A5005215250- Pancreatic and Hepatic Oncology Research
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- Immunotherapy and Immune Responses
- Nanoparticle-Based Drug Delivery
- Cancer Research and Treatments
- Advanced biosensing and bioanalysis techniques
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- Colorectal Cancer Treatments and Studies
- Cancer-related Molecular Pathways
- PI3K/AKT/mTOR signaling in cancer
- RNA Interference and Gene Delivery
- Circular RNAs in diseases
- Cytokine Signaling Pathways and Interactions
- DNA Repair Mechanisms
- Cancer, Hypoxia, and Metabolism
- Genomics, phytochemicals, and oxidative stress
- Phagocytosis and Immune Regulation
- Nicotinic Acetylcholine Receptors Study
- Lipid metabolism and disorders
Henry Ford Health System
2024-2025
Emory University
2018-2024
Albert Einstein College of Medicine
2022-2023
The Barbara Ann Karmanos Cancer Institute
2018-2019
Wayne State University
2018-2019
Emory Healthcare
2019
Institute of Structural and Molecular Biology
2017
University College London
2017
Background Preclinical studies showed metformin reduces exhaustion of tumor-infiltrating lymphocytes and potentiates programmed cell death protein-1 (PD-1) blockade. We hypothesized that with nivolumab would elicit potent antitumor immune modulatory activity in metastatic microsatellite stable (MSS) colorectal cancer (CRC). evaluated this hypothesis a phase II study. Methods Nivolumab (480 mg) was administered intravenously every 4 weeks while (1000 given orally, two times per day following...
Gastric cancer (GC) remains the third leading cause of cancer-related death despite several improvements in targeted therapy. There is therefore an urgent need to investigate new treatment strategies, including identification novel biomarkers for patient stratification. In this study, we evaluated effect FDA-approved kinase inhibitors on GC. Through a combination cell growth, migration and invasion assays, identified dasatinib as efficient inhibitor GC proliferation. Mass-spectrometry-based...
Abstract Prostate cancer is one of the most common cancers in men worldwide. Currently available diagnostic and prognostic tools for this disease, such as prostate specific antigen, suffer from lack specificity sensitivity, resulting over- misdiagnosis. Hence, there an urgent need clinically relevant biomarkers capable distinguishing between aggressive nonaggressive forms to aid stratification, management therapeutic decisions. To address unmet need, we investigated patterns expression a...
Abstract Introduction: Triple negative breast cancer (TNBC) among women with African ancestry has been shown to be more prevalent than in of European ancestry. However, the root cause for this disparity is not fully understood. We have previously that gene expression stem cells TNBC tumors differs based on Western sub-Saharan Tumor organoids are three-dimensional structures derived from tumor and able mimic organization function organ origin. Organoids are, therefore, valuable tools studying...
Abstract Triple negative breast cancer (TNBC) is the most aggressive form of cancer. It highly prevalent in women West Sub-Saharan African ancestry (WSSA) and American (AA) women, resulting poorer survival outcomes compared to European (EA) women. Studies have shown that immune cells tumor microenvironment (TME) contribute progression TNBC by suppression, reprogramming macrophages into pro-tumorigenic subtypes release inflammatory cytokines. A previous study our laboratory revealed processes...
Background The induction of reactive oxygen species (ROS) represents a viable strategy for enhancing the activity radiotherapy. authors hypothesized that napabucasin would increase ROS via its ability to inhibit NAD(P)H:quinone oxidoreductase 1 and potentiate response chemoradiotherapy in rectal cancer distinct mechanisms. Method Proliferation studies, colony formation assays, levels were measured HCT116 HT29 cell lines treated with napabucasin, chemoradiation, or their combination. DNA...