A5004983925- Gastric Cancer Management and Outcomes
- Head and Neck Cancer Studies
- Metastasis and carcinoma case studies
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Research Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Viral-associated cancers and disorders
- RNA modifications and cancer
- Gastrointestinal Tumor Research and Treatment
- Bladder and Urothelial Cancer Treatments
- Cancer Research and Treatments
- Prostate Cancer Treatment and Research
- Advanced Breast Cancer Therapies
- Esophageal and GI Pathology
- Fibroblast Growth Factor Research
- Neuroendocrine Tumor Research Advances
- Cancer Cells and Metastasis
- Hepatitis C virus research
- Virus-based gene therapy research
- melanin and skin pigmentation
- Dermatologic Treatments and Research
- Wnt/β-catenin signaling in development and cancer
Chang Gung University
2015-2025
Chang Gung Memorial Hospital
2015-2025
Linkou Chang Gung Memorial Hospital
2014-2024
Taipei City Hospital
2021-2022
Eastern Cooperative Oncology Group
2015
Creative Commons
2015
Memorial Hospital
2015
Chiayi Chang Gung Memorial Hospital
2015
Keelung Chang Gung Memorial Hospital
2015
PURPOSE: This study assessed the impact of navify Tumor Board digital tool on multidisciplinary team tumor boards’ (MDTs) efficiency, comparing its streamlined workflow and preparation to conventional, time-consuming methods. METHODS: prospective observational (January–June 2021) compared MDT phase durations (preparation, discussion, follow-up) using platform versus conventional methods for integrated patient data management decision-making. RESULTS: The significantly improved efficiency...
Background: Stage III gastric cancer is characterized by locally advanced disease with varying anatomic extent as measured the 7 th edition of American Joint Committee on Cancer (AJCC) staging system.There are no prognostic factors specifically identified in patients stage following extended lymph node dissection (D2) surgery.Materials and Methods: From 2007 to 2014, 534 underwent radical gastrectomy D2 at Chang Gung Memorial Hospital.Patients' characteristics impact adjuvant chemotherapy...
This study aimed at investigating the ability of a preoperative Glasgow prognostic score (GPS) to predict postoperative complications and survival outcomes in patients with stage III gastric cancer undergoing D2 gastrectomy. We retrospectively reviewed data from 272 such patients, treated between 2010 2016, Taiwanese medical center. The were categorized according their GPS. In total, 36.8%, 48.5%, 14.7% assigned groups GPS 0, 1, 2, respectively. Overall surgical complication rates these 30%,...
Determining the survival outcome for gastric cancer patients with metastases to more than 15 regional lymph nodes is difficult. This study aims develop a node metastatic ratio (LNR)-based prognostic model predict after D2 surgery in such patient groups. Our retrospectively enrolled 139 who underwent between 2007 and 2014. Clinicopathologic variables overall (OS) using multivariate Cox regression were selected create model. The predicting OS was developed based on five independent factors,...
// Cheng-Lung Hsu 1 , Yung-Chia Kuo Yenlin Huang 2 Yin-Cheng 3 Kar-Wai Lui 4 Kai-Ping Chang 5 Tung-Liang Lin Hsien-Chi Fan An-Chi Chia-Hsun Hsieh Li-Yu Lee Hung-Ming Wang Hsin-Pai Li 6 Yu-Sun Division of Hematology-Oncology, Department Internal Medicine, Gung Memorial Hospital, University, Taoyuan 333, Taiwan, ROC Pathology, Neurologic Surgery, Medical Imaging and Intervention, Otolaryngology-Head Neck Cell Molecular Biology, Correspondence to: Hsu, e-mail: hsu2221@adm.cgmh.org.tw Keywords:...
A previous study demonstrated that cytokeratin 19 (CK19) expression in hepatocellular carcinoma (HCC) is an indicator of HCC invasiveness, including lymph node metastasis (LNM), tumor infiltration/non-encapsulation and poor prognosis. The exact mechanism by which CK19 results prognosis remains unclear. Through the use Affymetrix U133A oligonucleotide microarray [20 patients with hepatitis B virus (HBV)-HCC], it was cadherin 17 (CDH17) significantly correlated (R2, 0.867; P<0.001) HBV-HCC....
Liver resection is a standard treatment for hepatocellular carcinoma (HCC).The purpose of this study was to investigate the clinicopathological characteristics and long-term outcomes octogenarians with HCC treated liver resection.Records patients who underwent were reviewed, older younger than 80 years compared.There 77 age or 3,309 years.Hepatitis C virus infection most common etiology among (43.1%), followed by non-viral causes (37.5%).The group had more co-morbidity but less hepatitis B...
Differential overall survival of nasopharyngeal carcinoma (NPC) with different organ site metastases has been documented. Here, we attempted to determine the underlying mechanisms by assessing plasma and tumor tissue markers in relation patient survival. Pretreatment Epstein-Barr virus (EBV) DNA concentrations, cytokines macrophages, proliferation apoptosis were determined 178 patients metastatic NPC. The median (OS) was 19 months. Patients single had better outcomes than those multiple...
Background: Nasopharyngeal carcinoma (NPC) involves host genetics, environmental and viral factors. In clinical observations, patients of young old ages were found to have higher recurrence metastatic rates. Methods: Cytokine array was employed screen druggable target(s). The candidate target(s) confirmed through patient-derived xenografts (PDXs) a new EBV-positive cell line, NPC-B13. Results: Overexpression epithelial growth factor (EGF) EGF receptor (EGFR) detected in than older patients....
Paraneoplastic leukocytosis (PNL) in genitourinary cancer, though rare, can indicate aggressive behavior and poor outcomes. It has been potentially linked to cancer expressing G-CSF GM-CSF, along with their respective receptors, exerting an autocrine/paracrine effect. In our study, we successfully established four patient-derived xenograft (PDX) lines related cell from urothelial (UC), conducting next-generation sequencing (NGS) for genetic studies. UC-PDX-LN1, originating bladder exhibited...
Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-associated cancer, and immune checkpoint inhibitors (ICIs) have shown efficacy in its treatment. The combination of chemotherapy ICIs represents a new trend the standard care for metastatic NPC. In this study, we aim to clarify cell profile related prognostic factors ICI-based treatment Programmed death ligand 1 (PD-L1) expression was measured 81 tissue samples that had not received prior ICI combined positive score (CPS) 58.0%...
Abstract Objective Studies have rarely explored the efficacy of S‐1 in treating advanced pancreatic cancer outside Japan. This study compared survival outcomes patients with treated those without treatment before and after reimbursement was introduced Taiwan June 2014. Method We retrospectively analyzed 838 locally or metastatic who underwent palliative chemotherapy from 2010 to 2016 at 4 institutes Taiwan. For analysis, were categorized into two groups according whether they received as...
Nasopharyngeal carcinoma (NPC) is associated with Epstein-Barr virus (EBV) infection. To test preclinical NPC drugs, we established two patient-derived xenograft (PDX) mouse models, EBV-positive PDX-B13 and EBV-negative PDX-Li41, for drug screening.Based on next generation sequencing (NGS) studies, had CCND1 copy number (CN) gain but CDKN2A CN loss, whereas PDX-Li41 RB1 TSC1 (negative regulator of mTOR) frameshift deletion mutation, increased activation mTOR, a serine/threonine kinase that...
Progesterone analogues, such as megestrol acetate (MA) and medroxyprogesterone (MPA), have been used for the palliative care of cancer cachexia decades proven to increase body weight improve quality life performance status. The objective this study was determine effect progesterone analogue use on in terms pain control, status, gain, Epstein-Barr virus (EBV) DNA load recurrent/metastatic nasopharyngeal carcinoma (NPC) patients.
Carcinoma of unknown primary origin (CUP) is characterized by diverse histological subtypes and clinical presentations, ranging from clinically indolent to frankly aggressive behaviors. This study aimed identify prognostic factors CUP develop a simple risk model predict survival in cohort Asian patients.We retrospectively reviewed 190 patients diagnosed with between 2007 2012 at single medical center Taiwan. The clinicopathological parameters outcomes our were analyzed. A was developed using...
The association of non-hereditary (sporadic) gastrointestinal stromal tumors (GISTs) and second primary malignancies is known to be nonrandom, although the underlying molecular mechanisms remain unknown. In this study, 136 749 (18.1%) patients with sporadic GISTs were found have additional associated cancers, genitourinary/gynecologic/breast cancers being most prevalent. Gene mutations in their colorectal (CRCs) (n=9) analyzed using a panel 409 cancer-related genes, while separate group 40...
This is a retrospective cohort study by analyzing multi-institutional electronic medical records database in Taiwan to compare long-term effectiveness and risk of major adverse cardiac events (MACE) chemotherapy-naïve metastatic castration-resistant prostate cancer (mCRPC) patients treated with enzalutamide (ENZ) or abiraterone (AA). Patients aged 20 years older newly receiving androgen receptor targeted therapies ENZ AA from September 2016 December 2019 were included. We followed initiation...
4143 Background: The triplet regimen of S-1, leucovorin, oxaliplatin and gemcitabine (SLOG) has shown promising efficacy for metastatic pancreatic ductal adenocarcinoma (PDAC) in our previous study. Current multicenter randomized, phase II study compared the safety SLOG versus modified FOLFIRINOX (mFOLFIRINOX) patients with advanced/metastatic PDAC. Methods: Patients chemo-naïve, histologically confirmed PDAC, were randomly assigned to either (gemcitabine 800 mg/m 2 , fixed-rate infusion 85...
Decisions regarding the staging, prognosis, and treatment of patients with head neck squamous cell carcinomas (HNSCCs) are made after determining their p16 expression levels human papillomavirus (HPV) infection status. We investigated prognostic roles p16-positive p16-negative circulating tumor cells (CTCs) counts in HNSCC patients. enrolled locally advanced HNSCCs who received definitive concurrent chemoradiotherapy for final analysis. performed CTC testing analysis before...
Abstract Background Laparoscopic procedure has inherent merits of smaller incisions, better cosmesis, less postoperative pain, and earlier recovery. In the current study, we presented our method purely laparoscopic feeding jejunostomy compared its results with that conventional open approach. Methods We retrospectively reviewed patients from 2012 to 2019 who had received either (LJ, n = 29) or ones (OJ, 94) in Chang Gung Memorial Hospital, Linkou. Peri-operative data outcomes were analyzed....
Hepatitis often occurs after initiating immune checkpoint inhibitor (ICI) treatment. The time and grade of hepatitis ICI starts the prognostic role immune-related in patients with advanced hepatocellular carcinoma (aHCC) remain unclear.