A5100461521- Pelvic and Acetabular Injuries
- Cardiac Ischemia and Reperfusion
- Hip and Femur Fractures
- Spinal Fractures and Fixation Techniques
- Anesthesia and Neurotoxicity Research
- Bone fractures and treatments
- Orthopedic Infections and Treatments
- Autophagy in Disease and Therapy
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Traditional Chinese Medicine Analysis
- Shoulder and Clavicle Injuries
- Hip disorders and treatments
- Knee injuries and reconstruction techniques
- Anesthesia and Sedative Agents
- Mitochondrial Function and Pathology
- Total Knee Arthroplasty Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Biochemical effects in animals
- Hydrogen's biological and therapeutic effects
- Anesthesia and Pain Management
- Cancer, Lipids, and Metabolism
- Muscle and Compartmental Disorders
- Spine and Intervertebral Disc Pathology
- Cellular transport and secretion
Harbin Medical University
2022-2025
Ocean University of China
2024-2025
Nanjing Medical University
2025
General Hospital of Shenyang Military Region
2015-2024
Shenzhen University
2023-2024
Tsinghua University
2024
Chinese PLA General Hospital
2019-2023
Air Force Medical University
2023
Fujian Medical University
2023
Panzhihua University
2023
The existence of cancer stem cells (CSCs) in non-small cell lung (NSCLC) has profound implications for therapy. In this study, a disulfiram/copper (DSF/Cu) complex was evaluated vitro and vivo its efficacy to inhibit CSCs, which drive recurrence NSCLC. First, we investigated whether DSF/Cu could ALDH-positive NSCLC tumors derived from sorted CSCs vivo. (0.5/1 μmol/l) significantly inhibited the expression transcription factors (Sox2, Oct-4 Nanog) reduced capacities self-renewal,...
The endoplasmic reticulum (ER)-Golgi sterol transfer activity of oxysterol-binding protein (OSBP) regulates sphingomyelin (SM) synthesis, as well post-Golgi cholesterol efflux pathways. phosphorylation and ER-Golgi localization OSBP are correlated, suggesting this modification the directionality and/or specificity activity. In paper, we report that on two serine-rich motifs, S381-S391 (site 1) S192, S195, S200 2), specifically controls at ER. A phosphomimetic SM/cholesterol-sensitive site 1...
Abstract Targeting CD96 that originates in immune cells has shown potential for cancer therapy. However, the role of intrinsic solid tumor remains unknown. Here, it is found frequently expressed from clinical breast samples and correlated with poor long‐term prognosis these patients. The + cell subpopulations exhibit features both stem chemoresistance. In vivo inhibition cell‐intrinsic enhances chemotherapeutic response a patient‐derived xenograft model. Mechanistically, mitochondrial fatty...
Nicotinamide adenine dinucleotide (NAD(+) ) not only transfers electrons in mitochondrial respiration, but also acts as an indispensable cosubstrate for Sirt1, the class III histone/nonhistone deacetylase. However, NAD(+) is depleted myocardial ischemia/reperfusion (IR) injury. The objective of this study was to investigate role exogenous supplementation hypoxia/reoxygenation (HR)-stressed H9c2 cardiac myoblasts. Firstly, effects distinct treating time points and doses on viability...
We designed a novel anterior cervical spine surgery preoperative treatment comprising mechanical trachea/esophagus traction and compared the postoperative outcome regarding dysphagia with nontreated patients.We investigated whether newly developed tracheal/esophageal exercise (TTE) has an effect on after surgery.Dysphagia is complication that occurs surgery, known treatments are perioperative application of methylprednisolone, monitoring endotracheal tube cuff pressure, use low-profile...
Tanshinol has desirable antianginal and pharmacokinetic properties is a key compound of <i>Salvia miltiorrhiza</i> roots (Danshen). It extensively cleared by renal excretion. This study was designed to elucidate the mechanism underlying tubular secretion tanshinol compare different ways manipulate systemic exposure compound. Cellular uptake mediated human organic anion transporter 1 (OAT1) (<i>K</i><sub>m</sub>, 121 <i>μ</i>M), OAT2 (859 OAT3 (1888 OAT4 (1880 <i>μ</i>M) rat Oat1 (117...
Oxysterol binding protein (OSBP) and OSBP-related proteins (ORPS) have a conserved lipid-binding fold that accommodates cholesterol, oxysterols and/or phospholipids. The diversity of OSBP/ORPs their potential ligands has complicated the analysis transfer signalling properties this mammalian gene family. In study we explored use fluorescent sterol cholestatrienol (CTL) to measure by ORP9 competition other putative ligands. Relative CTL dehydroergosterol (DHE) were poor for OSBP. contrast,...
In the recent decade, there has been substantial progress in technologies and philosophies associated with diagnosing treating anterior cruciate ligament (ACL) injuries China. The therapeutic efficacy of ACL reconstruction re-establishing stability knee joint garnered widespread acknowledgment. However, path toward standardizing diagnostic treatment protocols remains to be further developed refined.
ABSTRACT Aims We aimed to assess changes in the burden of diabetes Western Pacific region (WPR) between 1990 and 2019, project future trends for 2020–2044, identify factors influencing these trends. Materials Methods Data from Global Burden Disease Study 2019 were used calculate age‐standardised incidence rate (ASIR), death (ASDR) disability‐adjusted life years (DALYs) region. The Nordpred model was predict diabetes‐related ASIR ASDR over next 25 years, an age‐period‐cohort (APC) analysed...
<title>Abstract</title> Background In 2020, the World Federation Dental highlighted importance of oral health in "Vision 2030," noting widespread impact disorders, which affected 3.5 billion people 2019. Despite their prevalence, these disorders are often overlooked healthcare due to non-life-threatening nature. This study evaluates global, regional, and national burden from 1990 2021, providing insights for future policies addressing inequalities. Methods We analyzed data GBD 2021 database,...
<title>Abstract</title> Flexible surgical instruments with multiple degrees of freedom or continuum demonstrate substantial advantages in Natural Orifice Transluminal Endoscopic Surgery (NOTES), particularly when navigating the complex anatomical pathways human gastrointestinal tract. However, conventional endoscopic fixed diameters and stiffness profiles risk exerting excessive mechanical stress on esophageal tissues, clinical studies documenting mucosal tears hemorrhagic complications up...
Objectives In the context of demographic structure and disease spectrum changes: to study role medical insurance system in providing protection risk resilience for middle-aged elderly vulnerable groups who are prone impoverishment by expenses (IME), identify points propose recommendations improving system. Setting The research used data from 2018 China Health Retirement Longitudinal Study. Participants 9184 households were included ultimately. Primary secondary outcome measures We use WHO’s...
To determine the anti-edema effects of melatonin on spinal cord injury (SCI) in rats.A total 150 adult male Sprague-Dawley rats were randomly allocated to following three groups (n=50): a sham group which underwent laminectomy without dural compression; an SCI group, followed by and received saline i.p. immediately after then daily for 2 days; MT 100 mg/kg dose days. The cords removed at 12, 24, 48 72 h surgery every group. Spinal edema was evaluated determining water content. Expressions...
Retinoid X receptor (RXR) and Histone deacetylase (HDAC) are considered important targets for cancer therapy due to their crucial roles in genetic or epigenetic regulations of development progression. Here, we evaluated the potential dual targeting RXR HDAC using DW22 as a novel therapeutic approach treatment. We found that co-expression RXR-α HDAC1 was frequently appeared lung breast tissues cell lines. activated by RXRα overexpressed A549 MDA-MB-435 Meanwhile, inhibited activity decreasing...
Abstract Ferroptosis is a type of cell regulated necrosis triggered by intracellular phospholipid peroxidation, which more immunogenic than apoptosis. Therefore, genes controlling ferroptosis may be promising candidate biomarkers for tumor therapy. In this study, we investigate the function associated with in breast cancer (BC) and systematically evaluate relationship between ferroptosis-related gene expression prognosis BC patients from Cancer Genome Atlas database. By using consensus...
In this paper, we concluded that transient acidosis reperfusion conferred cardioprotection against myocardial ischemia injury in isolated rat hearts through activating PI3K-Akt-eNOS pathway.