature extraction solvent highly affect stability polyphenols plant materials. However, there need optimize protocol ensure efficacy final product. For this purpose, effects drying solvents on...
Binge drinking is common among adolescents, and this type of ethanol exposure may lead to long-term nervous system damage. In the current study, we evaluated motor performance tissue alterations in cerebral cortex rats subjected intermittent intoxication with from adolescence adulthood. Adolescent male Wistar (35 days old) were treated distilled water or (6.5 g/kg/day, 22.5% w/v) during 55 by gavage complete 90 age. The open field, inclined plane rotarod tests used assess spontaneous...
Mercury (Hg) is a highly toxic metal, which can be found in its inorganic form the environment. This presents lower liposolubility and absorption body. In order to elucidate possible toxicity of Hg hippocampus, we investigated potential low doses mercury chloride (HgCl2) promote hippocampal dysfunction by employing chronic exposure model. For this, 56 rats were exposed HgCl2 (0.375 mg/kg/day) via oral route for 45 days. After period, animals submitted cognitive test fear memory. The...
The excessive fluoride (F) exposure is associated with damage to cellular processes of different tissue types, due changes in enzymatic metabolism and breakdown redox balance. However, few studies evaluate doses F compatible human consumption. Thus, this study evaluated the effects chronic sodium (NaF) on peripheral blood mice from evaluation biochemical parameters. animals were divided into three groups (n = 10) received concentrations NaF drinking water for 60 days: 0 mg/L F, 10 50 F. was...
Long-term exposure to high concentrations of fluoride (F) can damage mineralized and soft tissues such as bones, liver, kidney, intestine, nervous system adult rats. The permeability the blood–brain barrier placenta F during pregnancy lactation may be critical neurological development. Therefore, this study aimed investigate effects on molecular processes oxidative biochemistry offspring rats' hippocampus. Pregnant Wistar rats were randomly assigned into 3 groups in accordance with drinking...