A5101402864- Reproductive Biology and Fertility
- Ovarian function and disorders
- Assisted Reproductive Technology and Twin Pregnancy
- Occupational exposure and asthma
- Reproductive Health and Technologies
- Occupational and environmental lung diseases
- Heart Failure Treatment and Management
- Cardiovascular and exercise physiology
- Sperm and Testicular Function
- Injury Epidemiology and Prevention
- Occupational Health and Safety Research
- Cardiovascular Function and Risk Factors
- Endometriosis Research and Treatment
- Orthopaedic implants and arthroplasty
- Advanced materials and composites
- Hepatitis B Virus Studies
- Heart Rate Variability and Autonomic Control
- Indoor Air Quality and Microbial Exposure
- Medical Imaging and Pathology Studies
- Chemical Safety and Risk Management
- Powder Metallurgy Techniques and Materials
- Global Health and Epidemiology
- Carbon Dioxide Capture Technologies
- Genetic factors in colorectal cancer
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Clatterbridge Cancer Centre NHS Foundation Trust
2024
National Institutes of Health
1998-2022
National Institute of Allergy and Infectious Diseases
2022
Lister Hospital
2012-2021
Eastern Health
2020
Imperial College London
2019
University of Nottingham
1997-2018
Park University
2018
University of Glasgow
2013
Royal Brompton Hospital
1995-2004
Flash carbonization is an attractive yet simple route for the preparation of biomass (sawdust) derived carbons that exhibit CO<sub>2</sub> uptake up to 5.0 mmol g<sup>−1</sup> (at 25 °C and 1 bar), exceptional working capacity pressure or vacuum swing adsorption processes under simulated flue gas conditions.
Ovarian reserve significantly influences IVF outcome. Low response to ovarian stimulation due reduction of is occasionally encountered in young women. The aim this study was evaluate the outcome treatment patients with reduced reserve.Between January 1993-2001, 762 consecutive satisfied definition (raised early follicular phase FSH or gonadotrophin cycles where three fewer oocytes were retrieved after routine stimulation) and included study. They classified into age groups: (< = 30 years),...
Neonatal encephalopathy is an important clinical problem * In this study the incidence of moderate or severe was found to be 3-75 per 1000 live term births, with a case fatality almost 8% Intrapartum hypoxia, determined tradi- tional criteria, not cause neonatal in most cases Signs intrapartum fetal distress may first signs pre-existing neurological abnor- mality, and events occurring antepartum period are abnormality newborn infants These results have implications for obste- tricians,...
We report two cases of occupational asthma caused by sensitisation to powdered fungicides fluazinam and chlorothalonil, from the same fungicide formulation plant. Both developed work related lower respiratory symptoms after a latent interval asymptomatic exposure. The diagnosis in each case was confirmed with serial peak flow record workplace followed specific inhalation tests. These are known cause dermatitis; this indicates that these compounds can induce immunological reactions airways as...
The successful outcome of intracytoplasmic sperm injection (ICSI) with round-headed spermatozoa (globozoospermia) is reported. A couple infertility secondary to globozoospermia received ICSI treatment. Fertilization, cleavage and pregnancy outcomes were recorded. This experienced 40, 10 42% fertilization rates after in their first, second third cycles respectively. Pregnancy did not occur the first or cycle but was successfully achieved cycle. It concluded that current procedures may...
To whom correspondence should be addressedThe timing of pronuclear formation and breakdown, DNA synthesis cleavage during the first cell cycle human embryogenesis are described.Pronuclei formed between 3 10 h post-insemination (hpi; median 8 hpi).S-phase commenced 14 hpi, was completed 18 hpi.M-phase observed 22 31 hpi (median duration h), to 2-cell stage took place 25 33 hpi.The same events determined in 1-cell embryos derived from re-inseminated oocytes that had failed fertilize...
Three employees from two different detergent companies were investigated for occupational asthma, using skin prick tests, serum specific IgE, and bronchial challenge. Two challenged with lipase one cellulase. All three cases had immunological evidence of sensitisation to the enzymes which they worked. Bronchial challenge in each provoked a reproducible dual asthmatic response, reproduced their work related symptoms. These are first reported asthma attributable cellulase industry. Four most...
We report a survey of the number persons handling laboratory animals in UK 1999-2000. This estimate has allowed us to calculate annual incidence rates allergic asthma and rhinitis attributable animals, insects, birds using numerators derived from cases reported national surveillance scheme (SWORD). The exposed employees almost halved since early 1980s. From these data, estimated rate occupational among working with small mammals is 1.56/1000 employees. Although are rare, (23.9/1000/year)...
Human embryos were disaggregated into component blastomeres 42-72 h after insemination. The scored for the number of nuclei present and known nuclear morphology returned to individual culture drops 16-20 h, which they cleavage morphology. In all, 48% mononucleated cleaved during this period, but only 76% these produced two daughter blastomeres; in remainder, one or more was abnormally nucleated. During overnight culture, 30% multinucleated anucleate cleaved, majority producing nucleated...
Summary Background Little is known about the prognosis of occupational asthma induced by high molecular weight proteins. Objective Our objective was to measure clinical, immunological and employment outcomes individuals with detergent enzymes. Methods We undertook a workforce‐based follow‐up study in 35 (78%) 45 ex‐employees from single factory asthma. In each case diagnosis supported evidence specific sensitization characteristic changes peak flow or positive response bronchial provocation...
3059 Background: Cancer of Unknown Primary (CUP) is a difficult to treat cancer entity for which the tumour origins remain elusive. There emerging evidence support precision medicine approach aid treatment decisions, however scarcity tissue molecular profiling remains challenge. CUPCOMP sought compare feasibility from both and blood in patients (pts) diagnosed with CUP. Methods: A non-randomised prospective clinical trial conducted across 7 UK sites between 06/2021-02/2023. Eligible pts had...
The Human Fertilisation and Embryology Authority requires all sperm donors to be screened for human immunodeficiency virus (HIV), hepatitis B C their semen quarantined six months. No guidelines exist screening prior in vitro fertilisation or intracytoplasmic injection. We prospectively analysed the prevalence of these viruses our patients. Screening detected one case HIV (0.13%), four (0.5%) 14 new cases (1.7%). antenatal population at this time was 1.4% 0.8%, respectively. Knowledge allows...
Sarcopenia is a decline in skeletal muscle mass and function. It associated with adverse outcomes increased mortality. also reported to be prevalent the hip fracture population. Our aims this study are compare hormonal profile women controls, assess relationship between biomarkers function these women.A cross sectional was performed enrolling above age 60 years old as group. For comparison healthy from community were recruited. Peripheral blood samples obtained for analysis of profiles....