A5045219378- Hemophilia Treatment and Research
- Liver Disease Diagnosis and Treatment
- Platelet Disorders and Treatments
- Hormonal Regulation and Hypertension
- Bacterial Genetics and Biotechnology
- Microbial Metabolic Engineering and Bioproduction
- Clostridium difficile and Clostridium perfringens research
- Alcohol Consumption and Health Effects
- RNA and protein synthesis mechanisms
- Autophagy in Disease and Therapy
- RNA Interference and Gene Delivery
- Electrolyte and hormonal disorders
- Kidney Stones and Urolithiasis Treatments
- Mosquito-borne diseases and control
- Antimicrobial Resistance in Staphylococcus
- RNA regulation and disease
- Infant Nutrition and Health
- Cancer-related gene regulation
- Monoclonal and Polyclonal Antibodies Research
- Vibrio bacteria research studies
- MicroRNA in disease regulation
- Escherichia coli research studies
- Birth, Development, and Health
- Bacteriophages and microbial interactions
- Cellular transport and secretion
University Hospital Bonn
2021-2025
University of Bonn
2023-2025
University of Würzburg
2018-2022
Epigenetic modifications (e.g. DNA methylation) in NAFLD and their contribution to disease progression extrahepatic complications are poorly explored. Here, we use an integrated epigenome transcriptome analysis of mouse hepatocytes identify alterations glyoxylate metabolism, a pathway relevant kidney damage via oxalate release-a harmful waste product stone-promoting factor. Downregulation hypermethylation alanine-glyoxylate aminotransferase (Agxt), which detoxifies glyoxylate, preventing...
Abstract A central question concerning natural competence is why orthologs of genes are conserved in non-competent bacterial species, suggesting they have a role other than transformation. Here we show that induction the human pathogen Staphylococcus aureus occurs response to ROS and host defenses compromise respiration during infection. Bacteria cope with reduced by obtaining energy through fermentation instead. Since energetically less efficient respiration, supply must be assured...
The availability of bulk-omic data is steadily increasing, necessitating collaborative efforts between experimental and computational researchers. While software tools with graphical user interfaces (GUIs) enable rapid interactive assessment, they are limited to pre-implemented methods, often requiring transitions custom code for further adjustments. However, the most available lack GUI-independent reproducibility such as direct integration R, resulting in very support transition. We...
Article2 November 2018Open Access Source DataTransparent process Stress-induced host membrane remodeling protects from infection by non-motile bacterial pathogens Caroline Tawk orcid.org/0000-0003-1781-5591 Host RNA Metabolism Group, Institute for Molecular Infection Biology (IMIB), University of Würzburg, Germany Search more papers this author Giulia Nigro Microbial Pathogenesis Laboratory, Institut Pasteur, Paris, France Ines Rodrigues Lopes Functional Genomics and RNA-based Therapeutics,...
Modulation of the host cell cycle has emerged as a common theme among pathways regulated by bacterial pathogens, arguably to promote colonization. However, in most cases exact benefit ensuing from such interference infection process remains unclear. Previously, we have shown that Salmonella actively induces G2/M arrest cells, and is severely inhibited cells arrested G1. In this study, demonstrate vacuolar replication blocked G1, whereas cytosolic closely related pathogen Shigella not...
Abstract Motivation The availability of bulk-omic data is steadily increasing, necessitating collaborative efforts between experimental and computational researchers. While software tools with graphical user interfaces (GUIs) enable rapid interactive assessment, they are limited to pre-implemented methods, often requiring transitions custom code for further adjustments. However, most available lack GUI-independent reproducibility such as direct integration R, resulting in very support...