A5069048569- Air Quality and Health Impacts
- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Noise Effects and Management
- Biomarkers in Disease Mechanisms
- EEG and Brain-Computer Interfaces
- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Neuroscience and Neural Engineering
- COVID-19 impact on air quality
- Vascular Malformations Diagnosis and Treatment
- Neural dynamics and brain function
- Stroke Rehabilitation and Recovery
- Traumatic Brain Injury and Neurovascular Disturbances
- Anesthesia and Neurotoxicity Research
- Cardiac, Anesthesia and Surgical Outcomes
- Climate Change and Health Impacts
- Cardiovascular Health and Disease Prevention
- Aortic aneurysm repair treatments
- Dementia and Cognitive Impairment Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Anesthesia and Pain Management
- Advanced Neuroimaging Techniques and Applications
- Health, Environment, Cognitive Aging
University of Southern California
2018-2024
Neurological Surgery
2020-2024
Keck Hospital of USC
2022
University of California, San Francisco
2020
Epidemiological studies have established an association between air pollution particulate matter exposure (PM2.5) and neurocognitive decline. Experimental data suggest that microglia play essential role in PM-induced neuroinflammation oxidative stress. This study examined the effect of nano-sized (nPM) on complement C5 deposition microglial activation corpus callosum mice (C57BL/6J males). nPM was collected urban Los Angeles region impacted by traffic emissions. Mice were exposed to 10 weeks...
Air pollution particulate matter exposure and chronic cerebral hypoperfusion (CCH) contribute to white toxicity through shared mechanisms of neuroinflammation, oxidative stress, myelin breakdown. Prior studies showed that mice joint CCH caused supra-additive injury corpus callosum matter. This study examines the role TLR4 (toll-like receptor 4) signaling in mediating neurotoxicity damage observed exposures.
Background: Exposure to ambient air pollution particulate matter (PM) is associated with increased risk of dementia and accelerated cognitive loss. Vascular contributions impairment are well recognized. Chronic cerebral hypoperfusion (CCH) promotes neuroinflammation blood–brain barrier weakening, which may augment neurotoxic effects PM. Objectives: This study examined interactions nanoscale (nPM; fine aerodynamic diameter ≤200 nm) CCH secondary bilateral carotid artery stenosis (BCAS) in a...
Cerebrovascular pathologies are commonly associated with dementia. Because air pollution increases arterial disease in humans and rodent models, we hypothesized that would also contribute to brain vascular dysfunction. We examined the effects of exposing mice nanoparticulate matter (nPM; aerodynamic diameter ≤200 nm) from urban traffic interactions cerebral hypoperfusion. C57BL/6 were exposed filtered or nPM without bilateral carotid artery stenosis (BCAS) analyzed by multiparametric MRI...
Air pollution particulate matter (PM) is strongly associated with risks of accelerated cognitive decline, dementia and Alzheimer's disease. Ambient PM batches have variable neurotoxicity by collection site season, which limits replicability findings within between research groups for analysis mechanisms interventions. Diesel exhaust particles (DEP) offer a replicable model that we define in further detail.Define dose- time course neurotoxic responses mice to DEP from the National Institute...
Exposure to ambient air pollution has been associated with white matter damage and neurocognitive decline. However, the mechanisms of this injury are not well understood remain largely uncharacterized in experimental models. Prior studies have shown that exposure particulate (PM), a sub-fraction pollution, results neuroinflammation, specifically upregulation inflammatory microglia. This study examines axonal injury, characterizes microglial reactivity corpus callosum mice exposed 10 weeks...
Abstract Chronic cerebral hypoperfusion (CCH) may amplify the neurotoxicity of nanoscale particulate matter (nPM), resulting in white injury. This study characterized joint effects nPM (diameter ≤ 200 nm) and CCH secondary to bilateral carotid artery stenosis (BCAS) exposure on neuronal injury a murine model. was collected near highway re‐aerosolized for exposure. Ten‐week‐old C57BL/6 male mice were randomized into four groups: filtered air (FA), nPM, FA + BCAS, BCAS. Mice exposed or 10...
Background: Air pollution is widely associated with accelerated cognitive decline at later ages and risk of Alzheimer’s disease (AD). Correspondingly, rodent models demonstrate the neurotoxicity ambient air its components. Our studies nano-sized particulate matter (nPM) from urban Los Angeles collected since 2009 have shown pro-amyloidogenic pro-inflammatory responses. However, recent batches nPM diminished induction glutamate receptor GluA1 subunit, Iba1, TNFα, Aβ42 peptide, white damage....
Recently, efforts to produce artificial sensation through cortical stimulation of primary somatosensory cortex (S1) in humans have proven safe and reliable. Changes parameters like frequency amplitude been shown elicit different percepts, but without clearly defined psychometric profiles. This study investigates the functionally useful limits changes on percepts felt by three epilepsy patients with subdural electrocorticography (ECoG) grids. Subjects performing a hidden target task were...
Retrospective database study.
Background Stroke systems of care employ a hub-and-spoke model, with fewer centers performing mechanical thrombectomy (MT) compared stroke-receiving centers, where higher number offer high-level, centralized treatment to large patients. Objective To characterize rates and outcomes readmission index non-index hospitals for patients ischemic stroke who underwent MT. Methods This study leveraged population-based, nationally representative sample undergoing MT from the Nationwide Readmissions...
Air pollution is associated with risks of dementia and accelerated cognitive decline. Rodent air models have shown white matter vulnerability. This study uses diffusion tensor imaging (DTI) to quantify changes microstructure tractography in multiple myelinated regions after exposure diesel exhaust particulate (DEP). Adult C57BL/6 male mice were exposed re-aerosolized DEP (NIST SRM 2975) at a concentration 100 ug/m
OBJECTIVE Stimulation of the primary somatosensory cortex (S1) has been successful in evoking artificial somatosensation both humans and animals, but much is unknown about optimal stimulation parameters needed to generate robust percepts somatosensation. In this study, authors investigated frequency as an adjustable parameter for a closed-loop brain-computer interface (BCI) system. METHODS Three epilepsy patients with subdural mini-electrocorticography grids over hand area S1 were asked...
Metastases to the central nervous system are often multiple in number and typically favor gray-white matter junction. Collision tumors, defined as coexistence of two morphologically different such metastases a known pituitary adenoma (PA), exceedingly rare. Only few reported cases PA exist literature.The authors present case 64-year-old man with history stage IV metastatic melanoma who was found have hypermetabolic activity sellar region on surveillance positron emission tomography. On...
INTRODUCTION: Air pollution is recognized as a neurotoxin which damages white matter and increases the risk of cognitive decline. Our previous work in murine model found that air setting chronic cerebral hypoperfusion (CCH) leads to synergistic deleterious effect on matter. studies have shown increased microglial activation was associated with neurotoxicity. We hypothesize inhibition microglial-specific TLR4 pathway will decrease neurodegenerative effects normally result from combined CCH...
Microsurgical resection is the only curative intervention for symptomatic brainstem cavernous malformations (BSCMs), but management of these lesions in older adults (≥65 years) not well described. This study sought to address this gap by examining safety and efficacy BSCM a cohort adults.
To characterize the molecular underpinnings of recovery following acute diesel exhaust particle (DEP) exposure.
National and regional systems of stroke care are designed to provide patients with widespread access hospitals thrombolytic capabilities. However, such triaging may contribute fragmentation care. This study aims compare rates readmission outcomes between index non-index for following intravenous therapy (IVT). utilized a nationally representative sample IVT from the Nationwide Readmissions Database 2010 2014. Descriptive regression analyses were performed patient hospital level factors that...