A5007014098- MicroRNA in disease regulation
- Renal and related cancers
- CAR-T cell therapy research
- Extracellular vesicles in disease
- Viral Infectious Diseases and Gene Expression in Insects
- Microbial Metabolic Engineering and Bioproduction
- Bioinformatics and Genomic Networks
- Epigenetics and DNA Methylation
- Virus-based gene therapy research
- CRISPR and Genetic Engineering
- Birth, Development, and Health
- Biosimilars and Bioanalytical Methods
- Computational Drug Discovery Methods
- Mast cells and histamine
- Psoriasis: Treatment and Pathogenesis
- Circular RNAs in diseases
- Renal cell carcinoma treatment
- Dermatology and Skin Diseases
- Machine Learning in Bioinformatics
- Cell Adhesion Molecules Research
- Cancer-related molecular mechanisms research
- Integrated Circuits and Semiconductor Failure Analysis
Allogene Therapeutics (United States)
2022-2024
AbbVie (United States)
2019
Regulus Therapeutics (United States)
2014-2015
University of Cincinnati
2011
Cincinnati Children's Hospital Medical Center
2008-2010
MicroRNA-21 (miR-21) contributes to the pathogenesis of fibrogenic diseases in multiple organs, including kidneys, potentially by silencing metabolic pathways that are critical for cellular ATP generation, ROS production, and inflammatory signaling. Here, we developed highly specific oligonucleotides distribute kidney inhibit miR-21 function when administered subcutaneously evaluated therapeutic potential these anti-miR-21 chronic disease. In a murine model Alport nephropathy, did not...
A chromosome 14 inversion was found in a patient who developed bone marrow aplasia following treatment with allogeneic chimeric antigen receptor (CAR) Tcells containing gene edits made transcription activator-like effector nucleases (TALEN). TALEN editing sites were not involved at either breakpoint. Recombination signal sequences (RSSs) suggesting recombination-activating (RAG)-mediated activity. The represented dominant clone detected the context of decreasing absolute CAR Tcell and...
ABSTRACT Extracellular vesicles (EVs) have great potential as a source for clinically relevant biomarkers since they can be readily isolated from biofluids and carry microRNA (miRNA), mRNA, proteins that reflect disease status. However, the biological technical variability of EV content is unknown making comparisons between healthy subjects patients difficult to interpret. In this study, we sought establish laboratory bioinformatics analysis pipeline analyse small RNA within EVs patient...