A5022073372- Analytical chemistry methods development
- Analytical Chemistry and Chromatography
- Radiation Effects and Dosimetry
- Protein purification and stability
- Food Industry and Aquatic Biology
- Agriculture and Biological Studies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Cytokine Signaling Pathways and Interactions
- Plasma Applications and Diagnostics
- Educational Methods and Teacher Development
- Blood Pressure and Hypertension Studies
- Microfluidic and Capillary Electrophoresis Applications
- Yersinia bacterium, plague, ectoparasites research
- interferon and immune responses
- Microbial Inactivation Methods
- Mass Spectrometry Techniques and Applications
- Immune Response and Inflammation
- Food Quality and Safety Studies
- Cardiovascular Health and Disease Prevention
- Education and Professional Development
- Psychology of Development and Education
- Meat and Animal Product Quality
- Bacillus and Francisella bacterial research
- Chemical Reactions and Isotopes
- Tracheal and airway disorders
All-Russian Scientific Research Institute of Radiology and AgroEcology
2021-2024
Kurchatov Institute
2023-2024
Research Institute of Radiology
2020-2023
Agroécologie
2020-2023
Privolzhsky Research Medical University
2019-2021
City Hospital No. 40
2020
Institute of Macromolecular Compounds
2003-2019
St Petersburg University
2019
All-Russian Scientific Research Institute of Experimental Veterinary Sciences. Ya.R. Kovalenko
2017-2018
Stavropol State Medical University
2016
RNase L and RNA-dependent protein kinase (PKR) are effectors of the interferon antiviral response that share homology in their pseudokinase domains, respectively. Sunitinib is an orally available, ATP-competitive inhibitor VEGF PDGF receptors used clinically to suppress angiogenesis tumor growth. also impacts IRE1, endoplasmic reticulum involved unfolded closely related L. Here, we report sunitinib a potent both PKR with IC(50) values 1.4 0.3 μM, In addition, flavonol activators IRE1...
The use of lytic viruses to preferentially infect and eliminate cancer cells while sparing normal is a promising experimental therapeutic approach for treating cancer. However, the efficacy oncolytic virotherapy often limited by two innate immunity pathways, protein kinase PKR 2′-5′-oligoadenylate (OAS)/RNase L systems, which are widely present in many but not all tumor cell types. Previously, we reported that anticancer drug, sunitinib, an inhibitor VEGF-R PDGF-R, has off-target effects...
The present study reports on the frequency and spectrum of genetic variants causative monogenic diabetes in Russian children with non‑type 1 mellitus. included 60 unrelated mellitus diagnosed before age 18 years. Genetic were screened using whole‑exome sequencing (WES) a panel 35 genes maturity onset young (MODY) transient or permanent neonatal diabetes. Verification WES results was performed PCR‑direct sequencing. A total 38 identified 33 out patients (55%). majority (27/33, 81.8%) had...
The endoribonuclease RNase-L is a type-I interferon (IFN)-regulated component of the innate immune response that functions in antiviral, antibacterial, and antiproliferative activities. produces RNA agonists RIG-I-like receptors, sensors cytosolic pathogen-associated RNAs induce cytokines including IFN-β. IFN-β receptors signaling mediate protective responses against experimental colitis colitis-associated cancer contribute to gastrointestinal homeostasis. Therefore, we investigated role for...
The aim of the study is to assess gender-related specifics COVID-19 course in patients under 55 years age.Materials and Methods.This pilot single-center continuous retrospective non-randomized was carried out repurposed infectious diseases hospital Privolzhsky Research Medical University (Nizhny Novgorod, Russia).The inclusion criterion age (up years) confirmed coronavirus infection.In groups based on gender differences (25 men, average 44.0±7.8 32 women, 41.9±9.1 years), we monitored...
The polymers based on ethylene glycol dimethacrylate (EGDMA) and dimethylaminoethyl methacrylate (DMAEMA) molecularly imprinted with uric acid (UA), UA-MIPs, were successfully synthesized.The binding activity of UA-MIPs towards UA was studied in depth using batch methods.The optimized sorbent UA-MIP-7-16 synthesized; this is an EGDMAcrosslinked system containing 16 mol% as the template.The character between xanthine a reference substance, since its chemical structure similar to that UA.The...
АННОТАЦИЯВ структуре эпизоотической ситуации на территории РФ доминирующее положение занимают болезни продуктивных животных, наносящие значительный экономический ущерб товарному производству, либо социально значимые заболевания, в основном антропозоонозы, которые, зачастую, угрожают человеческой жизни.Ликвидации этих заболеваний государство уделяет большое внимание и выделяет профилактику борьбу с ними необходимые ресурсы.В статье приведены данные мониторинга по распространению вирусного...
The article presents a molecular genetic study of genomes field isolates rabies virus isolated in the Vladimir, Moscow, Tver, Nizhny Novgorod and Ryazan regions, with aim carrying out phylogenetic analysis. We studied 20 samples purified PCR products containing nucleoprotein. were provided by Vladimir veterinary service. Sequencing analysis gene showed that 12 fragments under close to Central group virus; namely - 5 from region, 2 Moscow 3 Tver region. Eight regions attributed Eurasian group.
The frontal dynamics of the sorption and desorption antibacterial antibiotic erythromycin on molecularly imprinted monoliths base 2-hydroxyethyl methacrylate ethylene glycol dimethacrylate non-imprinted analog was investigated. In contrast to large molecules, determined not only by convective mass transfer, but also gel diffusion into weakly cross-linked regions polymer sorbents molecular imprinting matrix resulted in an increase diffusion. At from polymeric monoliths, individual front...
The aim of this study was to characterize chronic respiratory infection in cystic fibrosis (CF) patients Russia according the National Russian CF Register. Methods. Register included 2,131 from 74 regions (2,092 alive and 39 died patients) 2014 (the median age, 10.2 (15.2) years; 29.2% were adults ≥ 18 лет). Microbiological findings (chronic caused by Staphylococcus aureus, Pseudomonas aeruginosa, Stenotrophomonas maltophilia, Burkholderia cepacia соmplex, non-tuberculous mycobacteria (NTM),...
Abstract Introduction/Purpose An acute drop in highly dialyzable antihypertensive drug levels is considered to be one of the pathophysiological mechanisms blood pressure rise during hemodialysis (HD). The study aimed assess prevalence intradialytic hypertension (ID-HTN) and identify most significant risk factors its development. Methods We performed a retrospective case-control single-center HD patients from January 1st, 2014 December 30th, 2016. Baseline evaluation included recording...