A5101466058- Virus-based gene therapy research
- Animal Virus Infections Studies
- MicroRNA in disease regulation
- Renin-Angiotensin System Studies
- Mesenchymal stem cell research
- Phosphodiesterase function and regulation
- Biofuel production and bioconversion
- Microbial Metabolic Engineering and Bioproduction
- Cancer-related molecular mechanisms research
- Metabolism and Genetic Disorders
- Neurogenesis and neuroplasticity mechanisms
- Bacteriophages and microbial interactions
- Mitochondrial Function and Pathology
- Cholesterol and Lipid Metabolism
- Microbial infections and disease research
- Metabolomics and Mass Spectrometry Studies
- RNA Interference and Gene Delivery
- Cancer, Hypoxia, and Metabolism
- Folate and B Vitamins Research
- Medicinal Plant Pharmacodynamics Research
- Enzyme Catalysis and Immobilization
- Neuroinflammation and Neurodegeneration Mechanisms
- Systemic Lupus Erythematosus Research
- Bone Tissue Engineering Materials
- HIV Research and Treatment
Beijing University of Chemical Technology
2025
Xijing Hospital
2020-2025
Chinese PLA General Hospital
2020-2025
Dalian University of Technology
2021-2024
Peking University
2023-2024
National Clinical Research Center for Digestive Diseases
2023-2024
Dalian University
2021-2024
Air Force Medical University
2014-2024
Mudanjiang Medical University
2023
Zhengzhou University
2013-2022
Abstract For bone defect repair under co-morbidity conditions, the use of biomaterials that can be non-invasively regulated is highly desirable to avoid further complications and promote osteogenesis. However, it remains a formidable challenge in clinical applications achieve efficient osteogenesis with stimuli-responsive materials. Here, we develop polarized CoFe 2 O 4 @BaTiO 3 /poly(vinylidene fluoridetrifluoroethylene) [P(VDF-TrFE)] core-shell particle-incorporated composite membranes...
Abstract Bone tissue renewal can be enhanced through co-transplantation of bone mesenchymal stem cells (BMSCs) and vascular endothelial (ECs). However, there are apparent limitations in cell-based therapy which hinder its clinic translation. Hence, we investigated the potential alternative cell substitutes for facilitating regeneration. In this study, successfully prepared membrane vesicles (CMVs) from BMSCs ECs. The results showed that BMSC-derived (BMSC-CMVs) possessed receptors involved...
Abstract The mtDNA copy number can affect the function of mitochondria and play an important role in development diseases. However, there are few studies on mechanism variation its effects IS. specific is still unclear. In this study, 101 IS patients normal controls were detected by qRT‐PCR, effect D‐loop was explored. Then, a TFAM gene KD‐OE PC12 cell model constructed to explore mitochondrial function. results showed that level group significantly lower than control ( p < 0.05)....
Mesenchymal stem cell (MSC) migration determines the healing capacity of bone and is crucial in promoting regeneration. Migration MSCs highly dependent on degradation extracellular matrix by proteolytic enzymes. However, underlying mechanisms how enzymolysis paves way for to migrate from their niche defect area still not fully understood. Here, this study shows that high-temperature requirement A3 (HtrA3) overcomes physical barrier provides anchor points through collagen IV degradation,...
CGG/GGC repeat expansion in FMR1 and NOTCH2NLC is reportedly associated with movement disorders; therefore, we hypothesized that the CGG LRP12, NUTM2B-AS1, GIPC1, which was previously identified myopathy, might also be movement-disorder phenotypes. Here, investigated whether GIPC1 presents a cohort of patients disorders.We screened for 1,346 1,451 matched healthy controls.No or controls harbored expanded repeats LRP12 whereas 16 >40 11 these harboring >60 repeats. One control individual an...
Background: Homocysteine (Hcy) plays an important role in vascular function and Hcy level contributes to pathogenesis of ischemic stroke (IS). MTHFR gene polymorphism may have effects on IS risks by influencing the metabolic pathway. In present study, a case–control study was designed evaluate relationship among C677Tpolymorphism, plasma level, susceptibility Chinese population. Methods: A total 300 patients with 261 matched control subjects were recruited. Plasma concentration determined...
A chromosome 14 inversion was found in a patient who developed bone marrow aplasia following treatment with allogeneic chimeric antigen receptor (CAR) Tcells containing gene edits made transcription activator-like effector nucleases (TALEN). TALEN editing sites were not involved at either breakpoint. Recombination signal sequences (RSSs) suggesting recombination-activating (RAG)-mediated activity. The represented dominant clone detected the context of decreasing absolute CAR Tcell and...
The relationship between Metabolic Syndrome (MetS) and ovarian dysfunction has been widely reported in observational studies, yet it remains not fully understood. This study employs genetic prediction methods utilizes summary data from genome-wide association studies (GWAS) to investigate this causal link. We employed a bidirectional two-sample Mendelian Randomization (MR) analysis utilizing MetS GWAS. Inverse variance weighted (IVW) was as the primary MR method, supplemented by Weighted...
Bioethanol is a significant product in the two-carbon strategy, but CO₂ generated during ethanol fermentation incurs substantial carbon losses. To tackle this issue, we explored prospective dual-enzyme approach,...
<title>Abstract</title> Phospholipase D (PLD) is a valuable enzyme in industrial processes for converting phosphatidylcholine (PC) to phosphatidylserine (PS). In this study, strain of <italic>Bacillus cereus</italic> was isolated from soil and identified through 16S rRNA sequencing. To enhance PLD activity, various mutagenesis strategies—including chemical treatment, irradiation, their combinations—were employed, resulting four high-activity positive mutants (C-7, I-12, CI 7–12, IC 13–14)....
Premature white matter injury (PWMI) represents the principal form of brain in preterm infants, and effective therapies remain elusive. Transplantation oligodendrocyte precursor cells (OPCs) emerges as a potential treatment for PWMI, yet injury-induced inflammatory response may impact these cells' functionality. To date, no studies have explored influence factors on functionality human (h) OPCs. The predominant cytokines identified PWMI lesions are tumor necrosis factor (TNF)-α interleukin...
Abstract Background Age-related bone loss plays a vital role in the development of osteoporosis and osteoporotic fracture. Bone marrow stromal cell (BMSC) senescence is highly associated with limits application BMSCs regenerative medicine. Hypoxia an essential component for maintaining normal physiology BMSCs. We have reported that activation hypoxia-induced factor by deletion von Hippel-Lindau gene osteochondral progenitor cells protected mice from aging-induced loss. However, whether...
Neurocysticercosis (NCC) is the most common parasitic disease of human central nervous system (CNS). However, a diagnosis NCC may be hard to make if specific clinical and routine neuroimaging manifestations are lacking, which hinders physicians from considering further immunodiagnostic tests. Seven patients presented with fever, headache, nausea, cognitive decline, confusion, or progressive leg weakness. There were no pathogens found in cerebrospinal fluid (CSF); clinically suspected...
Background: Previous studies have shown that the phosphodiesterase 4D (PDE4D) gene is a susceptibility for ischemic stroke (IS) primarily in elder populations. However, few reported role of PDE4D polymorphisms young cohort. Aims: To investigate association between and young-onset IS Chinese population. Materials Methods: A total 186 patients (18-45 years) with 232 matched control subjects were recruited. Two SNPs (rs918592 rs2910829) genotyped by polymerase chain reaction-restriction...
No coding sequence variants of the gene encoding 5-lipoxygenase-activating protein (ALOX5AP) leading to amino acid substitutions have been identified. Therefore, in ALOX5AP promoter region received attention recently. The purpose this study was explore whether polymorphism rs17222919 is involved etiology ischemic stroke (IS) Chinese Han population. We investigated by TaqMan genotyping two independent samples: first comprised 910 IS patients and 925 healthy inhabitants from northern Henan...
Interferon regulatory factor 8 (IRF8) has been shown to have diverse roles in the regulation of immune system. Two recent studies had revealed association between single-nucleotide polymorphisms (SNPs; rs11644034 and rs2280381) IRF8 systemic lupus erythematosus (SLE) a multiethnic population. The purpose this study was evaluate whether could be replicated Chinese Han Genotypes were determined by multiplex polymerase chain reaction-ligase detection reaction (PCR-LDR) 358 patients 357...
Epigenetic modulations lead to changes in gene expression, including DNA methylation, histone modifications, and noncoding RNAs. In recent years, epigenetic modifications have been related the pathogenesis of different types cancer, cardiovascular disease, other diseases. Emerging evidence indicates that methylation could be associated with ischemic stroke (IS) plays a role pathological progression, but underlying mechanism has not yet fully understood. this study, we used human 850K...
Objective: This study investigates the application of metagenomic next-generation sequencing (mNGS) in diagnosis neurobrucellosis (NB). Methods: We retrospectively analyzed patients diagnosed with NB who underwent cerebrospinal fluid (CSF) mNGS testing Xijing Hospital from 2015 to 2021. Results: Among 20 individuals included study, serum rose bengal test was positive 11 out 16 cases, agglutination 13 CSF culture 6 and tests were 18 cases. Conclusion: demonstrates superior sensitivity;...