A5089787461- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Cutaneous Melanoma Detection and Management
- HER2/EGFR in Cancer Research
- Urological Disorders and Treatments
- Breast Implant and Reconstruction
- Venous Thromboembolism Diagnosis and Management
- Lymphatic System and Diseases
- Genital Health and Disease
- Abdominal Trauma and Injuries
- Cancer Genomics and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Sarcoma Diagnosis and Treatment
- Trauma and Emergency Care Studies
- Vascular Tumors and Angiosarcomas
- Vascular anomalies and interventions
- Cardiac Arrhythmias and Treatments
- Urologic and reproductive health conditions
- Cancer and Skin Lesions
- Cancer Treatment and Pharmacology
- Melanoma and MAPK Pathways
- Pelvic and Acetabular Injuries
- LGBTQ Health, Identity, and Policy
- Infrared Thermography in Medicine
- Trauma Management and Diagnosis
Australian National University
2021-2025
Sydney Adventist Hospital
2014-2025
University of Manchester
2024
Charing Cross Hospital
2024
Manchester Academic Health Science Centre
2024
Northern Sydney Local Health District
2022-2023
Queen's University Belfast
2022
The University of Sydney
1999-2021
Cancer Council Australia
2021
Melanoma Institute Australia
2011-2021
To assess the frequency and type of oncogenic BRAF mutations in metastatic melanoma correlate status with clinicopathologic features outcome.Consecutive BRAF-tested Australian patients (n = 197) were observed prospectively. A comprehensive range variables correlated mutation status, a survival analysis was conducted.Forty-eight percent had mutation; 70 (74%) V600E, 19 (20%) V600K, six (6%) other genotypes. Other than age at diagnosis distant metastasis (median age, 56 v 63 years for...
Background: This study compared rates of progression to chronic breast cancer-related lymphedema (defined as ≥ 10% arm volume change from baseline requiring complex decongestive physiotherapy [CDP]) following an intervention for subclinical (S-BCRL) triggered by bioimpedance spectroscopy (BIS) or tape measurement (TM). Methods and Results: stratified, randomized, international trial enrolled new cancer patients undergoing: mastectomy/partial mastectomy, axillary treatment (dissection,...
Merkel cell carcinoma is an aggressive primary cutaneous neuroendocrine carcinoma. Patients remain at high risk of locoregional and distant relapse despite treatment. Most studies support the incorporation adjuvant radiotherapy in reducing relapse.Between 1980 2002, 86 patients diagnosed with were treated curative intent Westmead Hospital, Sydney. Multivariate analysis was performed using Cox regression analysis. Disease-free survival overall calculated Kaplan-Meier curves.Median age...
Electroporation therapy (EPT) is a novel treatment modality that uses brief, high-intensity, pulsed electrical currents to enhance the uptake of chemotherapeutic agents, vaccines and genes into cells. This technique potentially useful for patients with secondary and, possibly, some primary tumours. Nineteen metastatic melanoma were enrolled in phase two, randomized, open-label study comparing intralesional bleomycin+EPT bleomycin alone. Of 18 lesions, 13 (72%) showed complete response, one...
Background To evaluate risk factors (treatment‐related, comorbidities, and lifestyle) for breast cancer–related lymphedema (BCRL) within the context of a Prospective Surveillance Early Intervention (PSEI) model care subclinical BCRL. Methods The parent randomized clinical trial assigned patients newly diagnosed with cancer to PSEI either bioimpedance spectroscopy (BIS) or tape measurement (TM). Surgical, systemic radiation treatments, lifestyle were recorded. Detection BCRL (change from...
Abstract Background The appropriate management of melanoma metastatic to inguinal lymph nodes remains controversial. aim this study was identify disease- and treatment-related factors that influence the outcome patients undergoing therapeutic groin dissection for clinically detectable node metastases. Methods A retrospective analysis performed on data collected from case records who had a between 1984 1998. Results Some 132 were suitable inclusion. Sixty superficial (SLND) 72 combined pelvic...
In Brief Background: Accurate reporting of prognostically important histopathologic parameters is critical for optimal management melanoma patients. Previous studies have shown that assessment Breslow thickness and ulceration more reproducible between pathologists than estimation Clark level. However, detailed quantification the magnitude variation observers its effect on staging has not been reported. Methods: Nine hundred twelve patients referred to Sydney Melanoma Unit (SMU) with...
Abstract Background The clinical management of the axilla in early breast cancer has changed since Z0011 trial, which showed that axillary lymph node dissection (ALND) is not necessary select patients with a positive sentinel biopsy (SLNB). Studies have shown significant decrease rates completion ALND (cALND) Z0011. aims this study were to investigate effect trial on nodes and trends surgical 2005 Australia New Zealand. Methods This utilized prospectively maintained data from BreastSurgANZ...
The molecular chaperone Heat shock protein 90 (Hsp90) is essential for the folding, stability, and activity of several drivers oncogenesis. Hsp90 inhibitors are currently under clinical evaluation cancer treatment, however their efficacy limited by lack biomarkers to optimize patient selection. We have recently identified tumor suppressor tuberous sclerosis complex 1 (Tsc1) as a new co-chaperone that affects binding its inhibitors. Highly variable mutations TSC1 been previously in bladder...