A5082160146- HIV-related health complications and treatments
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Epigenetics and DNA Methylation
- HIV, Drug Use, Sexual Risk
- Alcohol Consumption and Health Effects
- Pneumocystis jirovecii pneumonia detection and treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cannabis and Cannabinoid Research
- Substance Abuse Treatment and Outcomes
- Lipoproteins and Cardiovascular Health
- Primary Care and Health Outcomes
- Diversity and Career in Medicine
- Tryptophan and brain disorders
- Liver Disease and Transplantation
- Viral Infections and Immunology Research
- Resilience and Mental Health
- Cardiovascular Disease and Adiposity
- Cardiovascular Function and Risk Factors
- Food Security and Health in Diverse Populations
- Health disparities and outcomes
- Folate and B Vitamins Research
- Hepatitis B Virus Studies
Boston University
2016-2025
Boston Medical Center
2015-2025
Stadtwerke Dinslaken (Germany)
2024
University School
2022-2023
VA Greater Los Angeles Healthcare System
2015-2021
University of California, Los Angeles
2021
Maricopa County Department of Public Health
2020
Vanderbilt University Medical Center
2015-2019
Emory University
2015-2019
Korea Advertising Society
2015-2018
Importance: Whether people infected with human immunodeficiency virus (HIV) are at an increased risk of acute myocardial infarction (AMI) compared uninfected is not clear.Without demographically and behaviorally similar comparators without uniformly measured clinical data on factors fatal nonfatal AMI events, any potential association between HIV status may be confounded.Objective: To investigate whether associated after adjustment for all standard Framingham among a large cohort...
With improved survival, heart failure (HF) has become a major complication for individuals with human immunodeficiency virus (HIV) infection. It is unclear if this risk extends to different types of HF in the antiretroviral therapy (ART) era. Determining whether HIV infection associated reduced ejection fraction (HFrEF), preserved (HFpEF), or both critical because differ respect underlying mechanism, treatment, and prognosis.To investigate increases future HFrEF HFpEF assess varies by...
Background.Biomarkers of inflammation, altered coagulation, and monocyte activation are associated with mortality cardiovascular disease (CVD) in the general population among human immunodeficiency virus (HIV)-infected people.We compared biomarkers for between HIV-infected uninfected people Veterans Aging Cohort Study (VACS).Methods.Biomarkers inflammation (interleukin-6 [IL-6]), coagulation (D-dimer), (soluble CD14 [sCD14]) were measured blood samples from 1525 843 VACS...
Traditional cardiovascular disease risk factors (CVDRFs) increase the of acute myocardial infarction (AMI) among HIV-infected (HIV+) participants. We assessed association between HIV and incident AMI within CVDRF strata.Cohort-81,322 participants (33% HIV+) without prevalent CVD from Veterans Aging Cohort Study Virtual (prospective study HIV+ matched HIV- veterans) participated in this study. were followed first clinical encounter on/after April 1, 2003, until AMI/death/last follow-up date...
<h3>Objective:</h3> Given conflicting data regarding the association of HIV infection and ischemic stroke risk, we sought to determine whether conferred an increased risk among male veterans. <h3>Methods:</h3> The Veterans Aging Cohort Study–Virtual consists HIV-infected uninfected veterans in care matched (1:2) for age, sex, race/ethnicity, clinical site. We analyzed on 76,835 participants who were free baseline cardiovascular disease. assessed demographics, factors, comorbid diseases,...
Background HIV infection is associated with increased risk of cardiovascular disease ( CVD ) in men. Whether an independent factor for women has not yet been established. Methods and Results We analyzed data from the Veterans Aging Cohort Study on 2187 (32% infected [ + ]) who were free at baseline. Participants followed their first clinical encounter or after April 01, 2003 until a event, death, last follow‐up date (December 31, 2009). The primary outcome was (acute myocardial infarction...
Compared to uninfected people, human immunodeficiency virus (HIV)-infected individuals may have an increased risk of acute myocardial infarction (AMI). Currently, HIV-infected people are treated the same blood pressure (BP) goals (<140/90 or <130/80 mm Hg) as their counterparts. Whether with elevated BP excess AMI compared is not known. This study examines whether association between and differs by HIV status.The Veterans Aging Cohort Study Virtual (VACS VC) consists -uninfected veterans...
Background: HIV infection and biomarkers of inflammation [measured by interleukin-6 (IL-6)], monocyte activation [soluble CD14 (sCD14)], coagulation (D-dimer) are associated with morbidity mortality. We hypothesized that these immunologic processes mediate (explain) some the excess risk mortality among infected (HIV+) versus uninfected people independently comorbid diseases. Methods: Among 2350 (1521 HIV+) participants from Veterans Aging Cohort Study Biomarker (VACS BC), we investigated...
The effect of human immunodeficiency virus (HIV) on the development peripheral artery disease (PAD) remains unclear. We investigated whether HIV infection is associated with an increased risk PAD after adjustment for traditional atherosclerotic factors in a large cohort HIV-infected (HIV+) and demographically similar HIV-uninfected veterans.We studied participants Veterans Aging Cohort Study from April 1, 2003 through December 31, 2014. excluded known prior or prevalent cardiovascular...
Bilirubin may protect against cardiovascular disease (CVD) by reducing oxidative stress. Whether elevated bilirubin reduces the risk of CVD events among HIV+ individuals and if this differs from uninfected remain unclear. We assessed whether independently predicted participants in VACS (Veterans Aging Cohort Study).We conducted a prospective cohort study using free baseline CVD. Total was categorized quartiles. as well acute myocardial infarction, heart failure, ischemic stroke were...
Abstract Telomere length (TL) is an important indicator of cellular aging. Shorter TL associated with several age‐related diseases including coronary heart disease, failure, diabetes, osteoporosis, and cancer. Recently, a DNA methylation‐based (DNAmTL) estimator has been developed as alternative method for directly measuring TL. In this study, we examined the association DNAmTL cancer prevalence mortality risk among people without HIV in Veterans Aging Cohort Study Biomarker (VACS, N = 1917)...
Background— Both HIV and depression are associated with increased heart failure (HF) risk. Depression, a common comorbidity, may further increase the risk of HF among adults infection (HIV+). We assessed association between HIV, depression, incident HF. Methods Results— Veterans Aging Cohort Study (VACS) participants free from cardiovascular disease at baseline (n=81 427: 26 908 HIV+, 54 519 without [HIV−]) were categorized into 4 groups: HIV− major depressive disorder (MDD) [reference],...
The mechanism underlying the excess risk of non-AIDS diseases among HIV infected people is unclear. associated inflammation/hypercoagulability likely plays a role. While antiretroviral therapy (ART) may return this process to pre-HIV levels, has not been directly demonstrated. We analyzed data/specimens on 249 HIV+ participants from US Military Natural History Study, prospective, multicenter observational cohort >5600 active duty military personnel and beneficiaries living with HIV. used...
With the advent of highly effective antiretroviral therapy and improved survival, human immunodeficiency virus (HIV)-infected people are living longer now at an increased risk for cardiovascular disease (CVD). There is urgent need to identify novel factors primary prevention approaches CVD in HIV. Although depression prevalent HIV-infected adults associated with future general population, its association events has not been examined population.
Objectives The contribution of depression to mortality in adults with and without HIV infection is unclear. We hypothesized that increases risk this association stronger among those infection. Methods Veterans Aging Cohort Study (VACS) data were analysed from the first clinic visit on or after 1 April 2003 (baseline) 30 September 2015. Depression definitions were: (1) major depressive disorder defined using International Classification Diseases, Ninth Revision (ICD‐9) codes; (2) symptoms as...
Lower CD4+ cell count in people with HIV infection (PWH) is associated increased cardiovascular disease (CVD) risk. Whether subsets of T helper cells are linked CVD unclear. The aim this study was to explore the association between peripherally circulating and incident CVD. Data from 1,860 participants (1,270 PWH) without prevalent VACS (Veterans Aging Cohort Study), a prospective, observational cohort veterans infection, were analyzed. quantified baseline samples using flow cytometry....
Liver fibrosis is common, particularly in individuals who are infected with human immunodeficiency virus (HIV). HIV-infected have excess congestive heart failure (CHF) risk compared uninfected people. It remains unknown whether liver stage influences the CHF or if HIV hepatitis C (HCV) infection modifies this association. Our objectives were to assess 1) of independently associated incident and 2) association between modified by HIV/HCV status. Participants alive on after April 1, 2003,...
The epidemiology and prognostic impact of increased pulmonary pressure among HIV-infected individuals in the antiretroviral therapy era is not well described.To examine prevalence, clinical features, outcomes echocardiographic -uninfected individuals.This study evaluated 8,296 veterans referred for echocardiography with reported artery systolic (PASP) estimates from Veterans Aging Cohort study, an observational cohort matched by age, sex, race/ethnicity, site. primary outcome was adjusted...