A5101369389- Extracellular vesicles in disease
- Recommender Systems and Techniques
- Advanced Thermoelectric Materials and Devices
- Advanced Control Systems Optimization
- Thermal Radiation and Cooling Technologies
- RNA Interference and Gene Delivery
- Stability and Control of Uncertain Systems
- Ubiquitin and proteasome pathways
- MicroRNA in disease regulation
- Privacy-Preserving Technologies in Data
- Anomaly Detection Techniques and Applications
- Autophagy in Disease and Therapy
- Network Security and Intrusion Detection
- Power Systems and Technologies
- Cellular transport and secretion
- Adversarial Robustness in Machine Learning
- Histone Deacetylase Inhibitors Research
- Advanced Graph Neural Networks
- Advanced Sensor and Energy Harvesting Materials
- Vehicle License Plate Recognition
- Tannin, Tannase and Anticancer Activities
- Case Reports on Hematomas
- Dendrimers and Hyperbranched Polymers
- Generative Adversarial Networks and Image Synthesis
- Phytochemical Studies and Bioactivities
Sun Yat-sen University
2024-2025
Sun Yat-sen University Cancer Center
2024-2025
Soochow University
2023-2025
Guangzhou University of Chinese Medicine
2022-2024
Chengdu University of Traditional Chinese Medicine
2024
Xiamen Municipal Bureau of Science and Technology
2024
Donghua University
2022-2024
Wenzhou Medical University
2023
Shanghai University of Electric Power
2023
Fuzhou University
2023
Abstract The development of high‐performance thermoelectric devices (TEDs) with personal thermoregulation is crucial for the advancement next‐generation wearable technologies. Most efforts focus on optimizing mechanical flexibility in fully encapsulated devices, but parasitic heat loss induced by layer‐packed polymer matrices high thermal impedance typically leads to degradation sensing and bidirectional conversion capabilities. Here, a bioinspired architectural strategy proposed this...
Introduction The prevalence of chronic kidney disease (CKD) is gradually increasing in the elderly population. At same time, frailty has become one research hotspots field geriatrics. Bibliometric analyses help to understand direction a field. Therefore, this study aimed analyze status and emerging trends CKD patients.
Abstract Bladder cancer (BC) is one of the most common tumors characterized by a high rate relapse and lack targeted therapy. Here, YEATS domain‐containing protein 4 (YEATS4) an essential gene for BC cell viability using CRISPR‐Cas9 library screening reported, that HUWE1 E3 ligase responsible YEATS4 ubiquitination proteasomal degradation Protein Stability Regulators Screening Assay. KAT8‐mediated acetylation impaired its interaction with consequently prevented degradation. The levels KAT8...
Extracellular vesicles (EVs) are nanoparticles secreted by cells with a closed phospholipid bilayer structure, which can participate in various physiological and pathological processes have significant clinical value disease diagnosis, targeted therapy prognosis assessment. EV isolation methods currently include differential ultracentrifugation, ultrafiltration, size exclusion chromatography, immunoaffinity, polymer co-precipitation microfluidics. In addition, material-based biochemical or...
Extracellular vesicles (EVs) and their cargoes are increasingly being recognized as noninvasive diagnostic markers, necessitating the isolation of EVs from complex biological samples. Herein, a distearoyl phospholipid ethanolamine-functionalized single-crystal ordered macroporous three-dimensional zeolitic imidazolate framework (SOM-ZIF-8-DSPE) was developed, which combines surface charge interaction ZIF-8 with synergistic effect DSPE insertion into membrane to improve isolating selectivity...
Abstract Cervical cancer metastasis is characterized by the systemic spread of tumor cells. However, underlying mechanism remains incompletely understood. Herein, we demonstrate that RAB33A promoted enhancing RhoC accumulation and higher expression predicted poorer prognosis in patients with cervical cancer. Mechanistically, typically degraded via canonical autophagy due to binding two LIR motifs (LC3 interaction region) LC3; however, induced non-canonical autophagy, resulting stabilization,...
Abstract Aberrant transcriptional and epigenetic landscape plays crucial roles in the progression of bladder cancer (BC). However, effective therapeutic targets derived from these processes remain undeveloped. This study pinpoints SET‐domain‐containing protein 8 (SETD8) as a pivotal gene that promotes tumor growth through screening with CRISPR‐Cas9 library targeting factors. BC patient samples display elevated SETD8 expression, higher expression correlates poorer prognosis. Further, MYC is...
The hydrogel-based printing strategy was proposed to fabricate the high-performance flexible thermoelectric generators with high-power density, where stable water-locking network can limit fluidity of pastes.
The effective teaching design of mathematics should be designed carefully by teachers according to the situation students' learning and analysis materials. Its run through origin development knowledge generation, reasonably ensure continuity integrity teaching. Based on theory "6-Question Cognitive Theory", This research using method with steps make comparisons between this paper attempts a comparison "equal ratio sequence" sequence". Results in study show that Theory" embodies coherence,...
Long-term exposure to diethylhexyl phthalate (DEHP), an endocrine-disrupting chemical (EDCs) and plasticizer widely used in consumer products, has been reported be significantly positively correlated with increased risks of different human diseases, including various cancers, while the potential effect DEHP on colorectal cancer progression was little studied. In present study, we showed that could trigger metabolic reprogramming cells, promote cell growth decrease fluorouracil (5-FU)...
Propofol is widely used as a short-acting intravenous anaesthetic for the induction and maintenance of sedation. The application propofol expanding due to its advantages increasing demand painless diagnosis treatment. However, accumulating clinical experimental evidence has shown that can potentially be abused prone causing addiction. To further understand underlying mechanism addiction, our review places emphasis on explaining roles mesolimbic, noradrenergic, nitrergic systems in We have...
Abstract Microvesicles (MVs) containing proteins, nucleic acid or organelles are shed from the plasma membrane. Although mechanisms of MV budding well elucidated, connection between endosomal trafficking and formation remains poorly understood. In this report, RAB22A is revealed to be crucial for EGFR‐containing MVs by RAB GTPase family screening. recruits TBC1D2B, a GTPase‐activating protein (GAP) RAB7A, inactivate thus preventing EGFR being transported late endosomes lysosomes. also...
Background: Adipose tissue-derived stem cells (ADSCs), a type of mesenchymal cell, have been used extensively in clinical trials for the treatment multiple conditions, including sepsis. However, increasing evidence indicates that ADSCs vanish from tissues within days administration. Consequently, it would be desirable to establish mechanisms underlying fate following transplantation. Methods: In this study, sepsis serum mouse models was mimic microenvironmental effects. Healthy donor-derived...
Abstract With the increasingly prominent environmental problems, more and attention has been paid to new energy power generation. A photovoltaic generation is currently a well-developed form of However, in process generation, only part wavelength light can be used generate power. The rest will converted heat, which increases temperature panels, resulting lower efficiency. In order improve efficiency photovoltaic-temperature difference (PV-TE) hybrid system formed by combining with...
Electrocardiogram (ECG) monitoring owns important clinical value in diagnosis, prevention and rehabilitation of cardiovascular disease (CVD). With the rapid development Internet Things (IoT), big data, cloud computing, artificial intelligence (AI) other advanced technologies, wearable ECG is playing an increasingly role. aging process population, it more urgent to upgrade diagnostic mode CVD. Using AI technology assist analysis long-term ECGs, thus improve ability early detection prediction...
Breast cancer is the disease with largest number of diagnoses at present, which seriously threatens health women all over world. HER2 positive breast one subtypes, accounting for 25% -30% cases. Despite good progress in chemotherapy, radiation therapy, endocrine therapy and other areas, recovery remains a huge challenge. The development tumor therapeutic vaccines promising strategy. In recent years, more based on different carrier platforms have gradually been discovered. These stimulate...