A5055722278- Pharmaceutical Practices and Patient Outcomes
- Healthcare Systems and Reforms
- Diverse Scientific Research Studies
- Biochemical effects in animals
- Marine Sponges and Natural Products
- Malaria Research and Control
- Anesthesia and Sedative Agents
- Healthcare during COVID-19 Pandemic
- Pharmaceutical studies and practices
- Antioxidant Activity and Oxidative Stress
- Public Health in Brazil
- Sirtuins and Resveratrol in Medicine
- Marine Toxins and Detection Methods
- Healthcare Regulation
- Fluoride Effects and Removal
- Methemoglobinemia and Tumor Lysis Syndrome
- Medical and Biological Ozone Research
- Coffee research and impacts
- Healthcare Systems and Public Health
- Historical Medical Research and Treatments
- Echinoderm biology and ecology
- Coral and Marine Ecosystems Studies
- Seaweed-derived Bioactive Compounds
- Autophagy in Disease and Therapy
- Alcoholism and Thiamine Deficiency
Universidade Federal do Pará
2008-2025
Universidade Federal do Ceará
2015-2017
University of Coimbra
2015
The excessive fluoride (F) exposure is associated with damage to cellular processes of different tissue types, due changes in enzymatic metabolism and breakdown redox balance. However, few studies evaluate doses F compatible human consumption. Thus, this study evaluated the effects chronic sodium (NaF) on peripheral blood mice from evaluation biochemical parameters. animals were divided into three groups (n = 10) received concentrations NaF drinking water for 60 days: 0 mg/L F, 10 50 F. was...
Background/Objectives: Chronic treatment with dapsone (DDS) has been linked to adverse reactions involving all organ systems, such as hypersensitivity syndrome, methemoglobinemia and hemolytic anemia, besides neuroinflammation neurodegeneration due iron accumulation oxidative stress. These effects probably occur the presence of its toxic metabolite DDS-NOH, which can generate reactive oxygen species (ROS) overload. In this sense, antioxidant compounds chelating properties, alpha-lipoic acid...
Recent evidence suggests that replacing saturated fat with unsaturated is beneficial for cardiovascular health. This study compared the effects of Brazil nut oil (BNO) and soybean (SO) supplementation 30 days on anthropometric, blood pressure, biochemical, oxidative parameters in patients metabolic syndrome (MS). Thirty-one MS were randomly allocated to receive sachets 10 mL each either BNO (n = 15) or SO 16) daily supplementation. Variables measured at beginning after intervention. No...
Malaria infection can cause high oxidative stress, which could lead to the development of severe forms malaria, such as pulmonary malaria. In recent years, role reactive oxygen species in pathogenesis disease has been discussed, well potential benefit antioxidants supplementation. The aim this study was investigate effects N-acetyl cysteine (NAC) or mushroom Agaricus sylvaticus supplementation on changes an experimental model malaria caused by Plasmodium berghei strain ANKA. Swiss male mice...
Benthic cnidarians are colonial marine animals that host a rich population of associated and symbiotic microorganisms. In recent paper we described for the first time isolation amphidinolide P (1) from Brazilian octocoral Stragulum bicolor. Amphidinolides similar compounds had been previously reported only dinoflagellates genus Amphidinium; thus presence 1 in invertebrate opens intriguing questions on role occurrence these molecules ecosystems. Here report identification four further...
Dinoflagellates are an important source of unique bioactive secondary metabolites. Symbiotic species, commonly named zooxanthellae, transfer most their photosynthetically fixed carbon to host. The mutualistic relationship provides the organic metabolites used for energy production but there very few reports role dinoflagellates in symbiotic association. Corals and other related cnidarians well-known animals containing dinoflagellates. In present paper we describe isolation amphidinolide P...
The chemical study of the Brazilian brittle star Ophionereis reticulata led to isolation three chamigrene sesquiterpenes, including partially characterized isoobtusadiene (1), its unreported acetyl derivative (2), and known (+)-elatol (3). complete elucidation structures 1 2 was accomplished by 1D 2D NMR spectroscopy. first assignment absolute configuration skeleton is suggested as 6S,9R,10S on basis analysis Mosher's ester derivatives ECD 2. Chamigrenes are typical constituents Laurencia...
A degeneração macular relacionada à idade (DMRI) é uma das maiores causas de cegueira em pessoas com mais 55 anos nos países industrializados. Está ao estresse oxidativo, hipóxia, inflamação e mudanças degenerativas da matriz extracelular. Pode ser classificada em: tardia, intermediária ou precoce. O mecanismo fisiopatológico DMRI ocorre por redução difusão oxigênio, proliferação fatores crescimento, o importante fator crescimento endotelial vascular (VEGF). Para tratar a progressão novos...
Objetivo: Estruturar e avaliar o serviço de reconciliação medicamentosa (RM) em um hospital universitário (HU) no Pará para garantir segurança farmacoterapêutica na admissão pacientes Métodos: Pesquisa-ação clínica infectologia (UDIP) utilizando modelo proposto por Moulin et al., (2016) seguindo as etapas implantação serviço: Exploração (analisou a viabilidade execução do projeto realizando diagnóstico situacional (DS) escolha da piloto), preparação (fundamentação teórica construção fluxo...
The aim of this work is to evaluate the methodology obtain an extract rich in caffeic acid (CAD) derivatives spent coffee ground (SCG) and its free radical scavenging activity. Eighteen SCG samples beverage were collected from different brands shops. extracts prepared by three methods: A) ethanol 96o according Campos et al [1]; B) A hydrolysed with HCl 37% (1:10), Markham [2]; C) water extraction. All screened HPLC/DAD for phenolic profile characterization structural identification...
Objetivo: Identificar e descrever a prevalência potenciais interações medicamentosas (PIM) em pacientes internados com doenças respiratórias durante período de inverno amazônico, buscando também classificar PIM função do risco o manejo clínico. Métodos: Um estudo descritivo, tipo transversal, retrospectivo, abordagem quantitativa internado no hospital universitário amazônico. Foram selecionados 40 analisadas 120 prescrições, coletando dados como identificação paciente, hipótese diagnóstico,...