A5061690739- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Virus-based gene therapy research
- Extracellular vesicles in disease
- Glioma Diagnosis and Treatment
- interferon and immune responses
- Immune cells in cancer
- Immune Cell Function and Interaction
- Nanoplatforms for cancer theranostics
- Healthcare Policy and Management
- Ga2O3 and related materials
- Neuroinflammation and Neurodegeneration Mechanisms
- Global Health Workforce Issues
- Luminescence Properties of Advanced Materials
- Protein Degradation and Inhibitors
- Nerve injury and regeneration
- Mycobacterium research and diagnosis
- Synthesis of Organic Compounds
- Viral Infections and Vectors
- Radiation Dose and Imaging
- GABA and Rice Research
- vaccines and immunoinformatics approaches
- Monoclonal and Polyclonal Antibodies Research
- Thin-Film Transistor Technologies
- Intracerebral and Subarachnoid Hemorrhage Research
Hunan University
2025
University of Alabama at Birmingham
2022-2023
Duke University
2019-2023
Beijing National Laboratory for Molecular Sciences
2020-2022
Peking University
2020-2022
Duke Medical Center
2020-2021
Peking Union Medical College Hospital
2015-2018
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2018
The targeted degradation of membrane proteins would afford an attractive and general strategy for treating various diseases that remain difficult with the current proteolysis-targeting chimera (PROTAC) methodology. We herein report a covalent nanobody-based PROTAC strategy, termed GlueTAC, protein high specificity efficiency. first established mass-spectrometry-based screening platform rapid development nanobody (GlueBody) allowed proximity-enabled cross-linking surface antigens on cancer...
Activating intra-tumor innate immunity might enhance tumor immune surveillance. Virotherapy is proposed to achieve cell killing, while indirectly activating immunity. Here, we report that recombinant poliovirus therapy primarily mediates antitumor immunotherapy via direct infection of non-malignant microenvironment (TME) cells, independent malignant lysis. Relative other agonists, virotherapy provokes selective, TBK1-IRF3 driven inflammation associated with sustained type-I/III interferon...
Viruses naturally engage innate immunity, induce antigen presentation, and mediate CD8 T cell priming against foreign antigens. Polioviruses can provide a context optimal for generating antigen-specific cells, as they have natural tropism dendritic preeminent inducers of immunity; elicit Th1-promoting inflammation; lack interference with or adaptive immunity. However, notorious genetic instability underlying neuropathogenicity has hampered poliovirus-based vector applications. Here we...
Parkinson's disease (PD) is characterized by a progressive loss of dopaminergic neurons and consequent dopamine (DA) deficit, current treatment still remains challenge. Although neural stem cells (NSCs) have been evaluated as appealing graft sources, mechanisms underlying the beneficial phenomena are not well understood. Here, we investigate whether human NSCs (hNSCs) transplantation could provide neuroprotection against DA depletion recruiting endogenous to establish favorable niche. Adult...
Abstract Background Malignant gliomas commandeer dense inflammatory infiltrates with glioma-associated macrophages and microglia (GAMM) promoting immune suppression, evasion, tumor progression. Like all cells in the mononuclear phagocytic system, GAMM constitutively express poliovirus receptor, CD155. Besides myeloid cells, CD155 is widely upregulated neoplastic compartment of malignant gliomas. Intratumor treatment highly attenuated rhino:poliovirus chimera, PVSRIPO, yielded long-term...
Abstract Background Medulloblastoma is the most common malignant pediatric brain tumor, and leptomeningeal dissemination (LMD) of medulloblastoma both portends a poorer prognosis at diagnosis incurable recurrence. The biological mechanisms underlying LMD are unclear. Abelson (ABL) tyrosine kinase family members, ABL1 ABL2, have been implicated in cancer cell migration, invasion, adhesion, metastasis, chemotherapy resistance, upstream mediators oncogene c-MYC fibroblasts lung cells. However,...
Abstract Prevention and intervention methods are urgently needed to curb the global pandemic of coronavirus disease‐19 caused by severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2). Herein, a general pro‐antigen strategy for subunit vaccine development based on reversibly formulated receptor binding domain SARS‐CoV‐2 spike protein (S‐RBD) is reported. Since poor lymph node targeting uptake S‐RBD antigen‐presenting cells prevent effective immune responses, into reversible nanogel...
The application of disulfiram can be traced back to the 1920s, from when it was utilized facilitate alcohol abstinence by producing allergic reactions toward alcohol. In previous research, combination and copper ions has demonstrated significant anti-tumor activity. However, both lack ability specific targeting tumor tissues may lead a high risk side effects, especially for ion, which is kind toxic heavy metal. Herein, ferritin–albumin–Cu nanoparticle (FHC NP) introduced. synthesized first...
Background Antitumor mechanisms of CD4 + T cells remain crudely defined, and means to effectively harness T-cell help for cancer immunotherapy are lacking. Pre-existing memory hold potential be leveraged this purpose. Moreover, the role pre-existing immunity in virotherapy, particularly recombinant poliovirus where childhood polio vaccine specific is ubiquitous, remains unclear. Here we tested hypothesis that vaccine-specific mediate antitumor contribute efficacy virotherapy. Methods The...
Anastomotic leakage is a serious surgical complication in rectal cancer; however, effective evaluation methods for predicting anastomotic individual risk patients are not currently available. This study aimed to develop method evaluate the of during surgery. The 163 with cancer, who had undergone anterior resection and low-ligation procedures Doppler sonographic hemodynamic measurement from April 2011 January 2015 Peking University Cancer Hospital, were prospectively recruited. A predictive...
Background: Physicians play a unique role in scientific and clinical research, which is the cornerstone of evidence-based medical practice. In China, tertiary public hospitals link promotions bonuses with publications. However, weight placed on research clinician’s evaluation process its potential impact practice have come under controversy. Despite heated debate about physicians’ there little empirical evidence relationship between publications their outcomes. Method: This paper examines...
A 4-year-old girl presented with a 4-month history of progressive exotropia. There was no headache, impaired upgaze, nystagmus and vision changes. Complete neurological examination otherwise normal. MRI the brain revealed 1.5 cm cystic lesion in pineal region. The cyst had smooth margin lined by thin wall <1 mm that homogenously enhancing on contrast scan. Compared to cerebrospinal fluid, content isointense T1 hyperintense T2-weighted images (figure 1). …
Abstract Malignant gliomas commandeer an abundant inflammatory infiltrate with glioma-associated macrophages and microglia (GAMM) actively promoting tumor progression. Like all cells in the mononuclear phagocytic system, constitutively express poliovirus receptor, CD155. Besides myeloid cells, CD155 is widely upregulated ectopically neoplastic compartment of malignant (and solid cancers general). Intratumor treatment highly attenuated rhino:poliovirus chimera, PVSRIPO, yielded long-term...
Objective To determine whether there are significant differences in costs of treatment and readmission rates for hospital consultations undertaken by female versus male physicians China. Methods Using data from the Urban Employee Basic Medical Insurance program January 2018 through October 2019, we investigated spending patterns clinical outcomes patients at tertiary hospitals one largest cities China gender attending physician. Our sample included 79,085 hospitalizations treated 3993...
Abstract BACKGROUND T cell dysfunction is well documented in patients with gliomas, yet mechanisms explaining gliomas are lacking. Recent evidence links CXCR3 signaling and functional immune surveillance both preclinical models human data sets. METHODS Bulk single RNA-seq sets were used to compare ligand expression that of other solid tumor types. The role mediating the recruitment phenotype infiltrating lymphocytes (TILs) was tested using blockade genetic deletion murine models. capacity...
<h3>Background</h3> PVSRIPO, a recombinant poliovirus derived from the live-attenuated Sabin oral polio vaccine strain, is being tested in multi-institutional phase II clinical trials for recurrent glioblastoma (NCT04479241) and unresectable, PD-1 refractory melanoma (NCT04577807) combination with PD1 blockade. PVSRIPO capsid identical to strain >99% inactivated Polio (IPOL, Salk), against which public health mandated childhood vaccination near universal. In non-vaccinated mice, mediates...
Abstract BACKGROUND H3 K27M-mutant diffuse midline glioma (DMG) is invariably lethal. Viruses naturally engage innate immunity, induce antigen presentation, and mediate CD8 T cell priming against foreign antigens. Polioviruses, in particular, are uniquely tropic for dendritic cells (DC) potently activate DC, inducing Th1-dominant cytokine profiles, enhanced epitope presentation. Thus, poliovirus ideally suited vectored delivery of signature tumor neoantigens, e.g. the K27M feature DMG....