A5056882169- CRISPR and Genetic Engineering
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- RNA and protein synthesis mechanisms
- Computational Drug Discovery Methods
- Immune Cell Function and Interaction
- Transgenic Plants and Applications
- Epigenetics and DNA Methylation
- Toxin Mechanisms and Immunotoxins
- Micro and Nano Robotics
- Adversarial Robustness in Machine Learning
- Radar Systems and Signal Processing
- RNA regulation and disease
- Fungal Biology and Applications
- Domain Adaptation and Few-Shot Learning
- Animal Nutrition and Physiology
- Nanoparticle-Based Drug Delivery
- Metal complexes synthesis and properties
- Acute Lymphoblastic Leukemia research
- Machine Learning and Data Classification
- Ferrocene Chemistry and Applications
- Herbal Medicine Research Studies
- Chemokine receptors and signaling
National Institute of Pharmaceutical Education and Research
2017-2025
University of Calcutta
2003-2025
Visva-Bharati University
2024
Hitachi (United Kingdom)
2023
University of Minnesota
2023
Hitachi Global Storage Technologies (United States)
2019-2022
K Lab (United States)
2022
University of Engineering & Management
2021
Institute of Engineering
2021
Hitachi (Japan)
2020
Three mononuclear organotin(IV) complexes supported by Schiff bases have been synthesized. The [(C 6 H 5 ) 2 Sn(L)] ( 1 ), [( t ‐Bu) and Sn(L')] 3 (L, L' = deprotonated bases) were obtained in good yield the reaction of L or L′ with corresponding diorganotin dichlorides respectively. All newly synthesized characterized means FT‐IR spectroscopy, elemental analysis multinuclear H, 13 C 119 Sn) NMR spectroscopy. In addition, single crystal X‐ray diffraction analyses employed to establish solid...
The current pandemic, caused by SARS-CoV-2 virus, is a severe challenge for human health and the world economy. There an urgent need development of drugs that can manage this as it has already infected 19 million people led to death around 711,277 worldwide. At time, in-silico studies are providing lots preliminary data about potential drugs, which be great help in further in-vitro in-vivo studies. Here, we have selected three polyphenolic compounds, mangiferin, glucogallin, phlorizin. These...
To swim through a viscous fluid, flagellated bacterium must overcome the fluid drag on its body by rotating flagellum or bundle of multiple flagella. Because increases with size bacteria, it is expected theoretically that swimming speed inversely correlates length. Nevertheless, despite extensive research, fundamental size-speed relation bacteria remains unclear different experiments reporting conflicting results. Here, critically reviewing existing evidence and synergizing our own large...
In response to rising concerns about the environmental impact of standard chemical synthesis methods, Erythrina variegata leaf extract facilitated green CuO NPs for potent anticancer, antibacterial, and photocatalytic applications.
DNA binding and cleavage properties of three novel copper(<sc>ii</sc>) complexes involving azo Schiff base ligands have been studied.
B cell acute lymphoblastic leukaemia (B-ALL) cells express high levels of CXCR4 chemokine receptors for homing and retention within the marrow microenvironment. Bone stromal (BMSC) secrete CXCL12, ligand CXCR4, protect B-ALL from cytotoxic drugs. Therefore, therapeutic use antagonists has been proposed to disrupt cross talk between protective stroma. Because can have activating agonistic function, we compared genetic pharmacological deletion in cells, using CRISPR-Cas9 gene editing that are...
Recently published clinical data from COVID-19 patients indicated that statin therapy is associated with a better outcome and significant reduction in the risk of mortality. In this study by computational analysis, we have aimed to predict possible mechanism group drugs which they can inhibit SARS-CoV-2 pathogenesis. Blind docking critical structural functional proteins like RNA-dependent RNA polymerase, M-protease 3-CL-Pro, Helicase, Spike ( wild type mutants different VOCs) were performed...
To identify an HIV epitope suitable for vaccine development.Diverse HIV-1 strains express few structurally constant regions on their surface vulnerable to neutralizing antibodies. The mostly conserved CD4-binding site (CD4BS) of gp120 is essential host cell binding and infection by the virus. Antibodies that recognize CD4BS are rare, one component CD4BS, 421-433 peptide region, expresses B-cell superantigenic character, a property predicted impair anti-CD4BS adaptive immune response.IgA...
Abstract Induction of apoptosis is the target choice for modern chemotherapeutic treatment cancer, where lack potent “target‐specific” drugs has led to extensive research on anticancer compounds from natural sources. In our study, we have used astrakurkurone, a triterpene isolated wild edible mushroom, Astraeus hygrometricus . We discussed structure and stability astrakurkurone employing single‐crystal X‐ray crystallography studied its potential apoptogenicity in hepatocellular carcinoma...
The anti-oxidant and anti-inflammatory effect of beta-glucogallin (BGG), a plant-derived natural product, was evaluated in both vitro vivo studies. For the study, ability BGG pre-treatment to quench LPS-induced effects compared LPS alone macrophages investigated. It found that showed significant decrease ROS, NO, superoxide, pro-inflammatory cytokines (TNF-alpha, IL-4, IL-17, IL-1β, IL-6) increased reduced glutathione coupled with restoration mitochondrial membrane potential. Gene profiling...