A5071260151- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- Lipid Membrane Structure and Behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related molecular mechanisms research
- Signaling Pathways in Disease
- Vitamin D Research Studies
- Calpain Protease Function and Regulation
- GDF15 and Related Biomarkers
- RNA Research and Splicing
- Neural dynamics and brain function
- Advanced Fluorescence Microscopy Techniques
- Zebrafish Biomedical Research Applications
- RNA modifications and cancer
University of California, San Francisco
2025
University of Science and Technology of China
2022-2024
Hefei National Center for Physical Sciences at Nanoscale
2022-2024
Chinese Academy of Sciences
2022
Anhui Medical University
2022
Cancer Hospital of Chinese Academy of Medical Sciences
2022
The subsynaptic organization of postsynaptic neurotransmitter receptors into nanoclusters that are aligned with presynaptic release sites is essential for the high fidelity synaptic transmission. However, mechanisms controlling nanoscale in vivo remain incompletely understood. Here, we deconstructed role neuroligin-3 (Nlgn3), a adhesion molecule linked to autism, organizing AMPA-type glutamate calyx Held synapse. Deletion
Recent evidence has demonstrated that the transsynaptic nanoscale organization of synaptic proteins plays a crucial role in regulating strength excitatory synapses. However, molecular mechanism underlying this nanostructure inhibitory synapses still remains unclear and its impact on synapse function physiological or pathological contexts not been demonstrated. In study, we utilized an engineered proteolysis technique to investigate effects acute cleavage neuroligin-2 (NL2) transmission. Our...
Maintaining a dynamic neuronal synapse pool is critical to brain development. The extracellular matrix (ECM) regulates synaptic plasticity via mechanisms that are still being defined and studied predominantly in adulthood. Using live imaging of excitatory synapses zebrafish hindbrain we observed bimodal distribution short-lived (dynamic) longer-lived (stable) synapses. Disruption ECM digestion or brevican deletion destabilized but not stable led decreased density. Conversely, loss...
Nanoscale organization of presynaptic proteins determines the sites transmitter release, and its alignment with assemblies postsynaptic receptors through nanocolumns is suggested to optimize efficiency synaptic transmission. However, it remains unknown how these nano-organizations are formed during development. In this study, we used super-resolution stochastic optical reconstruction microscopy (STORM) imaging technique systematically analyze evolvement subsynaptic three key proteins,...
Background: Increasing evidence indicates that vitamin D deficiency negatively affects the cardiovascular system. Here we studied therapeutic effects of calcitriol in myocardial infarction (MI) and investigated its underlying mechanisms. Methods: A MI model Kun-ming mice induced by left anterior descending coronary artery ligation was utilized to study potential on MI. AC16 human cardiomyocyte-like cells treated with TNF-α were used for exploring mechanisms underlie cardioprotective...