A5035064117- Cardiac electrophysiology and arrhythmias
- Nonlinear Dynamics and Pattern Formation
- Ion channel regulation and function
- stochastic dynamics and bifurcation
- Cosmology and Gravitation Theories
- Dark Matter and Cosmic Phenomena
- Neural dynamics and brain function
- Industrial Technology and Control Systems
- Neuroscience and Neural Engineering
- Advanced Sensor and Control Systems
- Hydraulic and Pneumatic Systems
- Hydraulic Fracturing and Reservoir Analysis
- Drilling and Well Engineering
- Astronomy and Astrophysical Research
- Simulation and Modeling Applications
- Acute Ischemic Stroke Management
- Gene Regulatory Network Analysis
- Pancreatitis Pathology and Treatment
- Advanced Algorithms and Applications
- Turbomachinery Performance and Optimization
- ECG Monitoring and Analysis
- Cardiac Arrhythmias and Treatments
- Extracellular vesicles in disease
- Atrial Fibrillation Management and Outcomes
- Blood Pressure and Hypertension Studies
Southeast University
2024
First Affiliated Hospital of Xiamen University
2023-2024
Xiamen University
2024
South China University of Technology
2009-2024
Fujian Medical University
2024
First Affiliated Hospital of Fujian Medical University
2024
Huizhou Central People's Hospital
2010-2023
Guang’anmen Hospital
2023
China National Offshore Oil Corporation (China)
2007-2019
University of California, Los Angeles
2009-2018
Small-world networks describe many important practical systems among which neural consisting of excitable nodes are the most typical ones. In this paper we study self-sustained oscillations target waves in small-world networks. A dominant phase-advanced driving (DPAD) method, is generally applicable for analyzing all oscillatory complex nonoscillatory nodes, proposed to reveal self-organized structures supporting type oscillations. The DPAD method explicitly explores oscillation sources and...
Key points T‐wave alternans (TWA) and lability (TWL) are precursors of ventricular arrhythmias in long QT syndrome; however, the mechanistic link remains to be clarified. Computer simulations show that action potential duration (APD) prolongation slowed heart rates promote APD chaos, manifesting as TWA TWL, respectively. Regional chaos can exacerbate pre‐existing or induce de novo dispersion, which combines with enhanced I Ca,L result premature complexes (PVCs) originating from gradient...
The occurrence of early afterdepolarizations (EADs) and increased dispersion repolarization are two known factors for arrhythmogenesis in long QT syndrome. However, tends to suppress EADs due the source-sink effect, thus how competing cause initiation arrhythmias remains incompletely understood. Here we used optical mapping computer simulation investigate mechanisms underlying spontaneous type 2 (LQT2) In experiments transgenic LQT2 rabbit hearts under isoproterenol, premature ventricular...
Early afterdepolarizations (EADs) are abnormal depolarizations during the plateau phase of action potential, which known to be associated with lethal arrhythmias in heart. There two major hypotheses for EAD genesis based on experimental observations, i.e., voltage ( V m )-driven and intracellular calcium (Ca)-driven mechanisms. In ventricular myocytes, Ca bidirectionally coupled, can affect each other’s dynamics result new dynamics, however, roles cycling its coupling EADs have not been well...
Early afterdepolarizations (EADs) are spontaneous depolarizations during the repolarization phase of an action potential in cardiac myocytes. It is widely known that EADs promoted by increasing inward currents and/or decreasing outward currents, a condition called reduced reserve. Recent studies based on bifurcation theories show caused dual Hopf-homoclinic bifurcation, bringing further mechanistic insights into genesis and dynamics EADs. In this study, we investigated EAD properties, such...
Diverse self-sustained oscillatory patterns and their mechanisms in small-world networks (SWNs) of excitable nodes are studied. Spatiotemporal SWNs sensitive to long-range connection probability $P$ coupling intensity $D$. By varying wide range with fixed $D$, we observe totally six types asymptotic states: pure spiral waves, target mixtured spirals pseudospiral turbulence, synchronizing oscillations, rest state. The parameter conditions for all these states specified, the heuristically...
Phase-locking behaviors in sinoatrial node (SAN) are closely related to cardiac arrhythmias. An ionic model considering structural heterogeneity of SAN is numerically investigated. The bifurcations between phase-locking zones interpreted by the map derived from phase resetting curve. Furthermore, validity circle describing locking actual system evaluated and explained. We reveal also how heterogeneous tissue depend on location stimulating site coupling strength tissue. All these results may...
Hysteresis in periodically paced cardiac tissue is an important issue due to its relevance arrhythmias. In the present paper, mechanism of hysteresis formation and related properties are interpreted by numerically investigating phase I Luo-Rudy model. A formula calculating width proposed well confirmed numerical simulations. We also find that shows several characteristics couplings among cells which absent a single cell. The influences physiological parameters studied detail. model...
Information storage in many functional subsystems of the brain is regarded by theoretical neuroscientists to be related attractors neural networks. The number large and each attractor can temporarily represented or suppressed easily corresponding external stimulus. In this letter, we discover that complex networks consisting excitable nodes have similar fascinating properties coexistence numbers oscillatory attractors, most which labeled with a few nodes. According simple labeling rule,...
Background: The increasingly younger age of stroke onset has posed a serious threat to the physical and mental health young middle-aged adults. Young patients often suffer from varying degrees motor, cognitive, language disabilities, which can trigger considerable psychological trauma. However, these may have certain posttraumatic growth (PTG). As positive experience, PTG provides new entry point for clinical interventions. Here, we explored trajectories in their predictive effects on...
Despite the exciting progress of bifunctional degrader molecules, also known as proteolysis-targeting chimeras (PROTACs), rapidly expanding field is still significantly hampered by lacking available E3 ligase ligands. Our research bridges this gap uncovering a series small-molecule ligands to TRIM21 through DNA-Encoded Library (DEL) technology. We confirmed their interaction with using crystallography and demonstrated anti-proliferative effects across various cancer cell types. Furthermore,...
This paper investigates antispiral wave breakup phenomena in coupled two-dimensional FitzHugh–Nagumo cells with self-sustained oscillation via Hopf bifurcation. When the coupling strength of active variable decreases to a critical value, phenomenon first occurs core region where waves collide each other and spontaneously break into spatiotemporal turbulence. Measurements reveal for time that this is due mechanism Doppler instability.
Sinus node arrest is a dangerous disease, which associated with the annihilation of cardiac biological oscillators. The present work investigates in detail pacemaking modeled single SAN cell and heterogeneous tissue by conventional nonlinear dynamics approach. It found that should generally exist system, due to subcritical Hopf bifurcation. However, strict stimulus physiological parameters, for difficulty estimated. Intracellular calcium cycling makes more robust against annihilation....
Ventricular arrhythmias are the leading cause of sudden cardiac death. Understanding mechanisms arrhythmia initiation is important for developing effective therapeutics prevention. Arrhythmias can be induced via premature external stimuli or occur spontaneously dynamical instabilities. Computer simulations have shown that a large repolarization gradient due to regional prolongation action potential duration result in instabilities excitations and arrhythmias, but bifurcation remains...
The sinoatrial node (SAN)-atrium system is closely involved with the activity of heart beating. impulse propagation and phase-locking behaviors this are theoretical interest. Some experiments have revealed that atrial strands (ASs) interdigitate penetrate into SAN, whereby SAN-atrium works as a complex network. In study, functions ASs numerically investigated using realistic cardiac models. results indicate penetrating central region SAN play major role in propagating excitation atrium. This...
Early afterdepolarization (EAD) is a major arrhythmogenic factor in the long QT syndrome (LQTS), whose conditions for genesis have puzzled people several decades. Here, we employ phase I Luo–Rudy ventricular myocyte model to investigate EAD using methods from nonlinear dynamics and provide valuable insights into physical perspective. Two results are obtained: (i) Sufficient parametric analytically determined then used analyze detail effects of physiological parameters. (ii) The normal form...
Abstract Wave propagation is an important characteristic for pattern formation and dynamics. To date, various waves in homogeneous media have been investigated extensively understood to a great extent. However, the wave behaviors heterogeneous studied much less. In this work, we investigate that are spontaneously generated one-dimensional oscillatory governed by complex Ginzburg-Landau equations; heterogeneity modeled multiple interacting with different system control parameters. Rich can be...
In this paper we investigate spatiotemporal pattern formation in excitable media with only a long-range link. Besides the trivial solutions of spiral patterns, find asymptotic self-sustained target waves autonomous tissues. The wave source supporting kind new is oscillatory one-dimensional Winfree-loop self-organized under presence link, which explored by dominant phase-advanced driving method. Based on understanding can effectively regulate oscillations suitably arranging including...
The control of spiral wave breakup due to Doppler instability has been investigated. It is found that by applying the spatiotemporal modulation method with suitable parameters, can be prevented. Further numerical simulations show preventing a result decrease meandering motion tip.