A5063124042- Gut microbiota and health
- Alcohol Consumption and Health Effects
- Inflammasome and immune disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Cancer-related molecular mechanisms research
- Acute Ischemic Stroke Management
- Neural Networks and Applications
- Immune Response and Inflammation
- Reconstructive Surgery and Microvascular Techniques
- RNA modifications and cancer
- Physiological and biochemical adaptations
- Aquaculture Nutrition and Growth
- Gout, Hyperuricemia, Uric Acid
- Clostridium difficile and Clostridium perfringens research
- Flavonoids in Medical Research
- RNA Research and Splicing
- Phytoestrogen effects and research
- Antimicrobial Peptides and Activities
- Neurosurgical Procedures and Complications
- Neurological Disease Mechanisms and Treatments
- MicroRNA in disease regulation
- Quantum chaos and dynamical systems
- RNA and protein synthesis mechanisms
- Machine Learning and Algorithms
- Metabolomics and Mass Spectrometry Studies
State Key Laboratory of Food Science and Technology
2023-2025
Chinese Academy of Fishery Sciences
2025
Dalian Ocean University
2025
Nanchang University
2023-2025
Ludong University
2025
Shandong Special Equipment Inspection Institute
2025
Jiangxi University of Traditional Chinese Medicine
2020-2024
Shanghai Pulmonary Hospital
2023-2024
Tongji University
2023-2024
Wenzhou University
2024
Mycobacterium tuberculosis (Mtb) triggers distinct changes in macrophages, resulting the formation of lipid droplets that serve as a nutrient source. We discover Mtb promotes by inhibiting DNA repair responses, activation type-I IFN pathway and scavenger receptor-A1 (SR-A1)-mediated droplet formation. Bacterial urease C (UreC, Rv1850) inhibits host interacting with RuvB-like protein 2 (RUVBL2) impeding RUVBL1-RUVBL2-RAD51 complex. The suppression this increases abundance micronuclei trigger...
Adaptation to hypoxia is a major challenge for the survival of Mycobacterium tuberculosis (Mtb) in vivo. Interferon (IFN)-γ-producing CD8
Abstract Antimicrobial peptides (AMPs), ancient scavengers of bacteria, are very poorly induced in macrophages infected by Mycobacterium tuberculosis ( M. ), but the underlying mechanism remains unknown. Here, we report that L-alanine interacts with PRSS1 and unfreezes inhibitory effect on activation NF-κB pathway to induce expression AMPs, mycobacterial alanine dehydrogenase (Ald) Rv2780 hydrolyzes reduces level macrophages, thereby suppressing AMPs facilitate survival mycobacteria....
Abstract Internal N 6 -methyladenosine (m A) modifications are among the most abundant of messenger RNA, playing a critical role in diverse biological and pathological processes. However, functional regulatory mechanism m A immune response to Mycobacterium tuberculosis infection remains unknown. Here, we report that methyltransferase-like 14 (METTL14)-dependent methylation NAPDH oxidase 2 ( Nox2 ) mRNA was crucial for host defense against M. -secreted antigen EsxB (Rv3874) inhibited...
Panaxatriol saponins (PTS), an extract from the traditional Chinese herb Panax notoginseng, which has been used to treat ischemic stroke for many years in China. However, mechanism underlying effects of PTS remains unclear. This study aimed determine whether can protect against brain injury by promoting angiogenesis and explore possible it promotes angiogenesis.Middle cerebral artery occlusion (MCAO) was induced rats, neurological deficit scores infarct volumes were assessed. Micro-Positron...
// Yong Sun 1, * , Hongyu Cheng Guangjun Wang 1 Guojun Yu Dawei Zhang Yibing Wei Fan 2 Weixi Yang Department of Burn and Plastic Surgery, Huai’an First People’s Hospital, Nanjing Medical University, Huai’an, China Anesthesiology, These authors have contributed equally to this work Correspondence to: Fan, email: fanwei_2020@163.com Yang, SSZX_hayy@163.com Keywords: miR-183, MALAT1, ITGB1, melanoma, competitive endogenous RNA Received: September 01,...
PMA (propidium monoazide) is one of the few methods that are compatible with metagenomic sequencing to characterize live/intact microbiota. However, its efficiency in complex communities such as saliva and feces still controversial. An effective method for depleting host dead bacterial DNA human microbiome samples lacking. Here, we systematically evaluate osmotic lysis PMAxx treatment (lyPMAxx) characterizing viable four live/dead Gram+/Gram- microbial strains simple synthetic spiked-in...
Welding defects threaten structural integrity, demanding efficient and accurate detection methods. Traditional radiographic testing interpretation is subjective, necessitating automated solutions to improve accuracy efficiency. This study integrates wavelet transform convolutions (WTConv) into YOLOv11n, creating WT-YOLO, enhance defect in X-ray films. Wavelet transforms enable multi-resolution analysis, extracting both high-frequency low-frequency features critical for detecting various...