A5100748903- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Receptor Mechanisms and Signaling
- Neuroscience and Neural Engineering
- Lipid Membrane Structure and Behavior
- Advanced Memory and Neural Computing
- Nerve Injury and Rehabilitation
- Stress Responses and Cortisol
- BRCA gene mutations in cancer
- Machine Learning in Bioinformatics
- Breast Cancer Treatment Studies
- Neural Networks and Applications
- Nutrition, Genetics, and Disease
- Tendon Structure and Treatment
- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Barrier Structure and Function Studies
- Neurological Disorders and Treatments
- Electrochemical Analysis and Applications
- Nerve injury and regeneration
- Anesthesia and Neurotoxicity Research
- Gut microbiota and health
- Intensive Care Unit Cognitive Disorders
University of California, San Diego
2020-2024
Zhengzhou University
2024
First Affiliated Hospital of Xi'an Jiaotong University
2021
Academy of Military Medical Sciences
2021
Chongqing Medical University
2020
Biogen (United States)
2019
Qingdao University
2017
Qingdao Municipal Hospital
2017
Southern Medical University
2014
National Institutes of Health
2008-2013
Footshock stress can reinstate cocaine-seeking behavior through a central action of the stress-associated neurohormone corticotropin-releasing factor (CRF). Here we report (1) that footshock releases CRF in ventral tegmental area (VTA) rat brain, (2) that, cocaine-experienced but not cocaine-naive rats, this acquires control over local glutamate release, (3) CRF-induced release activates mesocorticolimbic dopamine system, and (4) circuitry, triggers relapse to drug seeking animals. Thus,...
Intravenous injections of cocaine HCl are habit-forming because, among their many actions, they elevate extracellular dopamine levels in the terminal fields mesocorticolimbic system. This action, thought to be very important for cocaine's strong addiction liability, is believed have short latency and assumed reflect rapid brain entry pharmacokinetics drug. However, while intravenous has almost immediate effects on behavior levels, recent evidence suggests that its central pharmacological not...
Neurotrophin-3 (NT3) is an important neurotrophic factor for spinal cord injury (SCI) repair. However, constant exchange of cerebrospinal fluid often decreases the effective dosage NT3 at targeted site. In present study, a recombinant collagen-binding (CBD-NT3), consisting domain (CBD) and native NT3, was constructed. Linear rat-tail collagen (LRTC) used as physical carrier CBD-NT3 to construct LRTC/C3 system. The ability verified, bioactivity assayed with neurite outgrowth dorsal root...
Background: Postoperative Cognitive Dysfunction (POCD) has received considerable attention as one of the main postoperative complications. The underlying mechanism POCD in elderly subjects not been fully elucidated to date. Central Nervous System (CNS) is isolated from bloodstream by Blood Brain Barrier (BBB) that consists endothelial cells, capillary blood vessels and tight junctions. junctions carry out significant biological functions are associated with CNS circulation. Methods: In this...
Recent evidence has demonstrated that the transsynaptic nanoscale organization of synaptic proteins plays a crucial role in regulating strength excitatory synapses. However, molecular mechanism underlying this nanostructure inhibitory synapses still remains unclear and its impact on synapse function physiological or pathological contexts not been demonstrated. In study, we utilized an engineered proteolysis technique to investigate effects acute cleavage neuroligin-2 (NL2) transmission. Our...
Enhancing remyelination is a key therapeutic strategy for demyelinating diseases such as multiple sclerosis. To achieve this goal, central challenge being able to quantitatively and longitudinally track functional remyelination, especially with translatable biomarkers that can be performed in both preclinical models the clinic. We developed methodology stably measure multi-modal sensory evoked potentials from skull surface over course of months individual mice applied it genetic mouse model...
Rapid and precise neuronal communication is enabled through a highly synchronous release of signaling molecules neurotransmitters within just milliseconds the action potential. Yet neurotransmitter lacks theoretical framework that both phenomenologically accurate mechanistically realistic. Here, we present an analytic theory action-potential-triggered at chemical synapse. The demonstrated to be in detailed quantitative agreement with existing data on wide variety synapses from...
While glutamate in the nucleus accumbens (NAS) contributes to promotion of drug-seeking by drug-predictive cues, it also appears play a role inhibition following extinction procedures. Thus we measured extracellular fluctuations NAS response discriminative stimuli that signaled either cocaine availability or omission. We trained rats self-administer intravenous and then recognize odor cues predicted sessions where was available alternating not (saline substituted for cocaine). Whereas...
Fluctuations of synaptic weights, among many other physical, biological, and ecological quantities, are driven by coincident events two "parent" processes. We propose a multiplicative shot-noise model that can capture the behaviors broad range such natural phenomena, analytically derive an approximation accurately predicts its statistics. apply our results to study effects plasticity rule was recently extracted from measurements in physiological conditions. Using mean-field theory analysis...
Abstract Neural circuits construct internal ‘world-models’ to guide behavior. The predictive processing framework posits that neural activity signaling sensory predictions and concurrently computing prediction-errors is a signature of those models. Here, understand how the brain generates for complex sensorimotor signals, we investigate emergence high-dimensional, multi-modal representations in recurrent networks. We find robust arises network with loose excitatory/inhibitory balance....
Background: The role of surgery and type in de novo stage IV breast cancer (BC) is unclear. Methods: We carried out a retrospective cohort study that included the data 4,108 individuals with BC abstracted from SEER (Surveillance, Epidemiology, End Results) resource 2010 to 2015. patients were stratified into non-surgery group, breast-conserving (BCS) mastectomy group. Inverse probability propensity score weighting (IPTW) was then used balance clinicopathologic factors. Overall survival (OS),...
Abstract Rapid and precise neuronal communication is enabled through a highly synchronous release of signaling molecules neurotransmitters into the synaptic cleft within just milliseconds action potential. Yet neurotransmitter lacks theoretical framework that both phenomenologically accurate mechanistically realistic. Here, we formulate an analytic theory action-potential-triggered at chemical synapse. The captures general principles transmission while generating concrete predictions for...
Objective To investigate the changes in expression of hippocampal occludin and claudin-5 after operation aged rats. Methods Eighty-one healthy male Wistar rats, 16–18 months, weighing 400–500 g, were randomly assigned into 3 groups(n=27 each)using a random number table: normal control group(group C), skin incision I)and splenectomy S). Splenectomy was performed group S. Only closing I. Morris water maze test before on 1, 7 days operation.The escape latency percentage time spent at...