A5108757681- Genomics, phytochemicals, and oxidative stress
- Air Quality and Health Impacts
- Sulfur Compounds in Biology
- Glutathione Transferases and Polymorphisms
- Noise Effects and Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Redox biology and oxidative stress
- Neurological Disease Mechanisms and Treatments
- Antioxidant Activity and Oxidative Stress
- Adipose Tissue and Metabolism
- Immune cells in cancer
- Energy and Environment Impacts
- Fibroblast Growth Factor Research
- IL-33, ST2, and ILC Pathways
- Iterative Learning Control Systems
- Amino Acid Enzymes and Metabolism
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Protein Tyrosine Phosphatases
- Retinoids in leukemia and cellular processes
- Nitrogen and Sulfur Effects on Brassica
- Climate Change and Health Impacts
- Vitamin C and Antioxidants Research
- Inflammatory mediators and NSAID effects
- Occupational and environmental lung diseases
- Folate and B Vitamins Research
University of Southern California
2015-2024
ShanghaiTech University
2024
Xiangnan University
2018-2024
University of California System
2023
Fifth Affiliated Hospital of Zhengzhou University
2017-2023
LAC+USC Medical Center
2022
East China Normal University
2022
Southern California University for Professional Studies
2011-2022
University of Electronic Science and Technology of China
2021
National Engineering Research Center of Electromagnetic Radiation Control Materials
2021
The ability to adapt acute oxidative stress (e.g. H(2)O(2), peroxynitrite, menadione, and paraquat) through transient alterations in gene expression is an important component of cellular defense mechanisms. We show that such adaptation includes Nrf2-dependent increases capacity degrade oxidized proteins are attributable increased the 20 S proteasome Pa28αβ (11 S) regulator. Increased levels Nrf2, translocation Nrf2 from cytoplasm nucleus, binding antioxidant response elements (AREs) or...
Evidence from animal studies suggests that stress-induced increases in Nrf2-regulated antioxidant gene expression, a critical mechanism of cellular protection, declines with aging. This study examined whether this also occurs humans. We measured the basal and inducible levels genes human bronchial epithelial (HBE) cells subjects young adult (21–29 years) older (60–69 non-smokers, explored factors affecting expresion. The expression three representative genes, catalytic modulator subunits...
All-CMOS monolithic microdisplay technologies have been attracting attention due to their direct integration of light-emitting pixel arrays and driving circuits on a single silicon substrate. Improvements optical power efficiency hot spot for all-silicon technologies. MOS-like gate-control structure avalanche-mode diodes (AMLEDs) that employ hot-carrier electroluminescence produce light emission are used enhance the units. A semi-active matrix mode is reduce consumption driver circuits....
Air pollution (AirP) is associated with many neurodevelopmental and neurological disorders in human populations. Rodent models show similar neurotoxic effects of AirP particulate matter (PM) collected by different methods or from various sources. However, controversies continue on the identity specific components mechanisms neurotoxicity. We urban PM two modes at same site time: direct collection as an aqueous slurry (sPM) versus a nano-sized sub-fraction PM0.2 that was eluted filters (nPM)....
Dietary use of curcumin, the active component tumeric, one most widely used spices, is linked to several beneficial health effects, although underlying molecular mechanisms remain largely unknown. Correlations have been established between curcumin exposure and increases in enzymes for glutathione synthesis, particularly glutamate-cysteine ligase (GCL), metabolism as well content, suggesting eliciting an adaptive response stress. In this study, using HBE1 cells, we found that mechanism...
Heme oxygenase-1 (HO-1) catalyzes the rate limiting reaction of heme metabolism and plays critical roles in resistance to oxidative stress other cellular functions. It is well known that HO-1 induced response various stresses; however, signaling pathways involved remain incompletely elucidated. Acrolein an alpha,beta-unsaturated aldehyde present cigarette smoke also a product lipid peroxidation. In this investigation we studied induction acrolein determined human bronchial epithelial cells...
Air pollution particulate matter exposure and chronic cerebral hypoperfusion (CCH) contribute to white toxicity through shared mechanisms of neuroinflammation, oxidative stress, myelin breakdown. Prior studies showed that mice joint CCH caused supra-additive injury corpus callosum matter. This study examines the role TLR4 (toll-like receptor 4) signaling in mediating neurotoxicity damage observed exposures.
4-Hydroxynonenal (HNE), a major electrophilic product of lipid peroxidation, is regarded as both marker oxidative stress and mediator damage. At subtoxic concentrations, however, this compound has been shown to be signalling molecule that can induce the expression various antioxidant/detoxification enzymes, including glutamate-cysteine ligase (GCL), rate-limiting enzyme in de novo synthesis glutathione. GCL consists catalytic (GCLC) modulatory (GCLM) subunit, which are encoded by separate...