A5015379104- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Organ Donation and Transplantation
- Liver Disease and Transplantation
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Disease Diagnosis and Treatment
- Clinical Nutrition and Gastroenterology
- Congenital Anomalies and Fetal Surgery
- Renal Diseases and Glomerulopathies
- Social Media in Health Education
- Neutropenia and Cancer Infections
- Organ and Tissue Transplantation Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Renal and Vascular Pathologies
- Pregnancy and Medication Impact
- Pharmacological Effects and Toxicity Studies
- Pancreatic and Hepatic Oncology Research
- Adrenal Hormones and Disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Genomics and Diagnostics
- Adrenal and Paraganglionic Tumors
- Pituitary Gland Disorders and Treatments
- Patient-Provider Communication in Healthcare
- Intestinal Malrotation and Obstruction Disorders
Scripps Clinic
2006-2022
Scripps MD Anderson Cancer Center
2019-2022
University of California, San Diego
2022
University of Southern California
2022
Scripps Institution of Oceanography
2006-2022
Scripps Green Hospital
2017-2020
Scripps Health
2009-2018
Epic Sciences (United States)
2014
Université de Montréal
2014
Collaborative Group (United States)
2014
There are no minimally invasive diagnostic metrics for acute kidney transplant rejection (AR), especially in the setting of common confounding diagnosis, dysfunction with (ADNR). Thus, though biopsies remain gold standard, they invasive, have substantial risks, sampling error issues and significant costs not suitable serial monitoring. Global gene expression profiles 148 peripheral blood samples from patients excellent function normal histology (TX; n = 46), AR (n 63) ADNR 39), two...
The role of liver biopsy (LB) in donor selection for adult living transplantation remains controversial, since the procedure is associated with additional potential risks donor. From April 1998 to August 2004, 730 donors 337 recipients underwent our multistep evaluation program. In 144 candidates, LB was performed. obtained a percutaneous ultrasound-guided fashion by means Menghini needle (32 cases) or Tru-cut (112 cases). specimen preserved 5% formalin and processed hematoxylin &...
Despite significant improvements in life expectancy of kidney transplant patients due to advances surgery and immunosuppression, Chronic Allograft Nephropathy (CAN) remains a daunting problem. A complex network cellular mechanisms both graft peripheral immune compartments complicates the non-invasive diagnosis CAN, which still requires biopsy histology. This is compounded by non-immunological factors contributing injury. There pressing need identify validate minimally invasive biomarkers for...
The purpose of this study was to determine indications for gallbladder surgery and risk factors urgent surgery.We reviewed all patients <19 years old, who underwent cholecystectomy between 1980 1996.There were 128 (mean age: 10 years). Fifty-two had an underlying hematologic disorder, 47 another medical 29 no preexisting illness or identifiable factor gallstone disease. Twenty-five percent (32/128) cholecystectomies performed urgently. Postoperative complications developed in 5 32 (16%)...
As the organ shortage continues to grow, creation of social media communities by transplant hospitals and public is rapidly expanding increase number living donors. Social are arranged in myriad ways without standardization, raising concerns about candidates' potential donors' autonomy quality care. magnify modify extant ethical issues deceased donation related privacy, confidentiality, professionalism, informed consent, for undue influence coercion donors candidates. Currently, no national...
Social media platforms are increasingly used in surgery and have shown promise as effective tools to promote deceased donation expand living donor transplantation. There is a growing need understand how social media-driven communication perceived by providers the field of
February 27, 2002, allocation of cadaver livers for transplantation changed from a waiting-time-based system to an evidence-based referred as the Model End-Stage Liver Disease (MELD). We reviewed data 1 11 United Network Organ Sharing regions determine impact MELD on in that region. The region interest (study region) consists three distinct geographic areas (referred Transplant Service Areas [TSAs]). Based information obtained Procurement and Transplantation States study region, following...
A major challenge for the field of transplantation is lack understanding genomic and molecular drivers early post-transplant immunity. The immune response creates a complex milieu that determines course ensuing events ultimate outcome transplant. objective current study was to mechanistically deconvolute by purifying profiling constituent cell subsets peripheral blood. We employed genome-wide whole blood purified CD4, CD8, B cells monocytes in tandem with high-throughput laser-scanning...
Background. Use of kidneys from donors aged 75 years and older is controversial. The purpose this study was to evaluate the outcome kidney transplantation (KT) involving these expanded criteria donors. Materials Methods. From January 2001 November 2009, 52 patients were transplanted with grafts deceased older. Donor recipient data intra- postoperative variables analyzed by univariate multivariate regression analyses. Graft patient survival calculated using Kaplan-Meier method. Results....
In this study, we present our experience with 4 healthy donors having the rare condition of "hepar divisum" after intraoperative death recipient an intended right adult living donor liver transplantation (LDLT). The study included and LDLT recipients affected by neuroendocrine tumor (n = 2), hepatocellular carcinoma 1), cryptogenic cirrhosis 1). All died intraoperatively. At time death, dissection parenchyma was complete, vessels intact, hepatic duct(s) already divided. each case,...
As cancer care is transitioning to personalized therapies with necessary complementary or companion biomarkers there significant interest in determining what extent non-invasive liquid biopsies reflect the gold standard solid biopsy. We have established an approach for measuring patient-specific circulating and cell concordance by introducing tumor touch preparations High-Definition Single Cell Analysis workflow high-resolution cytomorphometric characterization of metastatic colorectal...
Abstract Background There is no agreed upon standard of care for borderline‐resectable pancreatic cancer (BRPC) or locally‐advanced (LAPC) patients regarding the benefit chemotherapy radiation alone in combination. Patients and Methods We completed a retrospective cohort analysis BRPC LAPC at center with expertise multi‐disciplinary ductal adenocarcinoma (PDAC) treatment over 5‐year period from 03/01/2014 to 03/01/2019 (cut‐off date). The total evaluable newly diagnosed, naïve, BRPC,...