A5027168297- CRISPR and Genetic Engineering
- Probiotics and Fermented Foods
- Genomics and Phylogenetic Studies
- Supramolecular Self-Assembly in Materials
- RNA and protein synthesis mechanisms
- Innovation and Socioeconomic Development
- RNA regulation and disease
- Metal-Organic Frameworks: Synthesis and Applications
- Polydiacetylene-based materials and applications
- Bacterial Genetics and Biotechnology
- Antimicrobial Resistance in Staphylococcus
- Infant Nutrition and Health
- Zoonotic diseases and public health
- Law, AI, and Intellectual Property
- Microbial Metabolites in Food Biotechnology
- Microbial Natural Products and Biosynthesis
- Surfactants and Colloidal Systems
- Hydrogels: synthesis, properties, applications
- Lipid Membrane Structure and Behavior
- Marine Sponges and Natural Products
- Plant and Fungal Interactions Research
- Genetics, Aging, and Longevity in Model Organisms
- RNA modifications and cancer
- COVID-19 Pandemic Impacts
- Advanced biosensing and bioanalysis techniques
National Institute of Pharmaceutical Education and Research
2023-2025
Visva-Bharati University
2018-2024
Sebacic acid-based thixotropic supramolecular Ni( ii )/Zn( )-metallogels are utilized for inhibiting poisonous bacteria and offering light-responsive semiconducting diodes with non-ohmic conduction mechanism.
The importance of three synthesized metallogels suberic acid distinctly with nickel, zinc, and cadmium acetate salts has been uncovered. For the creation these soft materials, N,N'-dimethyl formamide was utilized as a source trapped solvent. display intriguing viscoelasticity, interpretation experimental parameters obtained from rheological results advocates gel behavior. Microstructural analysis combined energy-dispersive X-ray confirms occurrence individual gel-developing constituents...
Molecular self-assembly assisted self-healing supramolecular metallogels of azelaic acid with cobalt(II)-, nickel(II)-, and zinc(II)-based metal acetate salts were successfully fabricated. Individually, N,N′-dimethylformamide dimethyl sulfoxide immobilized within these distinctly synthesized soft-scaffolds to attain their semisolid viscoelastic nature. Rheological experiments such as amplitude sweep, frequency thixotropic measurements executed for ratify gel features. The different extents...
Limited information is available on the whole-genome sequences of Kurthia spp. Here, we report, for first time, draft genome sequence gibsonii designated as strain B83. The was isolated from spinach (Spinacia oleracea L.) leaf. sequenced Illumina NextSeq 500 platform.
Dahi is a traditional Indian fermented milk consumed regularly as part of the diet because its palatability and health benefits. Here, we report draft genome sequence unique strain Lactococcus lactis subsp. lactis, W8, lactic acid bacterium that produces nisin while fermenting to dahi.
The therapeutic application of CRISPR-Cas9 is limited due to its off-target activity. To have a better understanding this effect, we focused on mismatch-prone PAM distal end. activity SpCas9 depends directly the nature mismatches, which in turn results deviation active site structural instability RNA-DNA duplex strand. In order test hypothesis, designed an array mismatched target sites at end and performed vitro cell line-based experiments, showed strong correlation for Cas9 We found that...
In this study, 1,4-benzothiazine-based bisamide derivatives, a new class of antibacterial agents targeting bacterial peptide deformylase (PDF), were designed and synthesized to combat Staphylococcus aureus infection. Molecular modeling the molecules showed better docking scores compared natural product actinonin. Bioactivity assessment identified two derivatives with promising activity in vitro . The stability most active molecule, 8bE , was assessed using molecular dynamics (MD) simulation....
The recent 2019-nCoV outbreak, spreading infection around the globe is jeopardizing public health and global economy. virus was reported to have emerged from an animal market in Wuhan, China at end of 2019 presumed originated bats eventually transmitted humans. entry into human cells triggered by a series molecular events initiated with binding receptor-binding domain viral spike protein Ace2 cell surface receptor. Based on comparative sequence analysis well-known hotspots Ace2,...
Abstract CRISPR-Cas9 is the newest technology available for targeted genome editing. It very efficient and cheap compared to other editing techniques. However, its therapeutic application limited due off-target activity. To have a better understanding of this effect, we concentrated our efforts on mismatch-prone PAM distal end. Current prediction algorithms use RNA-DNA complementation derived energy as major factor in predicting effect. drives Cas9 conformational change, which turn...